Sand, salt, and models : The legacy of Bruno Vendeville

Acknowledgements We are grateful for the support of numerous colleagues who contributed, either materially or simply with encouragement, to putting together this memorial to our friend Bruno. The important task of reviewing and editing manuscripts was carried out by the co-editors along with Jürgen Adam, Ian Davison, Tim Dooley, Carl Fiduk, Pablo Granado, Geoffroy Mohn, Webster Mohriak, Van Mount, Josep Anton Muñoz, Thierry Nalpas, Fabrizio Storti, Gabor Tari, Lei Wu, and 16 reviewers who chose to remain anonymous. And of course, this volume would not have happened without the hard work and persistence of the many authors and coauthors who contributed their manuscripts. We also thank Lorna Stewart and other staff at the Journal of Structural Geology for their help and guidance, as well as Tim Dooley for supplying original versions of the figures used here.Peer reviewe

Do diagnostic delays in cancer matter?

background: The United Kingdom has poorer cancer outcomes than many other countries due partly to delays in diagnosing symptomatic cancer, leading to more advanced stage at diagnosis. Delays can occur at the level of patients, primary care, systems and secondary care. There is considerable potential for interventions to minimise delays and lead to earlier-stage diagnosis. methods: Scoping review of the published studies, with a focus on methodological issues. results: Trial data in this area are lacking and observational studies often show no association or negative ones. This review offers methodological explanations for these counter-intuitive findings. conclusion: While diagnostic delays do matter, their importance is uncertain and must be determined through more sophisticated methods

Non-small-cell lung cancer in a French department, (1982–1997): management and outcome

Addition of chemotherapy to the treatment of non-small-cell lung cancer (NSCLC) resulted in a modest but clear improvement in the survival of selected patients. To ascertain if this translates to improved survival in the whole population of patients, we conducted a retrospective population-based study of a sample of 1738 patients diagnosed with primary NSCLC in a French department between 1982 and 1997. The proportion of women, metastatic cases and adenocarcinoma changed significantly over time, as did their management: use of chemotherapy alone increased from 9.7 to 28.1% (P<0.0001), while the use of radiotherapy alone decreased from 32.2 to 9.4% (P<0.0001). The 5-year survival probability was 15.7 % for all patients and 32.6% for those with resectable disease. The 1- and 2-year survival probabilities were 38.2 and 15.6% in locally advanced disease, and were, respectively, 16.8 and 5.2% in metastatic disease. Disease extent and histological subtype were significant independent prognostic factors. Survival of resectable disease was longer among patients treated with surgery or surgery plus chemotherapy, while better outcomes for locally advanced disease were associated with radiation plus chemotherapy. In metastastic disease, patients treated by classical agent without platin or palliative care only had the shortest survival. Despite changes in treatment in accordance with the state-of-the-art, overall survival did not improve over time. It is not unlikely that more patients with bad PS were diagnosed during the latter end of the study period. This could at least partially explain the absence of detection of an overall improvement in survival

Previous Lung Diseases and Lung Cancer Risk: A Systematic Review and Meta-Analysis

In order to review the epidemiologic evidence concerning previous lung diseases as risk factors for lung cancer, a meta-analysis and systematic review was conducted.Relevant studies were identified through MEDLINE searches. Using random effects models, summary effects of specific previous conditions were evaluated separately and combined. Stratified analyses were conducted based on smoking status, gender, control sources and continent.A previous history of COPD, chronic bronchitis or emphysema conferred relative risks (RR) of 2.22 (95% confidence interval (CI): 1.66, 2.97) (from 16 studies), 1.52 (95% CI: 1.25, 1.84) (from 23 studies) and 2.04 (95% CI: 1.72, 2.41) (from 20 studies), respectively, and for all these diseases combined 1.80 (95% CI: 1.60, 2.11) (from 39 studies). The RR of lung cancer for subjects with a previous history of pneumonia was 1.43 (95% CI: 1.22-1.68) (from 22 studies) and for subjects with a previous history of tuberculosis was 1.76 (95% CI=1.49, 2.08), (from 30 studies). Effects were attenuated when restricting analysis to never smokers only for COPD/emphysema/chronic bronchitis (RR=1.22, 0.97-1.53), however remained significant for pneumonia 1.36 (95% CI: 1.10, 1.69) (from 8 studies) and tuberculosis 1.90 (95% CI: 1.45, 2.50) (from 11 studies).Previous lung diseases are associated with an increased risk of lung cancer with the evidence among never smokers supporting a direct relationship between previous lung diseases and lung cancer

The role of multiple weak lithologies in the deformation of cover units in the northwestern segment of the zagros fold-and-thrust belt

The geometry, kinematics and dynamics of fold-and-thrust belts are strongly influenced by the mechanical behaviour of the basal decollement. However, many fold-and-thrust belts also include mechanically weak lithologies such as evaporites and marls or mudstones at different levels within the shortened stratigraphy. The kinematics and dynamic evolution of these thrust belts are controlled by the mechanical behaviour both of the basal decollement and of the weak units embedded within the overlying stratigraphic succession. In the Zagros fold-and-thrust belt (ZFTB), the shortened sedimentary cover is between 7 and 12 km thick and mechanically weak lithologies compartmentalize the stratigraphic column at shallow and intermediate levels. In this paper, satellite, field and seismic data from the Kurdistan Region of Iraq are used to identify structures of different sizes and surface traces. The observations are used to underline the role of mechanically weak horizons within the Zagros stratigraphy and the decoupling of deformation both laterally and with depth in the belt. The decoupling between shallow and deeper structures observed in seismic profiles from the Kurdistan Region of Iraq is also reported from field observations from the Iranian part of the Zagros fold-and-thrust belt, where folds with different surface traces occur. Decoupling between shallow and deep layers by incompetent lithologies at intermediate depths (e.g. marls, mudstones and evaporites) results in the formation of disharmonic folds. The geometry, size and location of such folds may differ between outcropping and subsurface structures. Decoupling may have a significant impact on hydrocarbon exploration in different parts of the Zagros fold-and-thrust belt due to potential offsets between outcropping and subsurface structures and their associated traps