On the nature of the Herbig B[e] star binary system V921 Scorpii: Geometry and kinematics of the circumprimary disk on sub-AU scales

V921 Scorpii is a close binary system (separation 0.025") showing the B[e]-phenomenon. The system is surrounded by an enigmatic bipolar nebula, which might have been shaped by episodic mass-loss events, possibly triggered by dynamical interactions between the companion and the circumprimary disk (Kraus et al. 2012a). In this paper, we investigate the spatial structure and kinematics of the circumprimary disk, with the aim to obtain new insights into the still strongly debated evolutionary stage. For this purpose, we combine, for the first time, infrared spectro-interferometry (VLTI/AMBER, R=12,000) and spectro-astrometry (VLT/CRIRES, R=100,000), which allows us to study the AU-scale distribution of circumstellar gas and dust with an unprecedented velocity resolution of 3 km*s^-1. Using a model-independent photocenter analysis technique, we find that the Br-gamma-line emission rotates in the same plane as the dust disk. We can reproduce the wavelength-differential visibilities and phases and the double-peaked line profile using a Keplerian-rotating disk model. The derived mass of the central star is 5.4+/-0.4 M_sun*(d/1150 pc), which is considerably lower than expected from the spectral classification, suggesting that V921 Sco might be more distant (d approx 2kpc) than commonly assumed. Using the geometric information provided by our Br-gamma spectro-interferometric data and Paschen, Brackett, and Pfund line decrement measurements in 61 hydrogen recombination line transitions, we derive the density of the line-emitting gas (N_e=2...6*10^19 m^-3). Given that our measurements can be reproduced with a Keplerian velocity field without outflowing velocity component and the non-detection of age-indicating spectroscopic diagnostics, our study provides new evidence for the pre-main-sequence nature of V921 Sco.Comment: 17 pages, 11 figures, 3 tables, accepted by Ap

Exactly solvable charged dilaton gravity theories in two dimensions

We find exactly solvable dilaton gravity theories containing a U(1) gauge field in two dimensional space-time. The classical general solutions for the gravity sector (the metric plus the dilaton field) of the theories coupled to a massless complex scalar field are obtained in terms of the stress-energy tensor and the U(1) current of the scalar field. We discuss issues that arise when we attempt to use these models for the study of the gravitational back-reaction.Comment: The introductory part is changed. a version to appear in Class. Quant. Grav. 6 pages, RevTe

Nitric Oxide in the Control of the in vitro Proliferation and Differentiation of Human Hematopoietic Stem and Progenitor Cells

Hematopoietic stem and progenitor cell (HSPC) transplantation is the best-studied cellular therapy and successful in vitro control of HSPCs has wide clinical implications. Nitric oxide (NO) is a central signaling molecule in vivo and has been implicated in HSPC mobilization to the blood stream in mice. The influence of NO on HSPC behavior in vitro is, however, largely obscure due to the variety of employed cell types, NO administration systems, and used concentration ranges in the literature. Additionally, most studies are based on murine cells, which do not necessarily mimic human HSPC behavior. Thus, the aim of the present study was the systematic, concentration-dependent evaluation of NO-mediated effects on human HSPC behavior in vitro. By culture in the presence of the long-term NO donor diethylenetriamine/nitric oxide adduct (DETA/NO) in a nontoxic concentration window, a biphasic role of NO in the regulation of HSPC behavior was identified: Low DETA/NO concentrations activated classical NO signaling, identified via increased intracellular cyclic guanosine monophosphate (cGMP) levels and proteinkinases G (PKG)-dependent vasodilator-stimulated phosphoprotein (VASP) phosphorylation and mediated a pro-proliferative response of HSPCs. In contrast, elevated NO concentrations slowed cell proliferation and induced HSPC differentiation. At high concentrations, s-nitrosylation levels were elevated, and myeloid differentiation was increased at the expense of lymphoid progenitors. Together, these findings hint at a central role of NO in regulating human HSPC behavior and stress the importance and the potential of the use of adequate NO concentrations for in vitro cultures of HSPCs, with possible implications for clinical application of in vitro expanded or differentiated HSPCs for cellular therapies

Quantum Games with Correlated Noise

We analyze quantum game with correlated noise through generalized quantization scheme. Four different combinations on the basis of entanglement of initial quantum state and the measurement basis are analyzed. It is shown that the advantage that a quantum player can get by exploiting quantum strategies is only valid when both the initial quantum state and the measurement basis are in entangled form. Furthermore, it is shown that for maximum correlation the effects of decoherence diminish and it behaves as a noiseless game.Comment: 12 page

Operational quasiprobabilities for qudits

We propose an operational quasiprobability function for qudits, enabling a comparison between quantum and hidden-variable theories. We show that the quasiprobability function becomes positive semidefinite if consecutive measurement results are described by a hidden-variable model with locality and noninvasive measurability assumed. Otherwise, it is negative valued. The negativity depends on the observables to be measured as well as a given state, as the quasiprobability function is operationally defined. We also propose a marginal quasiprobability function and show that it plays the role of an entanglement witness for two qudits. In addition, we discuss an optical experiment of a polarization qubit to demonstrate its nonclassicality in terms of the quasiprobability function.Comment: 10 pages, 4 figures, journal versio

Entanglement capability of self-inverse Hamiltonian evolution

We determine the entanglement capability of self-inverse Hamiltonian evolution, which reduces to the known result for Ising Hamiltonian, and identify optimal input states for yielding the maximal entanglement rate. We introduce the concept of the operator entanglement rate, and find that the maximal operator entanglement rate gives a lower bound on the entanglement capability of a general Hamiltonian.Comment: 4 pages, no figures. Version 3: small change

3D models of the hematopoietic stem cell niche under steady-state and active conditions

Hematopoietic stem cells (HSCs) in the bone marrow are able to differentiate into all types of blood cells and supply the organism each day with billions of fresh cells. They are applied to cure hematological diseases such as leukemia. The clinical need for HSCs is high and there is a demand for being able to control and multiply HSCs in vitro. The hematopoietic system is highly proliferative and thus sensitive to anti-proliferative drugs such as chemotherapeutics. For many of these drugs suppression of the hematopoietic system is the dose-limiting toxicity. Therefore, biomimetic 3D models of the HSC niche that allow to control HSC behavior in vitro and to test drugs in a human setting are relevant for the clinics and pharmacology. Here, we describe a perfused 3D bone marrow analog that allows mimicking the HSC niche under steady-state and activated conditions that favor either HSC maintenance or differentiation, respectively, and allows for drug testing