580 research outputs found
Potential of the TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor for the monitoring of terrestrial chlorophyll fluorescence
Global monitoring of sun-induced chlorophyll fluorescence (SIF) is improving our knowledge about the photosynthetic functioning of terrestrial ecosystems. The feasibility of SIF retrievals from spaceborne atmospheric spectrometers has been demonstrated by a number of studies in the last years. In this work, we investigate the potential of the upcoming TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor satellite mission for SIF retrieval. TROPOMI will sample the 675–775 nm spectral window with a spectral resolution of 0.5 nm and a pixel size of 7 km × 7 km. We use an extensive set of simulated TROPOMI data in order to assess the uncertainty of single SIF retrievals and subsequent spatio-temporal composites. Our results illustrate the enormous improvement in SIF monitoring achievable with TROPOMI with respect to comparable spectrometers currently in-flight, such as the Global Ozone Monitoring Experiment-2 (GOME-2) instrument. We find that TROPOMI can reduce global uncertainties in SIF mapping by more than a factor of 2 with respect to GOME-2, which comes together with an approximately 5-fold improvement in spatial sampling. Finally, we discuss the potential of TROPOMI to map other important vegetation parameters at a global scale with moderate spatial resolution and short revisit time. Those include leaf photosynthetic pigments and proxies for canopy structure, which will complement SIF retrievals for a self-contained description of vegetation condition and functioning
The effect of sensor resolution on the number of cloud-free observations from space
International audienceAir quality and surface emission inversions are likely to be focal points for future satellite missions on atmospheric composition. Most important for these applications is sensitivity to the atmospheric composition in the lowest few kilometers of the troposphere. Reduced sensitivity by clouds needs to be minimized. In this study we have quantified the increase in number of useful footprints, i.e. footprints which are sufficient cloud-free, as a function of sensor resolution (footprint area). High resolution (1 km×1 km) MODIS TERRA cloud mask observations are aggregated to lower resolutions. Statistics for different thresholds on cloudiness are applied. For each month in 2004 two days of MODIS data are analyzed. Globally the fraction of cloud-free observations drops from 16% at 100 km2 resolution to only 3% at 10 000 km2 if not a single MODIS observation within a footprint is allowed to be cloudy. If up to 5% or 20% of a footprint is allowed to be cloudy, the fraction of cloud-free observations is 9% or 17%, respectively, at 10 000 km2 resolution. The probability of finding cloud-free observations for different sensor resolutions is also quantified as a function of geolocation and season, showing examples over Europe and northern South America
Collagen proportionate area correlates with histological stage and predicts clinical events in primary sclerosing cholangitis
Background & Aims:
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease in need of accurate biomarkers for stratification and as surrogates for clinical endpoints in trials. Quantitative liver fibrosis assessment by collagen proportionate area (CPA) measurement has been demonstrated to correlate with clinical outcomes in chronic hepatitis C, alcohol-related and non-alcoholic fatty liver disease. We aimed to investigate the ability of CPA to quantify liver fibrosis and predict clinical events in PSC.
Methods:
Biopsies from 101 PSC patients from two European centres were retrospectively assessed by two expert pathologists in tandem, using grading (Ishak and Nakanuma) and staging (Ishak, Nakanuma, Ludwig) systems recently validated to predict clinical events in PSC. CPA was determined by image analysis of picro-Sirius red-stained sections following a standard protocol. We assessed the correlations between CPA, staging and grading and their associations with three outcomes: (1) time to PSC-related death, liver transplant or primary liver cancer; (2) liver transplant-free survival; (3) occurrence of cirrhosis-related clinical manifestations.
Results:
CPA correlated strongly with histological stage determined by each scoring system (P < .001) and was significantly associated with the three endpoints. Median time to endpoint-1, endpoint-2 and endpoint-3 was shorter in patients with higher CPA, on Kaplan-Meier analyses (P = .011, P = .034 and P = .001, respectively).
Conclusion:
Quantitative fibrosis assessment by CPA has utility in PSC. It correlates with established histological staging systems and predicts clinical events. CPA may be a useful tool for staging fibrosis and for risk stratification in PSC and should be evaluated further within prospective clinical trials
COMPTEL detection of pulsed gamma-ray emission from B1509-58 up to at least 10 MeV
We report on the first firm detection of pulsed gamma-ray emission from PSR
B1509-58 in the 0.75-30 MeV energy range in CGRO COMPTEL data collected over
more than 6 years. The modulation significance in the 0.75-30 MeV pulse-phase
distribution is 5.4 sigma and the lightcurve is similar to the lightcurves
found earlier between 0.7 and 700 keV: a single broad asymmetric pulse reaching
its maximum 0.38 +/- 0.03 in phase after the radio peak, compared to the offset
of 0.30 found in the CGRO BATSE soft gamma-ray data, and 0.27 +/- 0.01 for RXTE
(2-16 keV), compatible with ASCA (0.7-2.2 keV). Spectral analysis based on the
excess counts in the broad pulse of the lightcurve shows that extrapolation of
the OSSE power-law spectral fit with index -1.68 describes our data well up to
10 MeV. Above 10 MeV the spectrum breaks abruptly. The precise location of the
break/bend between 10 and 30 MeV depends on the interpretation of the structure
in the lightcurve measured by COMPTEL and EGRET above 10 MeV.Comment: 15 pages, 10 figures, accepted for publication in Astronomy and
Astrophysic
Inter-network regions of the Sun at millimetre wavelengths
The continuum intensity at wavelengths around 1 mm provides an excellent way
to probe the solar chromosphere. Future high-resolution millimetre arrays, such
as the Atacama Large Millimeter Array (ALMA), will thus produce valuable input
for the ongoing controversy on the thermal structure and the dynamics of this
layer. Synthetic brightness temperature maps are calculated on basis of
three-dimensional radiation (magneto-)hydrodynamic (MHD) simulations. While the
millimetre continuum at 0.3mm originates mainly from the upper photosphere, the
longer wavelengths considered here map the low and middle chromosphere. The
effective formation height increases generally with wavelength and also from
disk-centre towards the solar limb. The average intensity contribution
functions are usually rather broad and in some cases they are even
double-peaked as there are contributions from hot shock waves and cool
post-shock regions in the model chromosphere. Taking into account the
deviations from ionisation equilibrium for hydrogen gives a less strong
variation of the electron density and with it of the optical depth. The result
is a narrower formation height range. The average brightness temperature
increases with wavelength and towards the limb. The relative contrast depends
on wavelength in the same way as the average intensity but decreases towards
the limb. The dependence of the brightness temperature distribution on
wavelength and disk-position can be explained with the differences in formation
height and the variation of temperature fluctuations with height in the model
atmospheres.Comment: 15 pages, 10 figures, accepted for publication in A&A (15.05.07
Potential of the TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor for the monitoring of terrestrial chlorophyll fluorescence
Global monitoring of sun-induced chlorophyll fluorescence (SIF) is improving our knowledge about the photosynthetic functioning of terrestrial ecosystems. The feasibility of SIF retrievals from spaceborne atmospheric spectrometers has been demonstrated by a number of studies in the last years. In this work, we investigate the potential of the upcoming TROPOspheric Monitoring Instrument (TROPOMI) onboard the Sentinel-5 Precursor satellite mission for SIF retrieval. TROPOMI will sample the 675–775 nm spectral window with a spectral resolution of 0.5 nm and a pixel size of 7 km × 7 km. We use an extensive set of simulated TROPOMI data in order to assess the uncertainty of single SIF retrievals and subsequent spatio-temporal composites. Our results illustrate the enormous improvement in SIF monitoring achievable with TROPOMI with respect to comparable spectrometers currently in-flight, such as the Global Ozone Monitoring Experiment-2 (GOME-2) instrument. We find that TROPOMI can reduce global uncertainties in SIF mapping by more than a factor of 2 with respect to GOME-2, which comes together with an approximately 5-fold improvement in spatial sampling. Finally, we discuss the potential of TROPOMI to map other important vegetation parameters at a global scale with moderate spatial resolution and short revisit time. Those include leaf photosynthetic pigments and proxies for canopy structure, which will complement SIF retrievals for a self-contained description of vegetation condition and functioning
Islet cell cytoplasmic antibody reactivity in midgestational human fetal pancreas
The reactivity of islet cell cytoplasmic antibodies (ICA)-positive and ICA-negative sera of recent onset type 1 diabetic patients was studied in human fetal pancreata of 12-18 weeks' gestation and compared with the reactivity of these sera in adult human control pancreata. The aims of the study were: (1) to observe the presence of ICA staining in human fetal islet cells; (2) to compare endpoint titres (in Juvenile Diabetes Foundation units) of ICA-positive patient sera in fetal pancreata and adult human control pancreata. Ten ICA-positive sera and eight ICA-negative sera from newly diagnosed diabetic patients and four sera from healthy controls were tested on three human adult and eight human fetal pancreata. As in the adult control pancreata. ICA-positive sera reacted to insulin-, glucagon-, and somatostatin-positive cells of fetal pancreata of all gestational ages. This was observed both in single cells and in cells in islet-like cell clusters. Dilution of a reference serum gave similar results in both adult and fetal pancreata. In contrast, the ICA-positive patient sera yielded a striking heterogeneity in fetal as well as in adult pancreata. However, end-point titres between adult and fetal pancreata did not differ significantly (P>0.05). In conclusion, ICA-positive sera from recent onset diabetic patients show that the expression of molecules to which ICA react is present in all islet cells and starts before week 12 of gestation
Basic opto-electronics on silicon for sensor applications
A general platform for integrated opto-electronic sensor systems on silicon is proposed. The system is based on a hybridly integrated semiconductor laser, ZnO optical waveguides and monolithic photodiodes and electronic circuiry
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