Survival analysis of culling reasons and economic examination of production period in sow culling

The culling of the sows is an important task of the breeders and farmers, besides it is a determining factor of profitable pork production. During our research we have surveyed the data of 1969 sows in a Hungarian large-scale pig farm. For the calculation of our results we used one of the non-parametric forms of survival analysis, the Kaplan-Meier analysis. For the quantification of death intensity we applied another survival analysis model, the log-rate exponential model. We have found out the risk values of various culling reasons form the point of view of culling. Besides, we tried to quantify by an economic model how the production period of sows influences the average costs of piglets and the average costs of piglets per kilo at 2006 prices. We calculated that the 5th farrowing is the minimum cost place.Sow culling, Risk analysis, Sow productivity, Average costs of piglets, Livestock Production/Industries,

Dirac eigenmodes at the QCD Anderson transition

Recently we found an Anderson-type localization-delocalization transition in the QCD Dirac spectrum at high temperature. Using spectral statistics we obtained a critical exponent compatible with that of the corresponding Anderson model. Here we study the spatial structure of the eigenmodes both in the localized and the transition region. Based on previous studies in the Anderson model, at the critical point, the eigenmodes are expected to have a scale invariant multifractal structure. We verify the scale invariance of Dirac eigenmodes at the critical point.Comment: to appear in Proceedings of The 32nd International Symposium on Lattice Field Theory, 23-28 June, 2014, Columbia University New York, N

Rectus sheath haematoma following exercise testing: a case report

<p>Abstract</p> <p>Introduction</p> <p>Exercise testing is a safe diagnostic procedure which is widely used in the evaluation of patients suspected of having coronary heart disease or for the assessment of the prognosis in patients with established disease. Its complications are mainly cardiac disorders. Here, we report a rectus sheath haematoma as a complication of this procedure in a patient with acute coronary syndrome. To our knowledge, this is the first case report of rectus sheath haematoma in association with exercise testing.</p> <p>Case presentation</p> <p>A 72-year-old Caucasian woman was admitted for acute coronary syndrome. She received conservative treatment including low molecular weight heparin and anti-platelet agents. On the fifth day of her hospital stay, she underwent an exercise test, where no ischaemic response occurred. Several hours later, she experienced pain in the left side of her abdomen. Subsequent investigations revealed a rectus sheath haematoma. The patient underwent surgical haematoma evacuation. A few days later, re-operation was performed for recurrent bleeding in the abdominal wall. The patient had several characteristics known to increase the risk of bleeding during treatment for acute coronary syndrome.</p> <p>Conclusion</p> <p>Awareness of this possible consequence of exercise testing is important for preventing and treating it correctly. For prevention, an assessment of the bleeding risk of the individual patient is necessary before the test, and excessive anticoagulation must be avoided.</p

Fuzzy Automaton as a Detection Mechanism for the Multi-Step Attack

The integration of a fuzzy system and automaton theory can form the concept of fuzzy automaton. This integration allows a discretely defined state-machine to act on continuous universes and handle uncertainty in applications like Intrusion Detection Systems (IDS). The typical IDS detection mechanisms are targeted to detect and prevent single-stage attacks. These types of attacks can be detected using either a common convincing threshold or by pre-defined rules. However, attack techniques have changed in recent years. Currently, the largest proportion of attacks performed, are multi-step attacks. The goal of this paper is to introduce a novel detection mechanism for multi-step attacks built upon Fuzzy Rule Interpolation (FRI) based fuzzy automaton. In that respect, the FRI method instruments the fuzzy automaton to be able to act on a not fully defined state transition rule-base, by offering interpolated conclusion even for situations which are not explicitly defined. In the suggested model, the intrusion definition state transition rule-base is defined using an open source fuzzy declarative language. On the multi-step attack benchmark dataset introduced in this paper, the proposed detection mechanism was able to achieve 97.836% detection rate.  Furthermore, in the studied examples, the suggested method was able not only to detect but also early detect the multi-step attack in stages, where the planned attack is not fully elaborated and hence less harmful. According to these results, the IDS built upon the FRI based fuzzy automaton could be a useful device for detecting multi-step attacks, even in cases when the intrusion state transition rule-based is incomplete. The early detection of multi-step attacks also allows the administrator to take the necessary actions in time, to mitigate the potential threats

Hőkezelési Döntéstámogató Rendszer bevezetése az ISD Dunaferrnél

Az acélok edzési technológiájának tervezésére numerikus szimulációs rendszer kifejlesztésére és bevezetésére került sor az ISD Dunaferrnél. A Hõkezelési Döntéstámogató Rendszer az edzett munkadarabok elvárt tulajdonságegyüttesének kialakításához szükséges hõkezelési paraméterek kiválasztásához nyújt segítséget. A rendszer alkalmazhatóságát egy esettanulmányon keresztül mutatjuk b

Investigation of the Antiremodeling Effects of Losartan, Mirabegron and Their Combination on the Development of Doxorubicin-Induced Chronic Cardiotoxicity in a Rat Model

Despite the effectiveness of doxorubicin (DOXO) as a chemotherapeutic agent, dose-dependent development of chronic cardiotoxicity limits its application. The angiotensin-II receptor blocker losartan is commonly used to treat cardiac remodeling of various etiologies. The beta-3 adrenergic receptor agonist mirabegron was reported to improve chronic heart failure. Here we investigated the effects of losartan, mirabegron and their combination on the development of DOXO-induced chronic cardiotoxicity. Male Wistar rats were divided into five groups: (i) control; (ii) DOXO-only; (iii) losartan-treated DOXO; (iv) mirabegron-treated DOXO; (v) losartan plus mirabegron-treated DOXO groups. The treatments started 5 weeks after DOXO administration. At week 8, echocardiography was performed. At week 9, left ventricles were prepared for histology, qRT-PCR, and Western blot measurements. Losartan improved diastolic but not systolic dysfunction and ameliorated SERCA2a repression in our DOXO-induced cardiotoxicity model. The DOXO-induced overexpression of Il1 and Il6 was markedly decreased by losartan and mirabegron. Mirabegron and the combination treatment improved systolic and diastolic dysfunction and significantly decreased overexpression of Smad2 and Smad3 in our DOXO-induced cardiotoxicity model. Only mirabegron reduced DOXO-induced cardiac fibrosis significantly. Mirabegron and its combination with losartan seem to be promising therapeutic tools against DOXO-induced chronic cardiotoxicity.Peer reviewe

Investigation of the Antihypertrophic and Antifibrotic Effects of Losartan in a Rat Model of Radiation-Induced Heart Disease

Radiation-induced heart disease (RIHD) is a potential late side-effect of thoracic radiotherapy resulting in left ventricular hypertrophy (LVH) and fibrosis due to a complex pathomechanism leading to heart failure. Angiotensin-II receptor blockers (ARBs), including losartan, are frequently used to control heart failure of various etiologies. Preclinical evidence is lacking on the anti-remodeling effects of ARBs in RIHD, while the results of clinical studies are controversial. We aimed at investigating the effects of losartan in a rat model of RIHD. Male Sprague-Dawley rats were studied in three groups: (1) control, (2) radiotherapy (RT) only, (3) RT treated with losartan (per os 10 mg/kg/day), and were followed for 1, 3, or 15 weeks. At 15 weeks post-irradiation, losartan alleviated the echocardiographic and histological signs of LVH and fibrosis and reduced the overexpression of chymase, connective tissue growth factor, and transforming growth factor-beta in the myocardium measured by qPCR; likewise, the level of the SMAD2/3 protein determined by Western blot decreased. In both RT groups, the pro-survival phospho-AKT/AKT and the phospho-ERK1,2/ERK1,2 ratios were increased at week 15. The antiremodeling effects of losartan seem to be associated with the repression of chymase and several elements of the TGF-beta/SMAD signaling pathway in our RIHD model.Peer reviewe

Comparison of the antiremodeling effects of losartan and mirabegron in a rat model of uremic cardiomyopathy

Uremic cardiomyopathy is characterized by diastolic dysfunction (DD), left ventricular hypertrophy (LVH), and fibrosis. Angiotensin-II plays a major role in the development of uremic cardiomyopathy via nitro-oxidative and inflammatory mechanisms. In heart failure, the beta-3 adrenergic receptor (beta 3-AR) is up-regulated and coupled to endothelial nitric oxide synthase (eNOS)-mediated pathways, exerting antiremodeling effects. We aimed to compare the antiremodeling effects of the angiotensin-II receptor blocker losartan and the beta 3-AR agonist mirabegron in uremic cardiomyopathy. Chronic kidney disease (CKD) was induced by 5/6th nephrectomy in male Wistar rats. Five weeks later, rats were randomized into four groups: (1) sham-operated, (2) CKD, (3) losartan-treated (10 mg/kg/day) CKD, and (4) mirabegron-treated (10 mg/kg/day) CKD groups. At week 13, echocardiographic, histologic, laboratory, qRT-PCR, and Western blot measurements proved the development of uremic cardiomyopathy with DD, LVH, fibrosis, inflammation, and reduced eNOS levels, which were significantly ameliorated by losartan. However, mirabegron showed a tendency to decrease DD and fibrosis; but eNOS expression remained reduced. In uremic cardiomyopathy, beta 3-AR, sarcoplasmic reticulum ATPase (SERCA), and phospholamban levels did not change irrespective of treatments. Mirabegron reduced the angiotensin-II receptor 1 expression in uremic cardiomyopathy that might explain its mild antiremodeling effects despite the unchanged expression of the beta 3-AR.Peer reviewe

Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells

Exosomes are small extracellular vesicles (sEVs), playing a crucial role in the intercellular communication in physiological as well as pathological processes. Here, we aimed to study whether the melanoma-derived sEV-mediated communication could adapt to microenvironmental stresses. We compared B16F1 cell-derived sEVs released under normal and stress conditions, including cytostatic, heat and oxidative stress. The miRNome and proteome showed substantial differences across the sEV groups and bioinformatics analysis of the obtained data by the Ingenuity Pathway Analysis also revealed significant functional differences. The in silico predicted functional alterations of sEVs were validated by in vitro assays. For instance, melanoma-derived sEVs elicited by oxidative stress increased Ki-67 expression of mesenchymal stem cells (MSCs); cytostatic stress-resulted sEVs facilitated melanoma cell migration; all sEV groups supported microtissue generation of MSC-B16F1 co-cultures in a 3D tumour matrix model. Based on this study, we concluded that (i) molecular patterns of tumour-derived sEVs, dictated by the microenvironmental conditions, resulted in specific response patterns in the recipient cells; (ii) in silico analyses could be useful tools to predict different stress responses; (iii) alteration of the sEV-mediated communication of tumour cells might be a therapy-induced host response, with a potential influence on treatment efficacy.Peer reviewe