Health Systems Global, the new international society for health systems research

I see starting a new international society for health systems research as a step towards renewing our collective commitment to global health goals; in particular I see the proposed society as marking a commitment to equitable universal health care. From my perspective it is important that we are clear on the values that underpin the development of this new society. In addition, the society needs a clear strategy to help achieve this goal, in particular we need to first identify who is the target audience or constituency for the society; and second, the tools through which the society will work and how the society will engage with its audience.Fil: Kraushaar, D.. No especifíca;Fil: Kieny, M. P.. Organizacion Mundial de la Salud; ArgentinaFil: Lazarus, J. V.. Health Systems Global; Estados UnidosFil: Bermejo, R.. University Of The Philippines; FilipinasFil: Abimbola, S.. National Primary Health Care Development Agency; NigeriaFil: Prashanth, N.. Institute Of Public Health; IndiaFil: Flores, W.. Center For The Study Of Equity And Governance In Health; GuatemalaFil: Freddie Ssengooba. Makerere University School Of Public Health; UgandaFil: Maceira, Daniel Alejandro. Centro de Estudios de Estado y Sociedad; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Serotonin 5-HT4 receptors in the nucleus accumbens are specifically involved in the appetite suppressant and not locomotor stimulant effects of MDMA ('ecstasy')

Abstract Rationale 3,4-Methylenedioxymethamphetamine (MDMA) abuse is a substantial problem in young adults. Due to a high focus on body image in this population, two main factors that may encourage MDMA use are the appetite suppressant and locomotor stimulant effects of this drug. The nucleus accumbens (NAc) is a brain region associated with the regulation of motivated and locomotor behaviours, and recent evidence suggests that NAc 5-HT4 receptors are likely to be involved in the appetite suppressant effect of MDMA. It has not yet been shown whether 5-HT4 receptors of the NAc are involved in the locomotor stimulant effects of MDMA, which may also contribute to a reduction in food intake. Objectives This study aimed to investigate the effect of local antagonism of serotonin 5-HT4 receptors in the NAc in the appetite suppressant and locomotor stimulant effects of MDMA. Methods Male hooded Wistar rats underwent surgery for the implantation of bilateral NAc microinjection cannulae under isofluorane anesthesia. Following 5-7 days of recovery, the rats received bilateral microinjections of the 5-HT4 antagonist RS39604 into the NAc immediately prior to either saline or MDMA administration. Food intake, water intake, body weight and locomotor activity were measured. Results RS39604 significantly increased food intake and increased weight loss in MDMA-treated but not saline-treated rats. Measures of MDMA-induced water intake or locomotor activity were not altered by antagonist administration. Conclusions These results demonstrate that 5-HT4 receptors in the NAc specifically regulate the appetite suppressant effects of MDMA but not MDMA-induced water intake or locomotor activity

Volcanic Initiation of the Eocene Heart Mountain Slide, Wyoming, USA

The Eocene Heart Mountain slide of northwest Wyoming covers an area of as much as 5000 km2 and includes allochthonous Paleozoic carbonate and Eocene volcanic rocks with a run-out distance of as much as 85 km. Recent geochronologic data indicated that the emplacement of the slide event occurred at ∼48.9 Ma, using laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) extracted from U-Pb zircon ages from basal layer and injectite carbonate ultracataclasite (CUC). We now refine that age with U-Pb results from a lamprophyre diatreme that is temporally and spatially related to the CUC injectites. The ages for the lamprophyre zircons are 48.97 ± 0.36 Ma (LA-ICPMS) and 49.19 ±0.02 Ma (chemical abrasion isotope dilution thermal ionization mass spectrometry). Thus, the lamprophyre and CUC zircons are identical in age, and we interpret that the zircons in the CUC were derived from the lamprophyre during slide emplacement. Moreover, the intrusion of the lamprophyre diatreme provided the trigger mechanism for the Heart Mountain slide. Additional structural data are presented for a variety of calcite twinning strains, results from anisotropy of magnetic susceptibility for the lamprophyre and CUC injectites and alternating-field demagnetization on the lamprophyre, to help constrain slide dynamics. These data indicate that White Mountain experienced a rotation about a vertical axis and minimum of 35° of counterclockwise motion during emplacement

Head of State of Exception

During the escalation of the “German Autumn” in 1977 the Federal German government resorted to a specific form of crisis management that had been described as an undeclared state of exception. It was Federal chancellor Helmut Schmidt in the first place who oversaw the anti-terrorist measures in the situation room where the executive branch ruled for six weeks beyond any parliamentary control. This article examines the role that Helmut Schmidt had played for the creation of a “subjective state of exception” (Julius Hatschek) and how this could be seen as stemming from Schmidt’s earlier experiences and handling of crisis situations dating back to the 1960s. In this regard it has to be asked with Giorgio Agamben, if in the West German case, the state of exception had become the rule

The 4He(p,d)3He reaction at 200 and 400 MeV

The distorted wave calculations are compared with the He-4(p,d) cross section. At all four energies the theoretical description of the data is relatively poor. While the general magnitude of the cross sections is not in bad agreement, the detailed slopes of the theoretical angular distributions miss the shapes of the experimental data in a rather fundamental way

LiST as a catalyst in program planning: experiences from Burkina Faso, Ghana and Malawi

Background African countries are working to achieve rapid reductions in maternal and child mortality and meet their targets for the Millennium Development Goals (MDGs). Partners in the Catalytic Initiative to Save One Million Lives (CI) are assisting them by providing funding and technical assistance to increase and accelerate coverage for proven interventions. Here we describe how the Lives Saved Tool (LiST) was used as part of an early assessment of the expected impact of CI plans in Malawi, Burkina Faso and Ghana

Gamma-Ray Telescopes (in "400 Years of Astronomical Telescopes")

The last half-century has seen dramatic developments in gamma-ray telescopes, from their initial conception and development through to their blossoming into full maturity as a potent research tool in astronomy. Gamma-ray telescopes are leading research in diverse areas such as gamma-ray bursts, blazars, Galactic transients, and the Galactic distribution of aluminum-26.Comment: 11 pages, 6 figures/ in "400 Years of Astronomical Telescopes: A Review of History, Science and Technology", ed. B.R. Brandl, R. Stuik, & J.K. Katgert-Merkeli (Exp. Astron. 26, 111-122 [2009]

Energy Dependence of the NN t-matrix in the Optical Potential for Elastic Nucleon-Nucleus Scattering

The influence of the energy dependence of the free NN t-matrix on the optical potential of nucleon-nucleus elastic scattering is investigated within the context of a full-folding model based on the impulse approximation. The treatment of the pole structure of the NN t-matrix, which has to be taken into account when integrating to negative energies is described in detail. We calculate proton-nucleus elastic scattering observables for $^{16}$O, $^{40}$Ca, and $^{208}$Pb between 65 and 200 MeV laboratory energy and study the effect of the energy dependence of the NN t-matrix. We compare this result with experiment and with calculations where the center-of-mass energy of the NN t-matrix is fixed at half the projectile energy. It is found that around 200 MeV the fixed energy approximation is a very good representation of the full calculation, however deviations occur when going to lower energies (65 MeV).Comment: 11 pages (revtex), 6 postscript figure