The cyclin D1 carboxyl regulatory domain controls the division and differentiation of hematopoietic cells

International audienceAbstractBackgroundThe family of D cyclins has a fundamental role in cell cycle progression, but its members (D1, D2, D3) are believed to have redundant functions. However, there is some evidence that contradicts the notion of mutual redundancy and therefore this concept is still a matter of debate.ResultsOur data show that the cyclin D1 is indispensable for normal hematopoiesis. Indeed, in the absence of D1, either in genetic deficient mice, or after acute ablation by RNA interference, cyclins D2 and D3 are also not expressed preventing hematopoietic cell division and differentiation at its earliest stage. This role does not depend on the cyclin box, but on the carboxyl regulatory domain of D1 coded by exons 4–5, since hematopoietic differentiation is also blocked by the conditional ablation of this region.ConclusionThese results demonstrate that not all functions of individual D cyclins are redundant and highlight a master role of cyclin D1 in hematopoiesis

Species richness in dry grassland patches of eastern Austria: A multi-taxon study on the role of local, landscape and habitat quality variables

AbstractAccording to island biogeography theory, the species richness of patches is determined by their size and spatial isolation, while in conservation practice, it is patch quality that determines protection and guides management. We analysed whether size, isolation or habitat quality are most important for the species richness in a set of 50 dry grassland fragments in agricultural landscapes of eastern Austria. We studied two plant taxa (vascular plants, bryophytes) and 11 invertebrate taxa (gastropods, spiders, springtails, grasshoppers, true bugs, leafhoppers and planthoppers, ground beetles, rove beetles, butterflies and burnets, ants and wild bees). The species richness of three categories was analysed: (1) dry grassland specialist species, (2) all grassland species and (3) all species. We used regression and hierarchical partitioning techniques to determine the relationship between species richness and environmental variables describing patch size and shape, patch quality, landscape configuration and landscape quality. The area-isolation paradigm was only applicable for dry grassland specialists, which comprised 12% of all species. Richness of all grassland species was determined mostly by landscape heterogeneity parameters. Total species richness was highly influenced by spillover from adjacent biotopes, and was significantly determined by the percentage of arable land bordering the patches. When analysing all taxa together, species richness of dry grassland specialists was significantly related to historical patch size but not to current patch size, indicating an extinction debt. At the landscape scale, the variable ‘short-grass area’ was a better predictor than the less specific variable ‘area of extensively used landscape elements’. ‘Distance to mainland’ was a good predictor for specialists of mobile animal taxa. Plant specialists showed a pronounced dependence on quality measures at the patch scale and at the landscape scale, whereas animal specialists were influenced by patch size, patch quality, landscape quality and isolation measures. None of the taxa benefited from linear structures in the surroundings. In conclusion, high patch quality and a network of high-quality areas in the surrounding landscape should be the best conservation strategy to ensure conservation of dry grassland specialists. This goal does not conflict with the specific demands of single taxa

Systemic Risk Monitor: A Model for Systemic Risk Analysis and Stress Testing of Banking Systems

In 2002 the Oesterreichische Nationalbank (OeNB) launched in parallel several projects to develop modern tools for systemic financial stability analysis, off-site banking supervision and supervisory data analysis. In these projects the OeNB’s expertise in financial analysis and research was combined with expertise from the Austrian Financial Market Authority (FMA) and from academia. Systemic Risk Monitor (SRM) is part of this effort. SRM is a model to analyze banking supervision data and data from the Major Loans Register collected at the OeNB in an integrated quantitative risk management framework to assess systemic risk in the Austrian banking system at a quarterly frequency. SRM is also used to perform regular stress testing exercises. This paper gives an overview of the general ideas used by SRM and shows some of its applications to a recent Austrian dataset.Stress Testing, Banks, Financial Stability

Stress Testing the Exposure of Austrian Banks in Central and Eastern Europe

Austrian banks are heavily engaged in Central and Eastern European (CEE) markets primarily by running local subsidiaries but also by extending cross-border loans. We give an account of the historical development and the status quo of these exposures and conduct a stress test for the Austrian banking system with respect to its credit exposure vis-à-vis the CEE region. Our test is based on an analysis of the current state of the local banking systems from a risk perspective, inter alia drawing on stress testing experiences gained by the national central banks and the International Monetary Fund. We use a stress scenario that (i) takes account of the differences in host country risks and (ii) represents a worst case that deliberately exceeds historical shocks. It turns out that, despite the dramatic worsening of the economic environment implied by the scenario, the Austrian banking system is not put at risk by the hypothesized crisis. The possible repercussions of a crisis in a single country via solvency problems of the Austrian parent institution turn out to be well limited.financial stability, Central and Eastern Europe, stress t testing, credit risk.