ЭРОЗИЯ КОМПЕТЕНЦИЙ ИННОВАЦИОННЫХ ПРОЕКТОВ ДИГИТАЛИЗАЦИИ

Рассмотрены структура и функции механизмов развития и эрозии (размывания) компетенций в инновационных проектах по внедрению информационно-коммуникационных технологий в дигитализации общества. Определены факторы развития и эрозии компетенций. Была построена модель оценки компетенций и компетенций для успешного внедрения информационных и коммуникационных технологий на примере программ управления проектами и оцифровки. Предлагаемая модель развития компетенций проектной команды по созданию и внедрению основана на балансе факторов развития компетенций инновационного проекта и их эрозии в процессе реализации. Изучение факторов развития и эрозии компетенций в управлении инновационными проектами по дигитализации позволяет адекватно реагировать на изменения в профиле компетенций инновационных проектов. В то же время анализ позволяет руководителю проекта формировать эффективные программы для приобретения определенных компетенций для членов команды и других заинтересованных сторон. Предложенная модель факторов развития и эрозии системы компетенций проверена на примерах, подтверждающих ее адекватность и эффективность. Эта модель развития и эрозии компетенций команды проекта по дигитализации основана на балансе факторов для развития компетенций инновационного проекта и их размывания в процессе реализации. Изучение факторов развития и размывания компетенций в управлении инновационными проектами позволяет нам адекватно реагировать на изменения в профиле компетенций инновационных проектов. В то же время анализ позволяет руководителю проекта формировать эффективные программы для приобретения определенных компетенций для членов команды и других заинтересованных сторон. Предложенная авторами модель факторов развития и размывания системы компетенций проверяется на примерах применения методологии Agile на уровне кафедры управления проектами Киевского национального университета строительства и архитектуры. Реализация подтвердила адекватность и эффективность модели и методов анализа развития и размывания компетенций и, как следствие, компетентности. В качестве направления для дальнейшего развития необходимо определить методы и алгоритмы активного реагирования Лидера на развитие, и эрозию компетенций, формируя соответствующие компетенции членов команды, обеспечивающие успех инновационных проектов

Modeling processes in IDEF0 (Integration Definition for Function Modeling). Lab manual for the course of "Modeling and reengineering business processes" for students specialized in fild of stady 124 – System analisis

Методичні рекомендації мають на меті допомогти студентам у самостійному засвоєнні дисципліни «Моделювання та реінжиніринг бізнес-процесів» під час виконання індивідуальних робіт і набуття навичок роботи у середовищі AllFusion Process Modeler. Вони орієнтовані на поглиблення та закріплення теоретичних засад структурного, процесного та об'єктно-орієнтованого підходів до аналізу бізнес-процесів з подальшим їх моделюванням за допомогою CASE-засобів. Рекомендації орієнтовано на активізацію виконавчого етапу навчальної діяльності студентів спеціальності 124 – Cистемний аналіз.The objective of the lab manual is to help students independently master the optional discipline "Modeling and reengineering business processes" while doing the individual task and learning how to deal with AllFusion Process Modeler. The lab manual is aimed at deepening and consolidating the theoretical knowledge on structural, process and object-oriented approaches to the business processes analysis; learning how to apply the methods of analysis for business process modelling; mastering the modelling methods with the help of the CASE-tools. The manual is aimed at activating the executive stage of students' educational activities fild of stady 124 – System analisis

An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

The Surface Ocean CO₂ Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO₂ (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO₂ values) and extended data coverage (from 1968–2007 to 1968–2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longerterm variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models

An update to the Surface Ocean CO2 Atlas (SOCAT version 2)

The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO(2) (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO(2) values) and extended data coverage (from 1968-2007 to 1968-2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longer-term variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models.</p

Клинико-экспериментальное обоснование выбора платформы первого отечественного стента с лекарственным покрытием

Background.The availability of drug-eluting stents with evidence-based clinical safety and efficacy produced in the Russian Federation is one of the relevant goals for successful treating of patients with coronary artery disease, including acute coronary syndrome. Aim To confirm clinical rationale and experimental feasibility of the first Russian drugeluting stent, Calypso (Angioline, LLC, Russian Federation), for the clinical practice.Methods.The study included four phases. The first phase was aimed at selecting the optimal stent platform with superior healing properties. Then, the selected Russian coronary stents based on the optimal platforms underwent preclinical studies. The third phase included the clinical assessment using optical coherence tomography (OCT) in order to confirm the preclinical results. The last phase was focused on assessing clinical safety and efficacy of the Russian coronary stent based on the comparative analysis of angiographic findings within the 12-months follow-up.Results.At the first phase, biodegradable polymer sirolimus-eluting stent showed superior healing properties in comparison with the healing score of 18±14.97 for Orsiro stents (Biotronik, Germany) versus 25.6±1.0 for Xience stents (Abbott Vascular, USA) versus 32.5±20.3 for Synergy (Boston Scientific, USA), p&lt;0.001. The Russian stent consistently demonstrated a high healing profile in preclinical and OCT clinical studies. The results of the comparative clinical study proved the clinical safety and efficacy of the Russian stent that was similar to the best foreign stents. None of the differences in the incidence of binary restenosis were found between the groups (p&lt;0.05).Conclusion.The biodegradable polymer sirolimus-eluting stent Calypso manufactured in the Russian Federation demonstrated superior neointimal healing pattern with no signs of chronic inflammation in the experiment. This stent reported high neointimal healing properties according to the clinical OCT study. According to the angiographic findings, the incidence of binary restenosis between the Russian biodegradable polymer sirolimus-eluting stent and durable polymer everolimuseluting stents was similar at the 12-months follow-up (p&gt;0.05).Актуальность.Актуальность работы обусловлена необходимостью доступных российских лекарственных стентов с доказанной клинической безопасностью и эффективностью для лечения пациентов с ишемической болезнью сердца, в том числе острым коронарным синдром.Цель.Клинико-экспериментальное обоснование внедрения в широкую клиническую практику отечественного коронарного стента «Калипсо» (ООО «Ангиолайн», Россия).Материалы и методы.Научно-исследовательская работа выполнена в четыре этапа. Первый этап включал исследование, направленное на поиск платформы стента с наилучшими показателями заживления. Далее проведено доклиническое исследование отечественных коронарных стентов, в основе которых лежала платформа, показавшая наилучший результат на первом этапе. В рамках третьего этапа с целью подтверждения доклинических результатов проведено клиническое исследование с использованием оптической когерентной томографии. Финальная часть работы, целью которой было подтверждение эффективности и безопасности российского стента в клинической практике, включала сравнительный анализ ангиографических данных через 12 мес. после начала исследования.Результаты.На первом этапе платформа стента с биодеградируемым покрытием, выделяющим сиролимус, показала наиболее высокий профиль заживления в сравнении с другими исследуемыми платформами: показатель шкалы неоинтимального заживления для группы стента Orsiro (Biotronik, Германия) составил 18,0±14,97 в сравнении с группой Xience (Abbott Vascular, США) 25,6±1,0 и Synergy (Boston Scientific, США) 32,5±20,3 (p&lt;0,001). Отечественный аналог последовательно продемонстрировал высокий профиль заживления в доклиническом и клиническом исследованиях с применением оптической когерентной томографии. Результаты финального, сравнительного, клинического исследования показали, что российский стент обладает сопоставимым профилем безопасности и эффективности в сравнении с одним из лучших зарубежных стентов (статистически значимой разницы по частоте бинарного рестеноза между группами не выявлено, p&gt;0,05).Заключение.Отечественный сиролимус-покрытый стент с биодеградируемым полимером «Калипсо» продемонстрировал показатели полного неоинтимального заживления без признаков хронического воспаления в эксперименте. Данный стент характеризовался высоким уровнем неоинтимального заживления по данным клинического исследования с использованием ОКТ. По данным ангиографического контроля не выявлено статистически значимой разницы в частоте бинарного рестеноза между российским сиролимус-выделяющим стентом с биодеградируемым покрытием и эверолимус-выделяющим стентом с постоянным полимером через 12 мес. после имплантации (р&gt;0,05)

Antibody Responses against Xenotropic Murine Leukemia Virus-Related Virus Envelope in a Murine Model

Xenotropic murine leukemia virus-related virus (XMRV) was recently discovered to be the first human gammaretrovirus that is associated with chronic fatigue syndrome and prostate cancer (PC). Although a mechanism for XMRV carcinogenesis is yet to be established, this virus belongs to the family of gammaretroviruses well known for their ability to induce cancer in the infected hosts. Since its original identification XMRV has been detected in several independent investigations; however, at this time significant controversy remains regarding reports of XMRV detection/prevalence in other cohorts and cell type/tissue distribution. The potential risk of human infection, coupled with the lack of knowledge about the basic biology of XMRV, warrants further research, including investigation of adaptive immune responses. To study immunogenicity in vivo, we vaccinated mice with a combination of recombinant vectors expressing codon-optimized sequences of XMRV gag and env genes and virus-like particles (VLP) that had the size and morphology of live infectious XMRV.Immunization elicited Env-specific binding and neutralizing antibodies (NAb) against XMRV in mice. The peak titers for ELISA-binding antibodies and NAb were 1:1024 and 1:464, respectively; however, high ELISA-binding and NAb titers were not sustained and persisted for less than three weeks after immunizations.Vaccine-induced XMRV Env antibody titers were transiently high, but their duration was short. The relatively rapid diminution in antibody levels may in part explain the differing prevalences reported for XMRV in various prostate cancer and chronic fatigue syndrome cohorts. The low level of immunogenicity observed in the present study may be characteristic of a natural XMRV infection in humans

An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO2 (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3 million to 10.1 million surface water fCO2 values) and extended data coverage (from 1968–2007 to 1968–2011). The quality control criteria, while identical in both versions, have been applied more strictly in version 2 than in version 1. The SOCAT website (http://www.socat.info/) has links to quality control comments, metadata, individual data set files, and synthesis and gridded data products. Interactive online tools allow visitors to explore the richness of the data. Applications of SOCAT include process studies, quantification of the ocean carbon sink and its spatial, seasonal, year-to-year and longerterm variation, as well as initialisation or validation of ocean carbon models and coupled climate-carbon models

Innovative technology of obtaining organic marble beef

The aim was to develop an innovative technology for obtaining high-quality organic marble beef. In the experimental farm “Polyvanivka” of the Institute of Grain Crops NAAS the cultivation of bulls of the gray Ukrainian breed up to 30 months of age has been organized using fodder which is traditional for steppe zone of Ukraine. The work has been performed according to the research program of the National Academy of Agrarian Sciences of Ukraine no. 37 “System of work in populations and conservation of biological diversity of genetic resources of farm animals” (“Preservation of breed gene pool”). The expediency of organic production of high-quality marble beef obtained in the steppe zone of Ukraine from gray Ukrainian cattle has been proven. This breed has such economically useful features as the duration of production use, longevity, high growth energy (stable average daily gain over 1 kg), and the conversion of diet into products (feed consumption is 70–80 MJ per 1 kg of growth) correlating with the age of the animal, slaughter rates (>60%, meat content is >4 kg per 1 kg of bones, hard skin is >30 kg which belongs to the category of bull production). We have found that it is necessary to determine the cattle fatness not by subcutaneous fat which has no dietary value, but by the beef marbling as a sign of its quality which takes into account the presence of intramuscular and intermuscular fat including unsaturated fatty acids, vitamins A and D, as well as the amount of protein and moisture and taste and culinary features of the carcass flesh, such as tenderness, juiciness and aroma. This meets the requirements of the consumer. The proposals based on the results of research on technological changes in animal husbandry promote the development of meat cattle breeding and are of great economic importance for strengthening the health of the population and food safety in Ukraine

Feed protein solubility as an indicator of digestibility and availability of nutrients in the diets of bulls

The research was conducted on steppe red bulls with duodenal and ileocecal anastomoses when feeding isoenergetic, isoprotein hay-concentrate diets with different levels of soluble protein (SP) and rumen degradable protein (RDP). We studied the transformation of dry matter (DM), organic matter (OM), crude protein (CP), crude ash (CA), crude fat (CF), crude fiber (CF) and nitrogen-free extractives (NFE) separately in a complex stomach, small (SI) and large (LI) parts of the intestine. Assimilation of protein by animals was assessed by the amount of it digested in SI, and unproductive costs — by the part of nitrogen in the urine. Diets consisted of hay, peas and mineral supplements. Different amounts of SP in the diets were achieved by feeding natural pea (control) or pea grilled at a temperature of +105°C (experiment). When feeding a diet with a reduced level of SP and RDP, the apparent intensity of digestion decreased, which was manifested in a slightly smaller amount of feed consumed, and in a smaller number of duodenal and ileocecal chyme. In a complex stomach, the CP digestibility of the experimental diet with a reduced level of SP was 10% lower. In the control diet with a high level of SP, more CP was degraded in rumen and more ammonium nitrogen was supplied to SI. The availability of CP for digestion in SI on the experimental diet was 5.8% higher, against control, with 8–10% higher digestibility of DM, OM and CP, but lower digestibility of CA and CF. In LI, the digestibility of nutrients in the studied diets was multidirectional. A significant amount of dietary protein was depreciated in the control diet with a high level of SP due to a 40% increase in urinary nitrogen excretion

Productivity energy level of cows of Gray Ukrainian breeds and their reproductive qualities

We have studied the reproductive abilities of the animals and the development of the offspring during the post-sucking period on cows of the Gray Ukrainian breed in the 1st–3rd lactations. To evaluate the cows and the offspring, in addition to traditional signs, indicators of net energy of body maintenance and net energy of growth were introduced, as integrated indicators of the state of the organism, which depend to a greater extent on the origin than on the conditions of keeping. We have established that the researched population of animals of the Gray Ukrainian breed in the ecological and fodder conditions of the steppe zone of Ukraine shows excellent maternal instincts, reproductive function and small foetus rate not lower than the standard for the breed, almost equal distribution of offspring by sex. The yield of calves per 100 cows is 97–98%, live weight of calves at birth is 25–26 kg for heifers and 27–28 kg for bulls; high milk yield: the weaning live weight at 8 months of age is 200 kg for heifers and 230 kg for bulls, the service period of cows for 1–3 lactation period is 155–91 days, the intercalving period is 433–371 days, the small foetus coefficient is 0.54–0.49, net energy for maintaining vital activity in cows is 40–45 MJ and in newborn calves — 4.5–4.6 MJ, the net energy of growth of young calves when weaned from their mothers is 19–20 MJ and for the entire period of suckling is 3800–4900 MJ. In the section of lactations, correlational dependences were established between the net energy of maintaining cows and their offspring, which makes it possible to carry out more purposeful selection and selection of animals for further breeding and preservation of the herd of this breed