510 research outputs found
Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators
Strain and dynamic measurements using fiber optic sensors embedded into graphite/epoxy tubes
Graphite/epoxy tubes were fabricated with embedded optical fibers to evaluate the feasibility of monitoring strains with a fiber optic technique. Resistance strain gauges were attached to the tubes to measure strain at four locations along the tube for comparison with the fiber optic sensors. Both static and dynamic strain measurements were made with excellent agreement between the embedded fiber optic strain sensor and the strain gauges. Strain measurements of 10(exp -7) can be detected with the optical phase locked loop (OPLL) system using optical fiber. Because of their light weight, compatibility with composites, immunity to electromagnetic interference, and based on the static and dynamic results obtained, fiber optic sensors embedded in composites may be useful as the sensing component of smart structures
Electronic Performance Support Systems: An Assistive Technology Tool for Secondary Students with Mild Disabilities
Further information may be found at http://kidtools.missouri.edu/AboutKTSSPrograms.phpThis article presents the results of a qualitative study investigating the usability and perceived effectiveness
of StrategyToolsâ„¢, an electronic performance system support designed for secondary students with mild disabilities to use independently in classroom and home situations. The StrategyTools software contains 39 computerized research-based strategy tools to support learning, behavior, and transition in high school and
beyond
Integration of Augmented Reality and Neuromuscular Control Systems for Remote Vehicle Operations
Traditional remotely operated vehicles (ROV’s) require extensive setup and unnatural control systems. Integrating wearable devices as a control system, operators gain mobility and situational awareness to execute additional tasks. Analysis is conducted to understand if wearable devices connected by Internet of Things (IoT) allows for a more natural control system. A gesture recognition armband is worn around the operator’s forearm reading surface electromyography (sEMG) signals produced by their muscles to recognize hand gestures. An Augmented Reality (AR) headset overlays supplemental information on a heads-up display (HUD). IoT enables each component of the system to transmit and receive data over a network. The AR headset serves as the central processing unit, processing sEMG signals and transmitting respective commands to a ROV. The ROV acts on the received commands and transmits data, describing its actions and environment, to be displayed. A library of electrical signals that relate to hand gestures defined in US Army Publication TC3-21.60 are developed as a control set of commands. Signal processing and machine learning methods are implemented to reduce cross-talk and interference of weak sEMG signals for accurate gesture recognition. Results provide insight on the effectiveness of neuromuscular control compared to human-to-human instruction, and how wearable control systems can increase operator situational awareness
Estimativas de parâmetros genéticos para escores visuais de conformação, precocidade e musculatura e suas relações com peso à desmama em bovinos da raça Nelore.
Estimativas de herdabilidade e correlações para escores visuais, peso e altura ao sobreano em rebanhos da raça Nelore.
Os objetivos neste trabalho foram avaliar as relações entre os escores visuais de estrutura corporal, precocidade e musculosidade ao sobreano (aproximadamente 550 dias de idade) com caracterÃsticas de crescimento para verificar as possibilidades de utilizar essas caracterÃsticas como critérios de seleção. Foram obtidas estimativas dos componentes de covariâncias por máxima verossimilhança restrita empregando-se um modelo animal com o efeito fixo de grupo contemporâneo e a idade como covariável (efeitos linear e quadrático). Os grupos contemporâneos foram definidos pelas variáveis: sexo; ano, estação e fazenda de nascimento; e fazenda e grupo de manejo aos 120, 210, 365 e 550 dias de idade. Foram utilizadas 1.367 observações de estrutura corporal, precocidade e musculosidade. As estimativas de herdabilidade foram de 0,24 ± 0,09 para estrutura corporal; 0,63 ± 0,12 para precocidade e 0,48 ± 0,11 para musculosidade, e as estimativas de correlações genéticas entre os escores foram 0,49 entre estrutura corporal e precocidade; 0,63 entre estrutura corporal e musculosidade; e 0,90 entre precocidade e musculosidade. As correlações genéticas entre os escores de estrutura corporal, precocidade e musculosidade, e o peso ao sobreano foram todas positivas (0,83; 0,42 e 0,50, respectivamente), enquanto as estimativas de correlações genéticas entre altura de posterior e os escores de estrutura corporal, precocidade e musculosidade, respectivamente, foram 0,57, -0,29 e -0,33. As caracterÃsticas estrutura corporal, precocidade e musculosidade ao sobreano apresentaram variação genética aditiva de moderada a alta. As correlações genéticas dos escores com altura do posterior indicam que a seleção de animais mais altos, ainda que indireta, pode ocasionar aumento da estrutura corporal média dos animais, que poderão ser menos precoces e menos musculosos ao sobreano. A seleção para os escores visuais, principalmente para estrutura corporal, deve promover aumento no peso ao sobreano dos animais.Meta de 2010
Desempenho de reprodutores jovens da Raça Nelore em teste de performance a pasto no Acre.
O objetivo deste trabalho foi avaliar a eficiência do teste de performance a pasto da raça Nelore no Acre e do Ãndice de seleção utilizado em discriminar grupos de tourinhos geneticamente superiores a serem adotados para melhoria dos indicadores de eficiência e rentabilidade dos sistemas de produção de carne tradicionais do estado.bitstream/item/209142/1/26944.pd
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Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial
Peginterferon plus ribavirin achieves sustained virological response (SVR) in fewer than half of patients with genotype 1 chronic hepatitis C virus infection treated for 48 weeks. We tested the efficacy of boceprevir, an NS3 hepatitis C virus oral protease inhibitor, when added to peginterferon alfa-2b and ribavirin.
In part 1 of this trial, undertaken in 67 sites in the USA, Canada, and Europe, 520 treatment-naive patients with genotype 1 hepatitis C virus infection were randomly assigned to receive peginterferon alfa-2b 1·5 μg/kg plus ribavirin 800–1400 mg daily for 48 weeks (PR48; n=104); peginterferon alfa-2b and ribavirin daily for 4 weeks, followed by peginterferon alfa-2b, ribavirin, and boceprevir 800 mg three times a day for 24 weeks (PR4/PRB24; n=103) or 44 weeks (PR4/PRB44; n=103); or peginterferon alfa-2b, ribavirin, and boceprevir three times a day for 28 weeks (PRB28; n=107) or 48 weeks (PRB48; n=103). In part 2, 75 patients were randomly assigned to receive either PRB48 (n=16) or low-dose ribavirin (400–1000 mg) plus peginterferon alfa-2b and boceprevir three times a day for 48 weeks (low-dose PRB48; n=59). Randomisation was by computer-generated code, and study personnel and patients were not masked to group assignment. The primary endpoint was SVR 24 weeks after treatment. Analysis was by intention to treat. This study is registered with
ClinicalTrials.gov, number
NCT00423670.
Patients in all four boceprevir groups had higher rates of SVR than did the control group (58/107 [54%, 95% CI 44–64], p=0·013 for PRB28; 58/103 [56%, 44–66], p=0·005 for PR4/PRB24; 69/103 [67%, 57–76], p<0·0001 for PRB48; and 77/103 [75%, 65–83], p<0·0001 for PR4/PRB44;
vs 39/104 [38%, 28–48] for PR48 control). Low-dose ribavirin was associated with a high rate of viral breakthrough (16/59 [27%]), and a rate of relapse (six of 27 [22%]) similar to control (12/51 [24%]). Boceprevir-based groups had higher rates of anaemia (227/416 [55%]
vs 35/104 [34%]) and dysgeusia (111/416 [27%]
vs nine of 104 [9%]) than did the control group.
In patients with untreated genotype 1 chronic hepatitis C infection, the addition of the direct-acting antiviral agent boceprevir to standard treatment with peginterferon and ribavirin after a 4-week lead-in seems to have the potential to double the sustained response rate compared with that recorded with standard treatment alone.
Merck
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