Moral panics versus youth problem debates: three conceptual insights from the study of Japanese youth

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Stanford-Binet and WAIS IQ differences and their implications for adults with intellectual disability (aka mental retardation)

Els components de diferents equips de la Congregació fent un vermut de germanor, veiem entre altres a Joan González, Ricard Farré, Antoni Bofill, Francesc Almiñana, Joan Pérez, Lluís Tortajada i Dídac Ramos

Weight Loss and Alzheimers Disease in Down Syndrome.

BACKGROUND: Virtually all adults with Down syndrome (DS) develop Alzheimers disease (AD) pathology, but research gaps remain in understanding early signs of AD in DS. OBJECTIVE: The goal of the present study was to determine if unintentional weight loss is part of AD in DS. The specific aims were to: 1) examine relation between chronological age, weight, AD pathology, and AD-related cognitive decline were assessed in a large cohort of adults with DS, and 2) determine if baseline PET amyloid-β (Aβ) and tau PET status (-versus+) and/or decline in memory and mental status were associated with weight loss prior to AD progression. METHODS: Analyses included 261 adults with DS. PET data were acquired using [11C] PiB for Aβ and [18F] AV-1451 for tau. Body mass index (BMI) was calculated from weight and height. Direct measures assessed dementia and memory. Clinical AD status was determined using a case consensus process. Percent weight decline across 16-20 months was assessed in a subset of participants (n = 77). RESULTS: Polynomial regressions indicated an 0.23 kg/m2 decrease in BMI per year beginning at age 36.5 years, which occurs alongside the period during which Aβ and tau increase and memory and mental status decline. At a within-person level, elevated Aβ, decline in memory and mental status were associated with higher percent weight loss across 16-20 months. CONCLUSION: Unintentional weight loss occurs alongside Aβ deposition and prior to onset of AD dementia, and thus may be a useful sign of AD in DS

‘Undesirable relationships’ between Jewish women and Arab men: Representation and discourse in contemporary Israel

Demography has been broadly considered as a key aspect of the Israeli–Palestinian conflict. On the Jewish side, State intervention to encourage Jewish immigration and Jewish births is well known. Much less known are the efforts to discourage inter-faith relations. These ‘problematic relationships’ between Arab men and Jewish women from low socio-economic backgrounds have become a high priority item in public discussions over the last decade. In this article I will explore the main discursive practices used in this heated debate by those opposing these relationships. ‘Moral panic’ as a theoretical framework will help me analyse the ways in which Jewish women and Arab men who engage in such relations are presented. As I will show, attempts to criminalize and vilify Arab men meet with strong opposition. Presenting Jewish women as weak and passive victims seems as a more successful strategy, especially when done by professionals from the psych-professions

Timing of Alzheimers Disease by Intellectual Disability Level in Down Syndrome.

BACKGROUND: Trisomy 21 causes Down syndrome (DS) and is a recognized cause of early-onset Alzheimers disease (AD). OBJECTIVE: The current study sought to determine if premorbid intellectual disability level (ID) was associated with variability in age-trajectories of AD biomarkers and cognitive impairments. General linear mixed models compared the age-trajectory of the AD biomarkers PET Aβ and tau and cognitive decline across premorbid ID levels (mild, moderate, and severe/profound), in models controlling trisomy type, APOE status, biological sex, and site. METHODS: Analyses involved adults with DS from the Alzheimers Biomarkers Consortium-Down Syndrome. Participants completed measures of memory, mental status, and visuospatial ability. Premorbid ID level was based on IQ or mental age scores prior to dementia concerns. PET was acquired using [11C] PiB for Aβ, and [18F] AV-1451 for tau. RESULTS: Cognitive data was available for 361 participants with a mean age of 45.22 (SD = 9.92) and PET biomarker data was available for 154 participants. There was not a significant effect of premorbid ID level by age on cognitive outcomes. There was not a significant effect of premorbid ID by age on PET Aβ or on tau PET. There was not a significant difference in age at time of study visit of those with mild cognitive impairment-DS or dementia by premorbid ID level. CONCLUSION: Findings provide robust evidence of a similar time course in AD trajectory across premorbid ID levels, laying the groundwork for the inclusion of individuals with DS with a variety of IQ levels in clinical AD trials

The Phytoene synthase gene family of apple (Malus x domestica) and its role in controlling fruit carotenoid content

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