Fracture Detection using Amplitude versus Offset and Azimuth Analysis of a 3D P-wave Seismic Dataset and Synthetic Examples

Amplitude versus offset (AVO) analysis of seismic reflection data has been a successful tool in describing changes in rock properties along a reflector. This method is extended to azimuthal AVO (AVOA) in order to characterize vertically aligned fractures within a reservoir, which can be important fluid migration pathways. AVOA analysis is performed on synthetic data using a least squares inversion method to investigate the effects of varying acquisition geometry, amount of noise, and fracture properties. These tests show that it is possible to detect the fractured layer and determine the fracture strike orientation under typical acquisition conditions. This method is also applied to field data collected during an Ocean Bottom Cable (OBC) survey. These data include a broad offset-azimuth range, which is important for the AVOA analysis. The fracture location and strike orientation recovered from the field data analysis are well correlated with borehole information from this area. Based on an understanding of AVOA behavior under synthetic conditions, this technique provides an effective methodology for describing the spatial variability of a fractured reservoir using 3D seismic data.Eni S.p.A. (Firm)United States. Dept. of Energy (Grant number DE-FC26-02NT15346)Massachusetts Institute of Technology. Earth Resources Laborator

Crustal and uppermost mantle structure of Caucasus and surrounding regions

A 3-D P-wave velocity model is developed for the crust and uppermost mantle of Caucasus and the surrounding area by applying the tomographic method of Zhao et al. using 300 000 high-quality P-wave first arrivals from 43 000 events between 1964 and 2005. This tomographic method can accommodate velocity discontinuities such as the Moho in addition to smooth velocity variations. The spatial resolution is 1°×1° in the horizontal direction and 10 km in depth. The velocity images of the upper crust correspond well with the surface geology. Beneath the southern Caucasus high velocity anomalies are found in the middle crust and low velocity anomalies are found in the uppermost mantle. Relatively low Pn velocities are located under the Lesser Caucasus, eastern Turkey, and northern Iran. Higher Pn velocities occur under the eastern portion of the Black Sea and the southern Caspian Sea, and also extend into the eastern edge of Azerbaijan. Tomographic model significantly reduces the travel-time residuals.United States. Defense Threat Reduction Agency (Contracts DE-AC-52-04NA25612, NNSA-03-2S2 and W-7405-ENG-483)Chinese Academy of Sciences (Fund KJCX2-EW-121

The effectiveness of emergency obstetric referral interventions in developing country settings : a systematic review

Peer reviewedPublisher PD

A Deep Learning based Pipeline for Efficient Oral Cancer Screening on Whole Slide Images

Oral cancer incidence is rapidly increasing worldwide. The most important determinant factor in cancer survival is early diagnosis. To facilitate large scale screening, we propose a fully automated pipeline for oral cancer detection on whole slide cytology images. The pipeline consists of fully convolutional regression-based nucleus detection, followed by per-cell focus selection, and CNN based classification. Our novel focus selection step provides fast per-cell focus decisions at human-level accuracy. We demonstrate that the pipeline provides efficient cancer classification of whole slide cytology images, improving over previous results both in terms of accuracy and feasibility. The complete source code is available at https://github.com/MIDA-group/OralScreen.Comment: Accepted to ICIAR 202

Features of the opportunistic behaviour of the marine bacterium marinobacter algicola in the microalga ostreococcus tauri phycosphere

Although interactions between microalgae and bacteria are observed in both natural environment and the laboratory, the modalities of coexistence of bacteria inside microalgae phycospheres in laboratory cultures are mostly unknown. Here, we focused on well-controlled cultures of the model green picoalga Ostreococcus tauri and the most abundant member of its phycosphere, Marinobacter algicola. The prevalence of M. algicola in O. tauri cultures raises questions about how this bacterium maintains itself under laboratory conditions in the microalga culture. The results showed that M. algicola did not promote O. tauri growth in the absence of vitamin B12 while M. algicola depended on O. tauri to grow in synthetic medium, most likely to obtain organic carbon sources provided by the microalgae. M. algicola grew on a range of lipids, including triacylglycerols that are known to be produced by O. tauri in culture during abiotic stress. Genomic screening revealed the absence of genes of two particular modes of quorum-sensing in Marinobacter genomes which refutes the idea that these bacterial communication systems operate in this genus. To date, the ‘opportunistic’ behaviour of M. algicola in the laboratory is limited to several phytoplanktonic species including Chlorophyta such as O. tauri. This would indicate a preferential occurrence of M. algicola in association with these specific microalgae under optimum laboratory conditions

Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors

Contains fulltext : 88032.pdf (publisher's version ) (Closed access)INTRODUCTION: In cancer, an extracellular and membrane bound localization of cathepsins contribute to the invasion of tumor cells at the basement membrane. METHODS: This is the first study that explored levels of cathepsins B (CatB), L (CatL) and their inhibitor cystatin C (CysC) in the cystic fluid (CF) of ovarian tumors (n = 110). RESULTS: CF contained considerable amounts of CatB, CatL and CysC. Remarkable differences in CatB and CatL and CysC CF levels were found between different histopathological tumor subtypes. Levels of CatB and CysC were significantly higher in CF of malignant serous tumors compared to those found in benign serous tumors (p = 0.010 and p = 0.001 respectively), whereas levels of CatL were significantly higher in CF of malignant mucinous tumors compared to those found in benign mucinous tumors (p = 0.035). CatB and CysC showed a strong correlation in the group of patients with malignant serous tumors (p < 0.001; R = 0.921) suggesting that the increase in CatB might be balanced by a corresponding increase in CysC. CONCLUSION: Further studies are warranted to investigate cathepsins as possible prognostic biomarkers for the aggressiveness of ovarian cancer.1 mei 201

Evolution of sex determination and heterogamety changes in section Otites of the genus Silene

Abstract Switches in heterogamety are known to occur in both animals and plants. Although plant sex determination systems probably often evolved more recently than those in several well-studied animals, including mammals, and have had less time for switches to occur, we previously detected a switch in heterogamety in the plant genus Silene: section Otites has both female and male heterogamety, whereas S. latifolia and its close relatives, in a different section of the genus, Melandrium (subgenus Behenantha), all have male heterogamety. Here we analyse the evolution of sex chromosomes in section Otites, which is estimated to have evolved only about 0.55 MYA. Our study confirms female heterogamety in S. otites and newly reveals female heterogamety in S. borysthenica. Sequence analyses and genetic mapping show that the sex-linked regions of these two species are the same, but the region in S. colpophylla, a close relative with male heterogamety, is different. The sex chromosome pairs of S. colpophylla and S. otites each correspond to an autosome of the other species, and both differ from the XY pair in S. latifolia. Silene section Otites species are suitable for detailed studies of the events involved in such changes, and our phylogenetic analysis suggests a possible change from female to male heterogamety within this section. Our analyses suggest a possibility that has so far not been considered, change in heterogamety through hybridization, in which a male-determining chromosome from one species is introgressed into another one, and over-rides its previous sex-determining system