71 research outputs found

    Perspektiven des Einstiegs: gemeinsame Erfahrungsräume von Menschen in Aktivierungsmaßnahmen der Sozialhilfe

    Full text link
    "Der Beitrag geht den gemeinsamen Erfahrungsräumen von Menschen in Aktivierungsmaßnahmen der Sozialhilfe nach, die mit Hilfe von Gruppendiskussionen gewonnen wurden. Aktivierungsmaßnahmen wollen Sozialhilfebezieher/innen in den Arbeitsmarkt integrieren und weisen aufgrund ihrer spezifischen Konstruktion den Betroffenen einen besonderen Status zu, der allzu oft nicht in einer Inklusion in die Gesellschaft mündet. Ein Vergleich der Diskussionen in Graz, Klagenfurt, Linz und Wien macht Differenzen aufgrund der städtespezifischen Struktur der Maßnahmen und der unterschiedlichen Lebenssituation der Teilnehmer/innen ersichtlich. Dennoch wird ebenso erkennbar, dass sich die Teilnehmer/innen in einer permanenten Einstiegssituation befinden, weil die Projekte nicht immer eine Arbeitsmarktintegration zum Ziel haben." (Autorenreferat)"This article explores common experiences of participants in activation projects of the social assistance that were collected in group discussions. Activation schemes display distinct forms of inclusion, establishing a specific status for the participants, however, too often without an inclusion in society. A comparison of discussions in Graz, Klagenfurt, Linz, and Vienna indicates certain differences due to local structures of the projects and concrete living conditions of the participants. Despite those structural reasons, it is also obvious that the participants are in a 'permanent entry situation', because not all projects have the goal of integration into the labor market." (author's abstract

    Una propuesta para afrontar obstáculos epistemológicos en el aprendizaje de la matemática

    Get PDF
    En este trabajo se resumirán algunos elementos teóricos que consideramos importantes en la Educación Matemática, como son: los obstáculos epistemológicos, la imagen conceptual y los sistemas y registros de representación semiótica. Luego se abordarán dos problemas de la Educación Matemática, analizando los conceptos antes propuestos y observando distintos resultados ofrecidos por algunas investigaciones realizadas. Ellos son: el problema “0,9=1” y el problema de “las funciones continuas”. Ambos problemas ofrecen ejemplos relativamente claros de la diversidad de obstáculos que entran en juego en las instancias de aprendizaje. Además de esto se presentarán algunas actividades, a modo de propuesta para la enseñanza, que consideramos que contribuirían a completar ciertos conceptos que podrían quedar incompletos

    Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1

    Get PDF
    Recent studies have shown that the targeting of substrate adhesions by microtubules promotes adhesion site disassembly (Kaverina, I., O. Krylyshkina, and J.V. Small. 1999. J. Cell Biol. 146:1033–1043). It was accordingly suggested that microtubules serve to convey a signal to adhesion sites to modulate their turnover. Because microtubule motors would be the most likely candidates for effecting signal transmission, we have investigated the consequence of blocking microtubule motor activity on adhesion site dynamics. Using a function-blocking antibody as well as dynamitin overexpression, we found that a block in dynein–cargo interaction induced no change in adhesion site dynamics in Xenopus fibroblasts. In comparison, a block of kinesin-1 activity, either via microinjection of the SUK-4 antibody or of a kinesin-1 heavy chain construct mutated in the motor domain, induced a dramatic increase in the size and reduction in number of substrate adhesions, mimicking the effect observed after microtubule disruption by nocodazole. Blockage of kinesin activity had no influence on either the ability of microtubules to target substrate adhesions or on microtubule polymerisation dynamics. We conclude that conventional kinesin is not required for the guidance of microtubules into substrate adhesions, but is required for the focal delivery of a component(s) that retards their growth or promotes their disassembly

    Characterization of a newly identified ETV6-NTRK3 fusion transcript in acute myeloid leukemia

    Get PDF
    BACKGROUND: Characterization of novel fusion genes in acute leukemia is important for gaining information about leukemia genesis. We describe the characterization of a new ETV6 fusion gene in acute myeloid leukemia (AML) FAB M0 as a result of an uncommon translocation involving chromosomes 12 and 15. METHODS: The ETV6 locus at 12p13 was shown to be translocated and to constitute the 5' end of the fusion product by ETV6 break apart fluorescence in situ hybridisation (FISH). To identify a fusion partner 3' rapid amplification of cDNA-ends with polymerase chain reaction (RACE PCR) was performed followed by cloning and sequencing. RESULTS: The NTRK3 gene on chromosome 15 was found to constitute the 3' end of the fusion gene and the underlying ETV6-NTRK3 rearrangement was verified by reverse transcriptase PCR. No RNA of the reciprocal NTRK3-ETV6 fusion gene could be detected. CONCLUSION: We have characterized a novel ETV6-NTRK3 fusion transcript which has not been previously described in AML FAB M0 by FISH and RACE PCR. ETV6-NTRK3 rearrangements have been described in secretory breast carcinoma and congenital fibrosarcoma

    Ad Orativncvlas Qvasdam De Proditionis Crimine Ipsis Qve Proditorvm Fatis : In Lyceo Vitembergensi Eivsqve Avditorio Maiori A. R. S. MDCCXIII. Prid. Id. April. H. III. Pomerid A Qvibvsdam Alvmnis Habendas Omnes Reip. Liter. Proceres Et Favtores Sigillatim Magnif. Dominvm Ephorvm Atqve Ampliss. Hvivs Civitatis Senatvm Svmma Animi Observantia Et Officiorvm Svorvm In Singvlos Testificatione

    No full text
    Invitat M. Chr. Frid. Kranevvittervs Fac. Phil. Ass. Et Lycei Opp. Rector.Wittenberg, Einl.-P. zu d. Redeübungen d. Gymn. am 12. Apr. 1713Autopsie nach Ex. der ULB Sachsen-AnhaltVorlageform des Erscheinungsvermerks: Vitembergæ Saxonvm Imprimebat Io. Lvdolphvs Fincelivs. - Erscheinungsjahr der Datierung im Titel entnomme

    Guideline zur Langzeitarchivierung

    Get PDF
    Guideline for Digital Preservation of data in an academic setting
    corecore