ORGANIZATION NEPHROLOGIC ASSISTANCE IN KYIVCITY: PROBLEMS AND THEIR SOLUTIONS

The article are covering problems for the organization of nephrological care in Kyiv. Regulations according to which nephrological assistance is provided to city residents are listed. Proposals to improve the nephrological aid in Kншv are presente

INTERLEUKIN 10, BODY MASS INDEX AND SERUM ALBUMIN IN CHRONIC KIDNEY DISEASE STAGE 5D PATIENTS

IL-10 - one of the central factors in the altered cytokine network of uremia, may play important role in the development of T-helper imbalance, CVD and wasting in dialysis patients. Aim: to evaluate level of ІL-10 in CKD stage 5D patients depending on the body mass index and serum albumin. Methods: Thirty-nine HD patients were included (male/female 20/19, age 21- 53 years, mean dialysis treatment time 4.2 ± 1.21 years). Blood tests were taken before a midweek dialysis session. Serum IL-10, serum albumin and BMI were measured. Results: HD patients had higher serum IL-10 than healthy donors (79.9 ± 7.3 vs. 18.8 ± 1.3 pg/ml, p < 0.001). Patients with low BMI had lower serum IL-10 than patients with normal BMI and large BMI – 31.0 ± 6.3 pg/ml; 76.7 ± 10.1 pg/ml; 117.7 ± 6.2 pg/ml, respectively (p < 0.001). Higher IL-10 was associated with increased serum albumin. Conclusion: Compensative increase of anti-inflammatory cytokine IL-10 in serum is typical in HD patients. Patients with nutrition deficit are characterized by lower serum IL-10

LEVELS ANTIINFAMMATORY CYTOKINES (ІL-4, ІL-10) IN MAINTENCE HEMODIALYSIS PATIENTS DEPENDING ON EXPRESSED ANAEMIA AND CHARACTER DEFEAT OF KIDNEY

Aims: The purpose of the present study was to compare the levels of anti-inflammatory cytokines in patients with chronic kidney disease, prolonged sessions of hemodialysis, depending on the severity of anemia. Materials and methods: We investigated 155 patients with chronic kidney disease, prolonged sessions of hemodialysis and anemia (mean age 46.4±12.4). Patients were divided into 4 groups depending on expressed of anemia: in the I-st (n=22) group – patients with the level of hemoglobin over 110g/l, in the II (n=66) group hemoglobin 90 - 110g/l, in the III (n=44) group hemoglobin 70-89 g/l, in the IV (n=22) group hemoglobin <70 g/l. Results: We have defined that level of IL-4 was clinically significantly lower (p <0.001) in patients, who have getting hemodialysis by comparison to control group. Levels of IL-4 had a significant differences between all of group of patients and controls (p <0.05). IL-10 had a positive correlation with the level of Hb (r=0.2405; p=0.003). ІL-4 had a negative correlation with the level of Hb (r=-0.4842; p <0.001). The average level of IL-4 was significantly increased in diabetic patients compared with non-diabetic patients 92±17.7 vs 48.3±28.1 (p <0.05). Conclusions: All of studied patients have had an increased level of anti- inflammatory cytokines. Serum IL-4 was higher in patients with diabetes. The levels of anti-inflammatory cytokines (IL-4 and IL-10) have had a significant correlation with the severity of anemia

EFFICACY AND SAFETY OF IRON (III)–HYDROXIDE SUCROSE COMPLEX IN CORRECTION OF ANEMIA STAGE 5D CHRONIC KIDNEYDISEASE HEMODIALYSIS PATIENTS NOT TREATED BY ERYTHROPOIESIS–STIMULATING AGENTS (PROSPECTIVEANALYSIS)

The aim of study was to evaluat the efficacy and safety ofSUFER® (iron (III) sucrose complex) in correction of anemia stage 5D chronic kidney disease hemodialysis patients. Methods. This study included thirty patients undergoing regular hemodialysis (mean age 48,81±3,24 years, mean duration of dialysis 30,43±9,25 months) with renal anemia and iron deficiency. All patients were treated with SUFER® intravenously 200 mg three times a week. Correction dose was determined according to the manufacturer’s recommendations. Results. Mean level offerritin was significantly increased from 125,15 ± 21,46 ng / ml to 375,56 ± 64,12 ng / ml (p <0,001), transferrin saturation – from 17,48 ± 2,71% to 38,21 ± 4,90 ng / ml (p <0,001). 23 (76.67%) patients achieved target levels offerritin and transferrin, 12 (40% ) adverse events. Conclusions. SUFER® is effective and safety drug in dialysis patients

ON INFLUENCE OF PERICLASE BRIDGES WITH CALCIUM FILTERS IN POURING BOX ON ALLOCATION OF NONMETALLICS IN CORD ROLLED WIRE

Influence of technological bridges in pouring box on allocation of nonmetallics by size is investigated in industrial conditions

MODERNIZATION OF TRACKING SYSTEM OF SECOND LEVEL OF ROLLING MILL 850

Short description of rolling mill 850 is given

РОЗРОБКА КРЕАТИНІН-ЧУТЛИВОГО БІОСЕНСОРА ДЛЯ МЕДИЧНОГО ЗАСТОСУВАННЯ

A highly-sensitive biosensor based on immobilized creatininedeiminase (EC 3.5.4.21) and pH-sensitive field effect transistors was developed for creatinine detection in dialysis fluid. The conditions of the enzyme immobilization as well as conditions of creatinine detection in both model and real samples were optimized. Under optimized conditions, the enzyme biosensor is capable of express analysis of creatinine and characterized with high sensitivity, selectivity, and reproducibility.Разработан высокочувствительный селективный биосенсор на основе иммобилизированной креатининдеиминазы (КФ 3.5.4.21) и рН-чувствительных полевых транзисторов для on-line определения креатинина в диализной жидкости. Оптимизированы условия проведения анализа креатинина в модельных и реальных образцах. Полученный ферментный биосенсор характеризуется экспресностью анализа, высокой чувствительностью, селективностью и воспроизведением сигналов.Розроблено високочутливий селективний біосенсор на основі іммобілізованої креатиніндеімінази (КФ 3.5.4.21) та рН-чутливих польових транзисторів для on-line визначення креатиніну в діалізаті. Оптимізовано умови створення біоселективного елементу та підібрано оптимальні умови проведення аналізу креатиніну у модельних та реальних зразках. Отриманий ферментний біосенсор характеризується експресністю аналізу, високою чутливістю, селективністю та відтворюваністю сигналів

MATHEMATICAL MODELING OF NONMETALLIC PARTICLES MECHANICAL TRAJECTORY IN POURING BOX OF MNLZ

The mathematical model for calculations of nonmetallic impurities guidepath in system “steel ladle-pony ladle-crystallizer” is developed. Guidepathes of nonmetallic  particles of  different density, moving from steel ladle into crystallizer, are investigated on the sample of internal cavity of pony ladle of MNLZ RUP “BMZ”