Simultaneous X-ray and Radio Observations of Rotating Radio Transient J1819-1458

We present the results of simultaneous radio and X-ray observations of PSR J1819-1458. Our 94-ks XMM-Newton observation of the high magnetic field 5*10^13 G pulsar reveals a blackbody spectrum (kT~130 eV) with a broad absorption feature, possibly composed of two lines at ~1.0 and ~1.3 keV. We performed a correlation analysis of the X-ray photons with radio pulses detected in 16.2 hours of simultaneous observations at 1-2 GHz with the Green Bank, Effelsberg, and Parkes telescopes, respectively. Both the detected X-ray photons and radio pulses appear to be randomly distributed in time. We find tentative evidence for a correlation between the detected radio pulses and X-ray photons on timescales of less than 10 pulsar spin periods, with the probability of this occurring by chance being 0.46%. This suggests that the physical process producing the radio pulses may also heat the polar-cap.Comment: 12 pages, 5 figures, Accepted to Ap

Natural variability is essential to learning new faces

We learn new faces throughout life, for example in everyday settings like watching TV. Recent research has shown that image variability is key to this ability: if we learn a new face over highly variable images, we are better able to recognize that person in novel pictures. Here we asked people to watch TV shows they had not seen before, and then tested their ability to recognize the actors. Some participants watched TV shows in the conventional manner, whereas others watched them upside down or contrast-reversed. Image variability is equivalent across these conditions, and yet we observed that viewers were unable to learn the faces upside down or contrast-reversed - even when tested in the same format as learning. We conclude that variability is a necessary, but not sufficient, condition for face learning. Instead, mechanisms underlying this process are tuned to extract useful information from variability falling within a critical range that corresponds to natural, everyday variation

Robust social categorization emerges from learning the identities of very few faces

Viewers are highly accurate at recognizing sex and race from faces-though it remains unclear how this is achieved. Recognition of familiar faces is also highly accurate across a very large range of viewing conditions, despite the difficulty of the problem. Here we show that computation of sex and race can emerge incidentally from a system designed to compute identity. We emphasize the role of multiple encounters with a small number of people, which we take to underlie human face learning. We use highly variable everyday 'ambient' images of a few people to train a Linear Discriminant Analysis (LDA) model on identity. The resulting model has human-like properties, including a facility to cohere previously unseen ambient images of familiar (trained) people-an ability which breaks down for the faces of unknown (untrained) people. The first dimension created by the identity-trained LDA classifies both familiar and unfamiliar faces by sex, and the second dimension classifies faces by race- even though neither of these categories was explicitly coded at learning. By varying the numbers and types of face identities on which a further series of LDA models were trained, we show that this incidental learning of sex and race reflects covariation between these social categories and face identity, and that a remarkably small number of identities need be learnt before such incidental dimensions emerge. The task of learning to recognize familiar faces is sufficient to create certain salient social categories

Precision timing of PSR J1012+5307 and strong-field GR tests

We report on the high precision timing analysis of the pulsar-white dwarf binary PSR J1012+5307. Using 15 years of multi-telescope data from the European Pulsar Timing Array (EPTA) network, a significant measurement of the variation of the orbital period is obtained. Using this ideal strong-field gravity laboratory we derive theory independent limits for both the dipole radiation and the variation of the gravitational constant.Comment: 3 pages, Proceedings of the 12th Marcel Grossmann Meeting on General Relativity (MG 12

Rapid Targeted Gene Disruption in Bacillus Anthracis

Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen. The ease with which the bacterium can be weaponized and its recent deliberate use as an agent of terror, have highlighted the importance of gaining a deeper understanding and effective countermeasures for this important pathogen. High quality sequence data has opened the possibility of systematic dissection of how genes distributed on both the bacterial chromosome and associated plasmids have made it such a successful pathogen. However, low transformation efficiency and relatively few genetic tools for chromosomal manipulation have hampered full interrogation of its genome. Results: Group II introns have been developed into an efficient tool for site-specific gene inactivation in several organisms. We have adapted group II intron targeting technology for application in Bacillus anthracis and generated vectors that permit gene inactivation through group II intron insertion. The vectors developed permit screening for the desired insertion through PCR or direct selection of intron insertions using a selection scheme that activates a kanamycin resistance marker upon successful intron insertion. Conclusions: The design and vector construction described here provides a useful tool for high throughput experimental interrogation of the Bacillus anthracis genome and will benefit efforts to develop improved vaccines and therapeutics.Chem-Bio Diagnostics program from the Department of Defense Chemical and Biological Defense program through the Defense Threat Reduction Agency (DTRA) B102387MNIH GM037949Welch Foundation F-1607Cellular and Molecular Biolog