ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission
of signals controlling normal cell growth and differentiation. A range of growth
factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to
ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference
for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers
are formed and cell signalling is stronger, resulting in enhanced responsiveness to
growth factors and malignant growth. This explains why ErbB-2 overexpression is an
indicator of poor prognosis in colorectal cancers and may be predictive of response to
treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 dofinansowane zostało ze środków MNiSW w ramach działalności upowszechniającej naukę
