Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin alpha5beta1

Toxicolog

Animal products and K-ras codon 12 and 13 mutations in colon carcinomas

K-ras gene mutations (codons 12 and 13) were determined by PCR-based mutant allele-specific amplification (MASA) in tumour tissue of 185 colon cancer patients: 36␑arboured mutations, of which 82 ere located in codon 12. High intakes of animal protein, calcium and poultry were differently associated with codon 12 and 13 mutations: odds ratios (OR) and 95␌onfidence intervals (95␌I) for codon 12 versus codon 13 were 9.0 (2.0–42), 4.1 (1.4–12) and 15 (1.4–160), respectively. In case–control comparisons, high intakes of animal protein and calcium were positively associated with colon tumours harbouring codon 12 mutations [for animal protein per 17 g, OR (95␌I) = 1.5 (1.0–2.1); for calcium per 459 mg, 1.2 (0.9–1.6)], while inverse associations were observed for tumours with K-ras mutations in codon 13 [for animal protein 0.4 (0.2–1.0); for calcium 0.6 (0.3–1.2)]. Transition and transversion mutations were not differently associated with these dietary factors. These data suggest a different dietary aetiology of colon tumours harbouring K-ras codon 12 and 13 mutations

Integrin beta-3 cDNA transfection into a highly metastatic alpha-v beta-3 negative human melanoma cell line inhibits invasion and experimental metastasis,Integrin β3 cDNA Transfection into a Highly Metastatic αvβ3-Negative Human Melanoma Cell Line Inhibits Invasion and Experimental Metastasis

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α-integrins in human melanoma : gain of α v β 3 and loss of α v β 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice,Alpha-integrins in human melanoma : gain of alpha v beta 3 and loss of alpha v beta 5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice

Contains fulltext : 21552___.PDF (publisher's version ) (Open Access

Reduction of heparan sulphate-associated anionic sites in the glomerular basement membrane of rats with streptozotocin-induced diabetic nephropathy

Contains fulltext : 21019___.PDF (publisher's version ) (Open Access

Integrin betha-3 cDNA transfection into a highly metastatic alpha-v betha-3 negative human melanoma cell line inhibits invasion and experimental metastasis

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Vessel wall heparan sulfate and transcapillary passage of albumin in experimental diabetes in the rat

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The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma.

Contains fulltext : 187661.pdf (publisher's version ) (Closed access)The existence of XAGE genes was first reported after database homology searches for PAGE-like sequences identified 3 XAGE EST clusters. One of these clusters, XAGE-1, has in later studies been identified as a cancer/testis-associated gene. Here, we report the expression profiles of all 3 reported XAGE genes, as well as several splice variants of XAGE-1, in normal human tissues, Ewing's sarcoma and melanocytic tumors. We also provide the genetic structure of the corresponding genes. Moreover, by searching the databases for XAGE homologues, we identified 3 additional GAGE-like genes. RT-PCR studies showed frequent expression in melanoma metastases and Ewing's sarcoma for 2 XAGE-1-derived transcripts. XAGE-2 was expressed at lower frequency in these tissues, while XAGE-3 was seen only in normal placenta. Due to a frameshift, the largest XAGE-1 putative protein is far less homologous to GAGE-like proteins than the other XAGEs. Interestingly, all GAGE-like genes contain a large secondary open reading frame, coding for putative proteins homologues to the XAGE-1 primary protein. The XAGE family of cancer/testis-associated genes is located on chromosome Xp11.21-Xp11.22. The data outline a superfamily of GAGE-like cancer/testis antigens, consisting of at least 19 genes

Ó-Integrins in human melanoma: gain of Óvß3 and loss of Óvß5 are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice

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