Head And Heck Mucoepidermoid Carcinoma: Clinicopathologic Study Of 173 Cases

Introduction: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor, however few studies have been reported in Brazilian populations. Aim: To report clinical and pathologic data from 173 head and neck MEC treated in the Treatment and Research Center at Hospital do Câncer A. C. Camargo in São Paulo. Study design: Clinical randomized. Material and Method: From 1953 to 1997, 173 cases of MEC were found in the medical files of the center. Data were obtained from the patients' records and histological review of all cases. Results: The mean age of the patients was 44 years and 93 (53.8%) were men; parotid glands were affected in 61 cases (35.2%) and intraoral minor salivary glands in 75 (43.4%). TNM revealed 50.3% of the cases in stages I and II, and histological grading revealed 45.2%, 18.5% and 36.3% low-grade, intermediate-grade and high-grade tumors, respectively. Surgical treatment was employed in 80.3% of the cases, with neck dissection in 52 cases (30.1%), and radiotherapy in 73 (42.2%). Local recurrence, regional and distant metastases were found in 12.7%, 9.8% and 9.2% of the patients, respectively; 5-year and 10-year overall survival rates were 70% and 60%, respectively. Conclusions: MEC affected mainly the parotid gland and the palate of adults, without gender preference. Half of the cases were diagnosed at initial clinical stages and 64% of the tumors were low or intermediate-grade lesions. Surgery was the treatment of choice and prognosis was good.685679684Ellis, G.L., Auclair, P.L., Gnepp, D.R., Surgical Pathology of the salivary glands (1991) Major Problems in Pathology Series, 25. , Philadelphia: WB Saunders CompanyEllis, G.L., Auclair, P.L., Tumors of the Salivary Glands (1996) Armed Forces Institute of Pathology. Atlas of Tumor Pathology. 3 rd Series, , Fascicle 17. WashingtonAuclair, P.L., Goode, R.K., Ellis, G.L., Mucoepidermoid carcinoma of intraoral salivary glands (1992) Cancer, 69, pp. 2021-2030Cardoso, W.P., Denardin, O.V., Rapoport, A., Araujo, V.C., Carvalho, M.B., Proliferating cell nuclear antigen expression in mucoepidermoid carcinoma of salivary glands (2000) São Paulo Med J, 118, pp. 69-74Goode, R.K., Auclair, P.L., Ellis, G.L., Mucoepidermoid carcinoma of the major salivary glands: Clinical and histopathologic analysis of 234 cases with evaluation of grading criteria (1998) Cancer, 82, pp. 1217-1224Brandwein, M.S., Ivanov, K., Wallace, D.I., Hille, J.J., Wang, B., Fahmy, A., Bodian, C., Mills, S.E., Mucoepidermoid carcinoma: A clinicopathologic study of 80 patients with special reference to histological grading (2001) Am J Surg Pathol, 25, pp. 835-845Evans, H.L., Mucoepidermoid carcinoma of salivary glands: A study of 69 cases with special attention to histologic grading (1984) Am J Clin Pathol, 81, pp. 696-701Nascimento, A.G., Amaral, A.L.P., Prado, L.A.F., Kligerman, J., Silveira, T.R.P., Mucoepidermoid carcinoma of salivary glands: A clinicopathologic study of 46 cases (1986) Head Neck Surg, 8, pp. 409-417Plambeck, K., Friedrich, R.E., Bahlo, M., Bartel-Friedrich, S., Klapdor, R., TNM staging, histopathological grading, and tumor-associated antigens in patients with a history of mucoepidermoid carcinoma of the salivary glands (1999) Anticancer Res, 19, pp. 2397-2404Spiro, R.H., Huvos, A.G., Berk, R., Strong, E.W., Mucoepidermoid carcinoma of salivary gland origin: A clinicopathologic study of 367 cases (1978) Am J Surg, 136, pp. 461-468Chinellato, L.E.M., Marquez, I.M., Fleury, R.N., Quevedo, F.C., Estudos da prevalência dos tumores de origem epitelial de glândulas salivares em Serviços de Anatomia Patológica das cidades de Bauru e Jaú (Estado de São Paulo, Brasil) (1994) Rev Fac Odontol Bauru, 2, pp. 45-51Franzi, A.S., Carvalho, M.B., Carcinoma mucoepidermóide avançado das glândulas salivares (1997) Rev Bras Cancerol, 43, pp. 273-280Kusama, K., Iwanari, S., Aisaki, K., Wada, M., Ohtani, J., Itoi, K., Hanai, K., Moro, I., Intraoral minor salivary gland tumors: A retrospective study of 129 cases (1997) J Nihon Univ Sch Dent, 39, pp. 128-132Lopes, M.A., Kowalski, L.P., Santos, G.C., Almeida, O.P., A clinicopathologic study of 196 intraoral minor salivary gland tumors (1999) J Oral Pathol Med, 28, pp. 264-267Loyola, A.M., De Araujo, V.C., De Sousa, S.O.M., De Araujo, N.S., Minor salivary gland tumours: A retrospective study of 164 cases in a Brazilian population (1995) Oral Oncol Eur J Cancer, 31 B, pp. 197-201Rapoport, A., De Andrade Sobrinho, J., Brasilino De Carvalho, M., Magrin, J., Fava, A.S., Cancer of the parotid gland (1981) Int Surg, 66, pp. 243-246Rapoport, A., Carvalho, M.B., Fava, A.S., Góis Filho, J.F., Chagas, J.F.S., Kowalski, L.P., Kanda, J.L., Cheuhen, J.A., Diagnóstico e tratamento das neoplasias das glândulas salivares menores: Estudo de 55 casos (1988) Rev Col Bras Cirur, 15, pp. 289-293Regis De Brito Santos, I., Kowalski, L.P., Cavalcante De Araujo, V., Flavia Logullo, A., Magrin, J., Multivariate analysis of risk factors for neck metastasis in surgically treated parotid carcinomas (2001) Arch Otolaryngol Head Neck Surg, 127, pp. 56-60Spiro, R.H., Thaler, H.T., Hicks, W.F., Kher, U.A., Huvos, A.H., Strong, E.W., The importance of clinical staging of minor salivary gland carcinoma (1991) Am J Surg, 162, pp. 330-336Hicks, M.J., El-Naggar, A.K., Flaitz, C.M., Luna, M.A., Batsakis, J.G., Histocytologic grading of mucoepidermoid carcinoma of major salivary glands in prognosis and survival: A clinicopathologic and flow cytometric investigation (1995) Head Neck, 17, pp. 89-95Hicks, J., Flaitz, C., Mucoepidermoid carcinoma of salivary glands in children and adolescents: Assessment of proliferation markers (2000) Oral Oncol, 36, pp. 454-460Ma'aita, J.K., Al-Kalsi, N., Al-Tamimi, S., Wraikat, A., Salivary gland tumors in Jordan: A retrospective study of 221 patients (1999) Croat Med J, 40, pp. 539-54

Performance of a fine-sampling electromagnetic calorimeter prototype in the energy range from 1 to 19 GeV

The fine-sampling electromagnetic calorimeter prototype has been experimentally tested using the 1-19 GeV/c tagged beams of negatively charged particles at the U70 accelerator at IHEP, Protvino. The energy resolution measured by electrons is Delta{E}/E=2.8%/\sqrt{E} + 1.3%. The position resolution for electrons is Delta{x}=3.1 + 15.4/sqrt{E} mm in the center of the cell. The lateral non-uniformity of the prototype energy response to electrons and MIPs has turned out to be negligible. Obtained experimental results are in a good agreement with Monte-Carlo simulations.Comment: Article is prepared for pdflatex using the class elsart. 13 pages, 9 figures in 11 PDF file

IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen

Broad optical bandwidth InGaAs-InAlGaAs light-emitting diodes fabricated using a laser annealing process

The use of a laser-induced quantum-well intermixing technique in the InGaAs-InAlGaAs material system is presented. We report blue shifts of up to 240 nm in the 1.55-μm emission wavelength, generated by exposure to a Nd:YAG laser. Variations in the optical intensity across the irradiating beam were used to laterally grade the bandgap along a sample. We used this technique to fabricate broad optical bandwidth, light-emitting diodes. The devices showed an increase in the full width half maximum of the emission spectrum from 125 nm in undisordered devices to over 260 nm in intermixed material. The output spectrum was also observed to be flat-topped (within 5%) across a wavelength range of 140 nm

Post-Growth Bandgap Engineering in InP

We report novel quantum-well intermixing techniques that allow multiple bandgaps to be generated on a single InP substrate or device. The proposed processes are suitable for the manufacture of monolithically integrated optoelectronic devices and circuits

Epithelial Lacrimal Gland Tumors: A Clinicopathological Study Of 18 Cases

OBJECTIVE: The aim of this study was to report the clinicopathological features of 18 epithelial tumors of the lacrimal gland treated in a single institution. STUDY DESIGN AND SETTING: Clinical data and treatment were recorded and histological features reviewed. RESULTS: Twelve tumors (66.7%) were adenoid cystic carcinoma (ACC), 5 (27.8%) pleomorphic adenoma (PA), and 1 (5.5%) carcinoma ex pleomorphic adenoma. All patients with ACC presented with advanced clinical stage, and most were treated by wide surgical resection followed by adjuvant radiotherapy. No recurrence was observed in 4 cases of ACC; however, 7 patients died from persistence of disease or by local and/or distant recurrence. All PA patients were successfully treated by surgical resection. CONCLUSIONS: Epithelial lacrimal gland tumors are mainly PA and ACC, and malignancies are more common than benign tumors. Although ACC presented typically with advanced clinical stage, 33% of the patients survived without tumor recurrence or metastasis. EBM rating: C-4 © 2006 American Academy of Otolaryngology-Head and Neck Surgery Foundation, Inc. All rights reserved.1342321325Shields, J.A., Shields, C.L., Scartozzi, R., Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1 (2004) Ophthalmology, 111, pp. 997-1008Font, R.L., Shannon, L.S., Bryan, R.G., Malignant epithelial tumors of the lacrimal glands. a clinicopathologic study of 21 cases (1998) Arch Ophthalmol, 116, pp. 613-616Paulino, A.F.G., Huvos, A.G., Epithelial tumors of the lacrimal glands: A clinicopathologic study (1999) Ann Diagn Pathol, 3, pp. 199-204Chuo, N., Ping-Kuan, K., Dryja, T.P., Histopathological classification of 272 primary epithelial tumors of the lacrimal gland (1992) Chin Med J, 6, pp. 481-485McLean, I.W., Burnier, M.N., Zimmerman, L.E., (1994) Atlas of Tumor Pathology: Tumors of the Eye and Ocular Adnexa, pp. 215-232. , AFIP Washington, DCEsmaeli, B., Ahmadi, M.A., Youssef, A., Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland (2004) Ophthal Plast Reconstr Surg, 20, pp. 22-26Sobin, L.H., Ch, W., (2002) UICC TNM Classification of Malignant Tumors, p. 272. , 6th ed. John Wiley & Sons, Inc New YorkVangveeravong, S., Katz, S.E., Rootman, J., Tumors arising in the palpebral lobe of the lacrimal gland (1996) Ophthalmology, 103, pp. 1606-1612Shields, C.L., Shields, J.A., Review of lacrimal gland lesions (1990) Trans Pa Acad Ophthalmol Otolaryngol, 42, pp. 925-930Wright, J.E., Rose, G.E., Garner, A., Primary malignant neoplasms of the lacrimal gland (1992) Br J Ophthalmol, 76, pp. 401-407Font, R.L., Gamel, J.W., Epithelial tumors of the lacrimal gland: An analysis of 265 cases (1978) Ocular and Adnexal Tumors, pp. 787-805. , F.A. Jakobiec Aescolapius Publishers Inc New York, NYCates, C.A., Manners, R.M., Rose, G.E., Pleomorphic adenoma of the lacrimal gland in a 10-year-old girl (2002) Br J Ophthalmol, 86, pp. 249-250Breceli, J., Stim-Kranjc, B., Skrbec, M., Visual electrophysiology in children with tumors affecting the visual pathway. Case reports (2000) Doc Ophthalmol, 101, pp. 125-154Faktorovich, E.G., Crawford, J.B., Char, D.H., Benign mixed tumor (pleomorphic adenoma) of the lacrimal gland in a 6-year-old boy (1996) Am J Ophthalmol, 122, pp. 446-447Chandrasekhar, J., Farr, D.R., Whear, N.M., Pleomorphic adenoma of the lacrimal gland: Case report (2001) Br J Oral Maxillofac Surg, 39, pp. 390-393Sturgis, C.D., Silverman, J.F., Kennerdell, J.S., Fine-needle aspiration for the diagnosis of primary epithelial tumors of the lacrimal gland and ocular adnexa (2001) Diagn Cytopathol, 24, pp. 86-89Perzin, K.H., Jakobiec, F.A., Livolsi, V.A., Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): A clinico-pathologic study (1980) Cancer, 45, pp. 2593-2606Ostrowski, M.L., Font, R.L., Halpern, J., Clear cell epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland (1994) Ophthalmology, 101, pp. 925-930Friedrich, R.E., Bleckmann, V., Adenoid cystic carcinoma of salivary and lacrimal gland origin: Localization, classification, clinical pathological correlation, treatment results and long-term follow-up control in 84 patients (2003) Anticancer Res, 23, pp. 931-940Polito, E., Leccisotti, A., Epithelial malignancies of the lacrimal gland: Survival rates after extensive and conservative therapy (1993) Ann Ophthalmol, 25, pp. 422-426Meldrum, M.L., Tse, D.T., Benedetto, P., Neoadjuvant intracarotid CT for the treatment of advanced adenocystic carcinoma of the lacrimal gland (1998) Arch Ophthalmol, 116, pp. 315-321Gamel, J.W., Font, R.L., Adenoid cystic carcinoma of the lacrimal gland: The clinical significance of a basaloid histologic pattern (1982) Hum Pathol, 13, pp. 219-22

High Performance Visible Semiconductor Lasers Operating at 630 nm

630 nm single mode lasers with a V-profile layer incorporated within the waveguide core exhibit reduced fast axis divergence (19° FWHM) while maintaining a low threshold current (30 mA), making them ideal for display applications

Sublingual Salivary Gland Tumors: Clinicopathologic Study Of Six Cases.

OBJECTIVE: The aim of this study was to assess the clinical and histologic features of 6 cases of sublingual salivary gland tumors treated in a single institution. STUDY DESIGN: The clinical data were obtained from the medical records, and the histopathologic slides were reviewed. RESULTS: Four cases were adenoid cystic carcinoma (ACC) and 2 were mucoepidermoid carcinoma (MEC). Most cases were clinically staged as T3N0M0. Histologically, 3 cases of ACC were of the cribriform subtype and 1 was tubular. One MEC was classified as intermediate and 1 as high grade of malignancy. After surgical treatment, 3 patients (2 MEC and 1 ACC) did not show tumoral recurrence after a mean time of 162 months of follow-up (ranging from 120 to 216 months). CONCLUSIONS: Sublingual salivary gland tumors are very rare and most are malignant; in our series, 3 cases of ACC had poor prognosis but the patients with MEC were considered cured of the disease.100444945

GaAs/AlGaAs waveguide pin photodiodes with non-absorbing input facets fabricated by quantum well intermixing

Waveguide photodiodes with non-absorbing input windows have been fabricated using a sputtered silica quantum well intermixing technique. Thermal modelling of the GaAs/AlGaAs photodiodes indicates that facet temperatures can be significantly reduced with window lengths of greater than 10 /spl mu/m. Device testing shows that optical damage occurs at double the power of conventional photodiodes with absorbing facets

Extended cavity ridge waveguide lasers operating at 1.5 [micro sign]m using a simple damage induced quantum well intermixing process

The authors report extended cavity ridge waveguide lasers in InGaAs-InGaAsP, intermixed by damage induced via a silica sputtering process, with selective intermixing achieved through photoresist masking. Laser threshold currents indicate passive waveguide losses of 4.4 cm/sup -1/