The basic biology of erbB-2 and its participation in colorectal cancers

ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers are formed and cell signalling is stronger, resulting in enhanced responsiveness to growth factors and malignant growth. This explains why ErbB-2 overexpression is an indicator of poor prognosis in colorectal cancers and may be predictive of response to treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej naukę

Oromandibular Dysfunction Among Dental Students

The aim of the study was to determine frequency of oromandibular dysfunction among dental students. A total of 186 second and third year students (131 women and 55 men) aged 19-31 years (M=23) were examined, using the Gerber System instrumental technique. Oromandibular dysfunction was diagnosed according to IHS and AAOP criteria. T-TH was found in 58% of students, occlusal parafunction in 58%, non-occlusal parafunction in 84%. Tooth numbness occurred in 20% of subjects, masticatory muscle soreness on palpation in 28%, muscle hypertrophy in 14%. TMJ acoustic sounds were noticed in 55% of students, TMJ pain in 31%, limited mandibular movement while opening the mouth in 37%. All students examined had premature occlusal contacts, they were asymmetric in 98%. Oromandibular dysfunction was diagnosed in 79%, 21% of which had 6 or more dysfunction signs and symptoms, 19% had only one or two of them. The Eysenck personality questionnaire, additionally used in the study, revealed different types of personalities among students. Conclusion: Oromandibular dysfunction symptoms were observed in most ofstudents. They should be associated with school induced stress and not with the personality type of the subjects examined

On the families of orthogonal polynomials associated to the Razavy potential

We show that there are two different families of (weakly) orthogonal polynomials associated to the quasi-exactly solvable Razavy potential V(x)=(\z \cosh 2x-M)^2 (\z>0, $M\in\mathbf N$). One of these families encompasses the four sets of orthogonal polynomials recently found by Khare and Mandal, while the other one is new. These results are extended to the related periodic potential U(x)=-(\z \cos 2x -M)^2, for which we also construct two different families of weakly orthogonal polynomials. We prove that either of these two families yields the ground state (when $M$ is odd) and the lowest lying gaps in the energy spectrum of the latter periodic potential up to and including the $(M-1)^{\rm th}$ gap and having the same parity as $M-1$. Moreover, we show that the algebraic eigenfunctions obtained in this way are the well-known finite solutions of the Whittaker--Hill (or Hill's three-term) periodic differential equation. Thus, the foregoing results provide a Lie-algebraic justification of the fact that the Whittaker--Hill equation (unlike, for instance, Mathieu's equation) admits finite solutions.Comment: Typeset in LaTeX2e using amsmath, amssymb, epic, epsfig, float (24 pages, 1 figure

Revitalization of selected brownfields in urban space of Skierniewice with particular emphasis on environmentally friendly elements.

Transformation of urban space is a result of constant changes, which can also lead to a deterioration of the state of such space. City revitalization programs allow for the release of brownfields from crisis situations and adapting them to the needs of local communities, with particular emphasis on environmentally friendly elements. The aim of the article was to present the concept of revitalization activities, proposed for introduction in the brownfield site, in the city of Skierniewice, currently used by Stal-Car. These activities include treatments that can result in the creation of urban public spaces with environmentally friendly elements.Przekształcenie przestrzeni miejskiej to efekt ciągłych przemian, które mogą prowadzić również do pogorszenia jej stanu. Programy rewitalizacji miast pozwalają na wyprowadzenie ze stanu kryzysowego m.in. terenów poprzemysłowych i dostosowanie ich do wymogów lokalnych społeczności, ze szczególnym uwzględnieniem elementów przyjaznych środowisku. W artykule za cel przyjęto stworzenie koncepcji działań rewitalizacyjnych proponowanych do wprowadzenia na terenie poprzemysłowym w Skierniewicach, obecnie użytkowanym przez firmę Stal-Car. Działania te obejmują zabiegi, których następstwem może być powstanie miejskiej przestrzeni publicznej z elementami przyjaznymi środowisku