Targeting of anionic membrane species by lanthanide(III) complexes: towards improved MRI contrast agents for apoptosis

No abstract available

3,3′-{Ethane-1,2-diylbis[carbonylbis(azanediyl)]}dipyridinium tetra­chloridoplatinate(II)

In the crystal structure of the title compound, (C14H18N6O2)·[PtCl4], the cation and square-planar anion are located on special positions (on a twofold axis and an inversion centre, respectively). In the crystal structure, N—H⋯Cl hydrogen bonds lead to a staircase-like motif. The central ethane backbone of the cation is disordered over two positions of equal occupancy

Fuzzy Logic and VLSI Testing

A new application of Fuzzy logic (FL), in the context of test vector generation in VLSI testing is presented. Fuzzification of the threshold value simulation (TVS) approach and setting up of mathematical concepts are carried out in terms of a hierarchy of membership functions. The test-vectors are found by optimising a suitable membership function. The Fuzzy model besides giving a different mathematical basis, also helps in defining new and better optimising functions, thus provind its utility. The concepts outlined in this paper, though demonstrated on toy model of a circuit consisting of only AND gates, can easily be extended to circuits with other logic gates

The wisdom of crowds and the repurposing of artesunate as an anticancer drug.

Artesunate, a semi-synthetic and water-soluble artemisinin-derivative used as an anti-malarial agent, has attracted the attention of cancer researchers due to a broad range of anti-cancer activity including anti-angiogenic, immunomodulatory and treatment-sensitisation effects. In addition to pre-clinical evidence in a range of cancers, a recently completed randomised blinded trial in colorectal cancer has provided a positive signal for further clinical investigation. Used perioperatively artesunate appears to reduce the rate of disease recurrence - and the Neo-Art trial, a larger Phase II RCT, is seeking to confirm this positive effect. However, artesunate is a generic medication, and as with other trials of repurposed drugs, the Neo-Art trial does not have commercial sponsorship. In an innovative move, the trial is seeking funds directly from members of the public via a crowd-funding strategy that may have resonance beyond this single trial

CFLCA: High Performance based Heart disease Prediction System using Fuzzy Learning with Neural Networks

Human Diseases are increasing rapidly in today’s generation mainly due to the life style of people like poor diet, lack of exercises, drugs and alcohol consumption etc. But the most spreading disease that is commonly around 80% of people death direct and indirectly heart disease basis. In future (approximately after 10 years) maximum number of people may expire cause of heart diseases. Due to these reasons, many of researchers providing enormous remedy, data analysis in various proposed technologies for diagnosing heart diseases with plenty of medical data which is related to heart disease. In field of Medicine regularly receives very wide range of medical data in the form of text, image, audio, video, signal pockets, etc. This database contains raw dataset which consist of inconsistent and redundant data. The health care system is no doubt very rich in aspect of storing data but at the same time very poor in fetching knowledge. Data mining (DM) methods can help in extracting a valuable knowledge by applying DM terminologies like clustering, regression, segmentation, classification etc. After the collection of data when the dataset becomes larger and more complex than data mining algorithms and clustering algorithms (D-Tree, Neural Networks, K-means, etc.) are used. To get accuracy and precision values improved with proposed method of Cognitive Fuzzy Learning based Clustering Algorithm (CFLCA) method. CFLCA methodology creates advanced meta indexing for n-dimensional unstructured data. The heart disease dataset used after data enrichment and feature engineering with UCI machine learning algorithm, attain high level accurate and prediction rate. Through this proposed CFLCA algorithm is having high accuracy, precision and recall values of data analysis for heart diseases detection

Clinical Evaluation of Oxidative Stress in Women with Breast Cancer

Breast cancers are potentially life-threatening malignancies in women. Development of cancer produces oxidative stress, which increases with disease progression. Hence, studies on antioxidants may be the most promising area of research for this clinical menace. We analysed serum Uric acid (UA) and Bilirubin (BR) in women with breast cancer. The changes in the levels of serum uric acid and bilirubin are measured in breast cancer patients to assess the oxidative stress. A significant increase in the levels of uric acid and an insignificant increase in the levels of bilirubin was observed in all the three categories of breast cancer patients compared to normal individuals. The results suggested that high ROS production supports the oxidative stress in breast cancer. So, the treatment with antioxidants in the initial stages of the disease may be useful as secondary therapy

SURGICAL MANAGEMENT OF FRACTURE BOTH BONES FOREARM WITH LOCKING COMPRESSION PLATE IN ADULT PATIENTS

Objective: The objective of this study was to assess the time taken for surgery, tourniquet time, and clinical outcome in diaphyseal fractures of both forearms managed with locking compression plate (LCP). Methods: Patients underwent open reduction and internal fixation with 3.5-mm LCP. Proximal radius was approached by dorsal Thompson incision and middle and distal radius by volar henry approach. A minimum of 6 cortices were engaged with screw fixation in each fragment. Ulna was approached directly over the subcutaneous border. Results: Of 20 patients, 70% were men; fracture was the most common in second and third decades of life. Road traffic accident (50%) and fall (40%) were the main causes. Fractures at mid-diaphysis (70%) and transverse/short oblique (72.5%) were the most common. Closed head injury, unilateral pubic bone fracture, olecranon fracture, fracture of both bones of leg, and ipsilateral fracture shaft humerus were the associated injuries. There was no intraoperative complication. Superficial infection (n=01) and transient posterior interosseous nerve injury, in the immediate postoperative period (n=01), were the reported complications. Average time for surgery was 77 min (60–90 min) and that for tourniquet was 54 min (40–60 min). All had complete union in <6 months; 80% had healing in <4 months. 20% healed in 4–6 months. Excellent and satisfactory results were seen in 85% and 15% patients, respectively. Conclusion: The 3.5-mm LCP, when applied properly, yields excellent outcome in fractures of forearm bones. The use of tourniquet, separate incisions for radius and ulna, and preservation of the natural curves of radius will reduce complications. Clinical outcome in terms of healing and union is excellent

Taxol-DNA interactions: fluorescence and CD studies of DNA groove binding properties of taxol

Taxol is perhaps the most successful drug used for the treatment of various cancers. Comprehensive literature accumulated on therapeutics of the drug has indicated numerous side effects. In this paper, by use of fluorescence spectroscopy, it is shown that taxol binds to DNA with an affinity constant (Ka) of 1.08×107 M-1. This binding is accompanied by a large 'red edge excitation shift' (REES) of fluorescence emission maximum in taxol-DNA complex. The results point to an interaction of taxol with its core eight-membered ring in the DNA groove and the three phenyl rings projecting away from the DNA. The drug encompasses about two base pairs of DNA upon binding to it. Systematic studies with taxol analogues confirms such a mode of binding. These interesting findings on hitherto unknown taxol-DNA interactions may have clinical implications in view of its large number of side effects and pharmacokinetics

Effect of biovita granules and liquid on growth and yield of cotton (Gossypium hirsutum L.)

A study was conducted on effect of biovita granules and liquid on growth and yield of cotton during Kharif 2014 and 2015 in deep black soil at ARS, Dhadesugr, University of Agricultural Sciences, Raichur, Karnataka. Pooled data revealed that, cotton yield and green biomass yield were significantly (p=0.05) higher in the treatment with the application of biovita granule at 12.5 kg per hectare at one month after sowing followed by first spray of biovita liquid at 500 ml per hectare at square formation followed by second spray of biovita liquid at 750 ml per hectare at flowering and followed by third spray of biovita liquid at 750 ml per hectare at boll formation (1450 kg/ha and 1463 g/plant, respectively) and which was on par with the application of biovita granule at 10.0 kg per hectare at one month after sowing followed by first spray of biovita liquid at 500 ml per hectare at square formation followed by second spray of biovita liquid at 750 ml per hectare at flowering and followed by third spray of biovita liquid at 750 ml per hectare at boll formation (1377 kg/ha and 1439 g/plant, respectively). Whereas, application of only recommend-ed dose of fertilizer recorded significantly less cotton and green biomass yield compared to other treatments. The average per cent of increase in yield in biovita applied treatments (T1 to T8) over the no application of biovita treat-ment (T9) was 7.13 %