Khat use in persons with mental illness in Southwest Ethiopia: a cross- sectional study

Yosef Zenebe, Garumma Tolu Feyissa and Wolfgang Krah

LIFE-SHARE Project: Developing a Digitisation Strategy Toolkit

This poster will outline the Digitisation Strategy Toolkit created as part of the LIFE-SHARE project. The toolkit is based on the lifecycle model created by the LIFE project and explores the creation, acquisition, ingest, preservation (bit-stream and content) and access requirements for a digitisation strategy. This covers the policies and infrastructure required in libraries to establish successful practices. The toolkit also provides both internal and external resources to support the service. This poster will illustrate how the toolkit works effectively to support digitisation with examples from three case studies at the Universities of Leeds, Sheffield and York

Alcohol use disorders and its associated factors among psychiatric Outpatients in Jimma University Specialized Hospital, Southwest Ethiopia

Background: Worldwide, alcohol consumption caused 3.8 percent of all deaths and 4.5 percent of the total burden of disease in 2004. Alcohol use disorders (AUDs) are also a burden for individuals and society in Ethiopia. It is important to identify problematic alcohol use at an early stage, as this provides professionals with the opportunity to take preventive measures and, hence, reduce the problems caused by this consumption. The high prevalence of substance abuse problems among persons with psychiatric disorders calls for more effective alcohol and drug use assessment in psychiatric settings. Objectives: To assess prevalence of alcohol use disorders and its associated factors among psychiatric outpatients in Jimma University specialized hospital (JUSH) Methods: A university hospital based cross-sectional study of 365 psychiatric outpatients was conducted from 1st to 15th August 2013 in Jimma zone, south-west Ethiopia. The data were collected by interviewing all psychiatric outpatients coming for treatment at JUSH by using structured questionnaire. An alcohol use disorder was assessed using Alcohol Use Disorders Identification Test (AUDIT). All variables associated with AUDs with a p value ≤ 0.25 were included in the final multivariable model. Results: The estimated prevalence rate of AUD was 38.9%, with 23.3% hazardous drinking, 5.8% alcohol abuse and 9.8% alcohol dependence. In the final multiple logistic regression model AUD was significantly associated with Gender, Religion, Frequency of going to worship places and Cigarette smoking. Being female gender was less likely to develop AUD. Those who were orthodox religion followers, those who never went to the worship places and those who smoke cigarettes were more likely to have AUD. Conclusions: The high prevalence of AUDs detected in our facility-based survey of psychiatric outpatients in Ethiopia implies the need to design effective screening tools and feasible interventions for AUDs.Zenebe Y, Negash A, Feyissa GT and Krahl

Empathy without borders? Cross-cultural heart and mind-reading in first-year medical students

Background: This cross-cultural study was designed to examine cultural differences in empathy levels of first-year medical students.Methods: A total of 257 students from the academic year 2010/11, 131 at Jimma University, Ethiopia, and 126 at the Ludwig Maximilian University, Munich, Germany, completed the Balanced Emotional Empathy Scale (BEES), the Reading the Mind in the Eyes (RME-R) test, and a  questionnaire on sociodemographic and cultural characteristics. Furthermore, we conducted a qualitative analysis of the students’ personal views on the definition of empathy and possible influencing factors. Group comparisons and correlation analyses of empathy scores were performed for the entire cohort and for the Jimma and Munich students separately. We used a regression tree analysis to identify factors influencing the BEES.Results: The male students in Jimma (39.1 ± 22.3) scored significantly higher in the BEES than those male students from Munich (27.2 ± 22.6; p = 0.0002). There was no significant difference between the female groups. We found a moderate, positive correlation between the BEES and RME-R test, i.e. between emotional and cognitive empathy, within each university. Nevertheless, the RME-R test, which shows only Caucasian eyes, appears not to be suitable for use in other cultures.Conclusions: The main findings of our study were the influence of culture, religion, specialization choice, and gender on emotional empathy (assessed with the BEES) and cognitive empathy (assessed with the RME-R test) in first-year medical students. Further research is required into the nature of empathy in worldwide medical curricula.Keywords: Balanced Emotional Empathy Scale, Cross-cultural, Empathy, Medical Student

Diagnóstico nutricional de uma lavoura de soja a partir de informações georreferenciadas.

RESUMO: Neste trabalho, objetivou-se identificar os fatores relacionados à produtividade da soja, utilizando informações georreferenciadas sobre o estado nutricional das plantas, atributos do solo e produtividade da cultura. Uma área de 27,5 hectares foi dividida em grade amostral regular de 50 x 50m para coletas de folhas e do solo para análise. A colheita foi monitorada por meio de uma colhedora equipada com sensor de produtividade e DGPS. Os resultados das análises de solo e de folhas foram interpretados agronomicamente e correlacionados entre si e com a produtividade. Foram gerados mapas representando a espacialização das variáveis mais relevantes. Não foram obtidas correlações significativas dos teores foliares de nutrientes com as características do solo ou com a produtividade. Na lavoura estudada, os teores da matéria orgânica e potássio no solo e a saturação do potássio na CTC são os atributos mais relacionados com a produtividade da soja. ABSTRACT: The aim of this study was to identify yield conditioning factors of a soybean crop, based on georreferenced information concerning the plant nutritional status, soil attributes, and crop yield. An area of 27,5 ha was divided in a regular grid of 50 x 50m for colecting leaf and soil samples. The harvest was done using yield monitor and DGPS. Soil, plant, and yield data were interpreted on the agronomic basis, and submitted to correalation analysis. The spatial variation of the most important variables was mapped. It was not found any significant correlation among leaf nutrient concentrations and soil characteristics or yield. The soil organic matter and potassium contents, as well as the CEC potassium saturation, were the variables most correlated with the soybean yield.bitstream/CPAC-2009/27660/1/bolpd_145.pd

Improving the Efficiency of Physical Examination Services

The objective of our project was to improve the efficiency of the physical examination screening service of a large hospital system. We began with a detailed simulation model to explore the relationships between four performance measures and three decision factors. We then attempted to identify the optimal physician inquiry starting time by solving a goal-programming problem, where the objective function includes multiple goals. One of our simulation results shows that the proposed optimal physician inquiry starting time decreased patient wait times by 50% without increasing overall physician utilization

Excitonic recombination dynamics in shallow quantum wells

We report a comprehensive study of carrier-recombination dynamics in shallow AlxGa1-xAs/GaAs quantum wells. At low crystal temperature (2 K), the excitonic radiative recombination time is shown to be strongly enhanced in shallow quantum wells with x>0.01, consistently with a model that takes into account the thermal equilibrium between the three-dimensional exciton gas of the barrier and the two-dimensional exciton gas, which are closer in energy as x decreases. Furthermore, we demonstrate the existence of a thermally activated escape mechanism due to the low effective barrier height in these structures. The nonradiative recombination is shown to dominate the carrier dynamics for temperatures as low as 10 K for x≈0.01. Our experimental observations are analyzed using three different variational exciton calculations. In particular, we study the crossover from the two-dimensional to the three-dimensional behavior of the exciton, which occurs for x as low as 0.01 and affects mainly the oscillator strength, whereas the transition energies in shallow quantum wells can be calculated, to a large extent, using the same approximations as for conventional quantum wells. The peculiar behavior of the oscillator strength at the crossover to the weak confinement regime is obtained by expansion in a large basis

Zum biochemischen Wirkungsmechanismus des adrenocorticotropen Hormons

Es wird eine Übersicht über zwei Hypothesen und die dazugehörigen Befunde zum Wirkungsmechanismus des adrenocorticotropen Hormons gegeben: 1. Der Gehalt der Nebenniere an cyclischem Adenosinmonophosphat wird durch ACTH erhöht, die stimulierende Wirkung des Hormons auf die Corticoidsynthese wird durch cyclisches Adenosinmonophosphat imitiert. Die Beschleunigung der Corticoidsynthese dürfte allerdings nicht durch eine Aktivierung der Phosphorylase in der Nebenniere erfolgen. 2. Befunde zum biochemischen Mechanismus der Stimulation der Proteinsynthese in der Nebenniere durch ACTH werden referiert. Die Intaktheit der Proteinsynthese der Nebenniere scheint für den steroidogenen Effekt des ACTH Voraussetzung zu sein.Two current hypotheses on the mechanism of action of ACTH are reviewed: 1. The content of cyclic 3,5-adenosine monophosphate of the adrenals is increased by ACTH, and cyclic AMP or ACTH enhance corticoid synthesis. However, stimulation of corticoid synthesis presumably is not mediated by activation of adrenal phosphorylase. 2. Experiments dealing with the biochemical mechanism of the stimulation of adrenal protein synthesis are reviewed. The integrity of the adrenal protein synthesis appears to be necessary for the enhancement of corticoid synthesis by ACTH

Immunohistochemical analysis of the mechanistic target of rapamycin and hypoxia signalling pathways in basal cell carcinoma and trichoepithelioma

Background: Basal cell carcinoma (BCC) is the most common cancer in Caucasians. Trichoepithelioma (TE) is a benign neoplasm that strongly resembles BCC. Both are hair follicle (HF) tumours. HFs are hypoxic microenvironments, therefore we hypothesized that hypoxia-induced signalling pathways could be involved in BCC and TE as they are in other human malignancies. Hypoxia-inducible factor 1 (HIF1) and mechanistic/mammalian target of rapamycin (mTOR) are key players in these pathways. Objectives: To determine whether HIF1/mTOR signalling is involved in BCC and TE. Methods: We used immunohistochemical staining of formalin-fixed paraffin-embedded BCC (n = 45) and TE (n = 35) samples to assess activity of HIF1, mTORC1 and their most important target genes. The percentage positive tumour cells was assessed manually in a semi-quantitative manner and categorized (0%, 80%). Results: Among 45 BCC and 35 TE examined, expression levels were respectively 81% and 57% (BNIP3), 73% and 75% (CAIX), 79% and 86% (GLUT1), 50% and 19% (HIF1 alpha), 89% and 88% (pAKT), 55% and 61% (pS6), 15% and 25% (pMTOR), 44% and 63% (PHD2) and 44% and 49% (VEGF-A). CAIX, Glut1 and PHD2 expression levels were significantly higher in TE when only samples with at least 80% expression were included. Conclusions: HIF and mTORC1 signalling seems active in both BCC and TE. There are no appreciable differences between the two with respect to pathway activity. At this moment immunohistochemical analyses of HIF, mTORC1 and their target genes does not provide a reliable diagnostic tool for the discrimination of BCC and TE