284 research outputs found
A 0535+26: an X-ray/Optical Tour
We compiled X-ray and Optical observations of the accreting X-ray binary
system A 0535+262 since its discovery in 1975, that will allow us to shed light
on the unpredictable behavior of this binary system. We present the data in
terms of the Be-disk interaction with the neutron star companion. In addition,
we show recent results from the continuous monitoring of this source by the
Gamma-ray Burst Monitor(GBM), on board the Fermi observatory, since its launch
in 2008 June 11.Comment: 4 pages, 5 figures, Conference proceeding of "Astrophysics of Neutron
Stars 2010 - a conference in honor of M. Ali Alpar", 2-6 August 2010, Cesme,
Izmir, Turke
Multifrequency Observations of the Blazar 3C 279 in January 2006
We report first results of a multifrequency campaign from radio to hard X-ray
energies of the prominent gamma-ray blazar 3C 279, which was organised around
an INTEGRAL ToO observation in January 2006, and triggered on its optical
state. The variable blazar was observed at an intermediate optical state, and a
well-covered multifrequency spectrum from radio to hard X-ray energies could be
derived. The SED shows the typical two-hump shape, the signature of non-thermal
synchrotron and inverse-Compton (IC) emission from a relativistic jet. By the
significant exposure times of INTEGRAL and Chandra, the IC spectrum (0.3 - 100
keV) was most accurately measured, showing - for the first time - a possible
bending. A comparison of this 2006 SED to the one observed in 2003, also
centered on an INTEGRAL observation, during an optical low-state, reveals the
surprising fact that - despite a significant change at the high-energy
synchrotron emission (near-IR/optical/UV) - the rest of the SED remains
unchanged. In particular, the low-energy IC emission (X- and hard X-ray
energies) remains the same as in 2003, proving that the two emission components
do not vary simultaneously, and provides strong constraints on the modelling of
the overall emission of 3C 279.Comment: 4 pages, 6 figures; to be published in the Proc. of the 6th INTEGRAL
workshop "The Obscured Universe" (Moscow, July 2-8, 2006), eds. S. Grebenev,
R. Sunyaev, C. Winkler, ESA SP 622 (2006
EXPLAIN Fragile-X: an explorative, longitudinal study on the characterization, treatment pathways, and patient-related outcomes of Fragile X Syndrome
BACKGROUND: Fragile X syndrome (FXS), caused by a mutation of the FMR1 gene on the X chromosome, is the most common inherited form of intellectual disability and autism spectrum disorders. Comprehensive data are lacking, however, on the characteristics and management patients with FXS in Germany. METHODS/DESIGN: EXPLAIN is a prospective, observational, longitudinal registry with a non-probability sampling approach. It collects data on patient characteristics, therapeutic interventions, psychosocial parameters (including those of family members and caregivers), quality of life of caregiver and patient, caregiver burden, and health economic parameters, such as hospitalisation time. It is designed to include data from 300 patients in ambulatory care from about 50 centres that employ psychiatrists, paediatricians, neurologists, and other relevant specialists, in Germany. The study was initiated in March, 2013. Patients will be followed for at least two years. DISCUSSION: The registry is expected to provide much-needed data on the characteristics and management of patients with FXS in Germany. It will also allow comparisons with other countries, and will enable gap analyses based on current guidelines for management of these patients. TRIAL REGISTRATION: The ClinicalTrials.gov identifier is NCT01711606
Characterization, treatment patterns, and patient-related outcomes of patients with Fragile X syndrome in Germany: final results of the observational EXPLAIN-FXS study
BACKGROUND: As data on the phenotype, characteristics and management of patients with Fragile X Syndrome (FXS) are limited, we aimed to collect such data in Germany in experienced centres involved in the treatment of such patients. METHODS: EXPLAIN-FXS is a prospective observational (non-interventional) study (registry) performed between April 2013 and January 2016 at 18 sites in Germany. Requirements for patient participation included confirmed diagnosis of FXS by genetic testing (>200 CGG repeats) and written informed consent. Patients were followed for up to 2 years. RESULTS: Seventy-five patients (84.0 % males, mean age 16.7 +/- 14.5 years, ranging from 2 - 82 years) were analysed. The mean 6-item score, determined according to Giangreco (J Pediatr 129:611-614, 1996), was 6.9 +/- 2.5 points. At least one neurological finding each was noted in 53 patients (69.7 %). Specifically, ataxia was noted in 5 patients (6.6 %), lack of fine motor skills in 40 patients, (52.6 %), muscle tonus disorder in 4 patients (5.3 %), and other neurological disorders in 39 patients (51.3 %). Spasticity was not noted in any patient. Seizures were reported in 6 patients (8.1 %), anxiety disorders in 22 patients (30.1 %), depression in 7 patients (9.6 %), ADHD/ADD in 36 patients (49.3 %), impairment of social behavior in 39 patients (53.4 %), and other comorbidities in 23 patients (31.5 %). The mean Aberrant Behaviour Checklist Community Edition (ABC-C) score on behavioral symptoms, obtained in 71 patients at first documentation, was 48.4 +/- 27.8 (median 45.0, range 5-115). The mean visual analogue scale (VAS) score, obtained in 59 patients at first documentation, was 84.9 +/- 14.6 points (median 90; range 50 - 100). CONCLUSIONS: This report describes the largest cohort of patients with FXS in Europe. The reported observations indicate a substantial burden of disease for patients and their caregivers. Based on these observations, an early expert psychiatric diagnosis is recommended for suspected FXS patients. Further recommendations include multimodal and multi-professional management that is tailored to the individual patient's needs
The Ge(001) (2 × 1) reconstruction: asymmetric dimers and multilayer relaxation observed by grazing incidence X-ray diffraction
Grazing incidence X-ray diffraction has been used to analyze in detail the atomic structure of the (2 × 1) reconstruction of the Ge(001) surface involving far reaching subsurface relaxations. Two kinds of disorder models, a statistical and a dynamical were taken into account for the data analysis, both indicating substantial disorder along the surface normal. This can only be correlated to asymmetric dimers.
Considering a statistical disorder model assuming randomly oriented dimers the analysis of 13 symmetrically independent in-plane fractional order reflections and of four fractional order reciprocal lattice rods up to the maximum attainable momentum transfer qz = 3c* (c* = 1.77 × 10−1 Å−1) indicates the formation of asymmetric dimers characterized by R>D = 2.46(5) Å as compared to the bulk bonding length of R = 2.45 Å. The dimer height of Δ Z = 0.74(15) Å corresponds to a dimer buckling angle of 17(4)°. The data refinement using anisotropic thermal parameters leads to a bonding length of RD = 2.44(4) Å and to a large anisotropy of the root mean-square vibration amplitudes of the dimer atoms (u112) 1/2 = 0.25 Å, (u222)1/2 = 0.14 Å, (u332)1/2 = 0.50 Å). We have evidence for lateral and vertical disp tenth layer below the surface
A 0535+26 in the August/September 2005 outburst observed by RXTE and INTEGRAL
In this Letter we present results from INTEGRAL and RXTE observations of the
spectral and timing behavior of the High Mass X-ray Binary A 0535+26 during its
August/September 2005 normal (type I) outburst with an average flux
F(5-100keV)~400mCrab. The search for cyclotron resonance scattering features
(fundamental and harmonic) is one major focus of the paper. Our analysis is
based on data from INTEGRAL and RXTE Target of Opportunity Observations
performed during the outburst. The pulse period is determined. X-ray pulse
profiles in different energy ranges are analyzed. The broad band INTEGRAL and
RXTE pulse phase averaged X-ray spectra are studied. The evolution of the
fundamental cyclotron line at different luminosities is analyzed. The pulse
period P is measured to be 103.39315(5)s at MJD 53614.5137. Two absorption
features are detected in the phase averaged spectra at E_1~45keV and
E_2~100keV. These can be interpreted as the fundamental cyclotron resonance
scattering feature and its first harmonic and therefore the magnetic field can
be estimated to be B~4x10^12G.Comment: 4 pages, 5 figures, accepted for publication in A&A Letter
Peculiar outburst of A 0535+26 observed with INTEGRAL, RXTE and Suzaku
A normal outburst of the Be/X-ray binary system A0535+26 has taken place in
August 2009. It is the fourth in a series of normal outbursts that have occured
around the periastron passage of the source, but is unusual by starting at an
earlier orbital phase and by presenting a peculiar double-peaked light curve. A
first "flare" (lasting about 9 days from MJD 55043 on) reached a flux of 440
mCrab. The flux then decreased to less than 220 mCrab, and increased again
reaching 440 mCrab around the periastron at MJD 55057. Target of Opportunity
observations have been performed with INTEGRAL, RXTE and Suzaku. First results
of these observations are presented, with special emphasis on the cyclotron
lines present in the X-ray spectrum of the source, as well as in the pulse
period and energy dependent pulse profiles of the source.Comment: 6 pages, Accepted for publication on PoS, Proceedings of "The Extreme
sky: Sampling the Universe above 10 keV", held in Otranto (Italy) in October
200
Multifrequency Observations of the Gamma-Ray Blazar 3C 279 in Low-State during Integral AO-1
We report first results of a multifrequency campaign from radio to hard X-ray
energies of the prominent gamma-ray blazar 3C 279 during the first year of the
INTEGRAL mission. The variable blazar was found at a low activity level, but
was detected by all participating instruments. Subsequently a multifrequency
spectrum could be compiled. The individual measurements as well as the compiled
multifrequency spectrum are presented. In addition, this 2003 broadband
spectrum is compared to one measured in 1999 during a high activity period of
3C 279.Comment: 4 pages including 6 figures, to appear in: 'Proc. of the 5th INTEGRAL
Workshop', ESA SP-552, in pres
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