Implementation of experimental test beds for Real Time diagnosis

Experimental test beds to study Real Time agents are common topic in AI. A principal contribution of this paper is to develop a framework for such experimental test beds. Design and implementation of the test bed and the extension of the framework for different equipment and agents are discussed. Results of an experiment with a simple digital circuit and heuristic agents to test the working of the test bed are reported

ANAESTHETIC MANAGEMENT OF A PATIENT WITH PREVIOUS LOBECTOMY POSTED FOR EMERGENCY MODIFIED RADICAL MASTOIDECTOMY

Pulmonary disease can be considered as a risk factor for several respiratory complications occurring during the perioperative period. Here we present a case of a middle-aged man who underwent modified radical mastoidectomy 23 y after left-sided lobectomy in order to illustrate the salient anesthetic considerations of this scenario.Keywords: Lobectomy, Mastoidectomy, Anaesthesia

Library Consortia Development Analysis with Special Reference to India

The study examines the library consortia research publications of the past two decades in order to gain insight into the development of library consortia, with a special emphasis on Indian contributions adopting Scientometrics analysis technique. Data was collected using the Web of Science abstracting and citation database, which retrieved 983 publications dating from 2001 to 2020. For the study, 326 relevant publications were selected and analysed using Biblioshny, Citespace and VOSviewer software. The analysis revealed a consistent research interest in library consortia, as shown by the increase in the number of publications and the number of keywords. India has secured 5th place in the production of publications, but the rate of contribution to the global publication was found to be significantly low (5%). Furthermore, neither Indian journals nor authors could reach the top ranking in library consortia publication. The United States dominated most of the extent of scientometric analysis. Recently, research focus was found around e,books, usage statistics, affordability and effective services. Research in the areas of cost benefit analysis, consortia framework and models are recommended to pay attention to significant output in library consortia research. On the whole, a big gap was observed in library consortia research. The outcomes of the research will aid in getting reliable and up-to-date information regarding library consortia research and offer insight into research trends

A Dynamic Ion-Atom Hybrid Trap for High-Resolution Cold-Collision Studies

We present a dynamic ion-atom hybrid trap for studies of cold ion-neutral collisions and reactions with a significantly improved energy resolution compared with previous experiments. Our approach is based on pushing a cloud of laser-cooled Rb atoms through a stationary Coulomb crystal of cold ions by using precisely controlled, tunable radiation pressure forces. We demonstrate the tuning of the atom kinetic energies over an interval ranging from 30 mK up to 350 mK with energy spreads as low as 24 mK, inferred from the comparison of experimental time-of-flight measurements with Monte Carlo trajectory simulations. We also demonstrate the first applications of our method to the investigation of chemical reactions. Our development opens up perspectives for accurate studies of the energy dependence of the reaction rates, the dynamics, and the reaction-product ratios of the ion-neutral processes in the cold regime. It also paves the way for the realization of fully energy- and state-controlled cold-collision experiments

Analytical study of modified Manashiladi Lepa into Ointment

Lepa Kalpana is one amongst the external application used in Ayurveda. Manashiladi Lepa is a formulation explained in ‘Rasa Tantra Sara Va Siddha Prayoga Sangraha’ for the prevention of scar in the skin surface. The formulation contains Ghrita and Madhu which is to be mixed with the powder of the herbs told in the formulation. In the present scenario, the Lepa Kalpana is not liked by the patients themselves as it leaves behind residual marks on the skin surface and stains the cloth if it comes in contact with it. Hence a modified Lepa in the form of ointment which contains reduced amount of oiliness and good packing is accepted by all. Literary review done through various sources like books, journals and internet revealed that, no modification studies have been carried out on this formulation yet. The Lepa is modified into an ointment for its easy acceptability and usage. The formulation is tested for its analytical values and discussed in the article

Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide

Previously, we showed that live Salmonella-containing phagosomes (LSP) recruit early acting Rab5 and promote fusion with early endosomes, thus avoiding transport to the lysosomes. Therefore, live Salmonella survive in a specialized compartment. Here we show that scavenger-receptor-mediated intracellular delivery of muramyl dipeptide (MDP) to macrophages leads to efficient killing of Salmonella both in vitro and in vivo. To understand the intracellular trafficking modulation of Salmonella by delivery of MDP, we investigated the levels of endocytic Rab proteins, which are the major regulators of vesicular transport. Western blot analysis reveals reduced Rab5 and enhanced Rab7 content in the maleylated bovine serum albumin-MDP (MBSA-MDP)-treated cells. The reduced content of Rab5 in the treated cells and on phagosomes inhibits the fusion of Salmonella-containing phagosomes with early endosomes, and the enhanced Rab7 content in these cells facilitated targeting of LSP to lysosomes, which contain cathepsin D and vacuolar ATPase, for killing. In vitro reconstitution of lysosomal transport demonstrated that a reduced content of Rab5 and an enhanced level of Rab7 in MBSA-MDP-treated cells is primarily responsible for targeting Salmonella to lysosomes. Intracellular delivery of MDP thus offers a general strategy against macrophage-associated infections caused by intracellular pathogens that survive in the host cell by resisting transport to lysosomes

Understanding Subjectivity through the Lens of Motivational Context in Model-Generated Image Satisfaction

Image generation models are poised to become ubiquitous in a range of applications. These models are often fine-tuned and evaluated using human quality judgments that assume a universal standard, failing to consider the subjectivity of such tasks. To investigate how to quantify subjectivity, and the scale of its impact, we measure how assessments differ among human annotators across different use cases. Simulating the effects of ordinarily latent elements of annotators subjectivity, we contrive a set of motivations (t-shirt graphics, presentation visuals, and phone background images) to contextualize a set of crowdsourcing tasks. Our results show that human evaluations of images vary within individual contexts and across combinations of contexts. Three key factors affecting this subjectivity are image appearance, image alignment with text, and representation of objects mentioned in the text. Our study highlights the importance of taking individual users and contexts into account, both when building and evaluating generative model