Physicochemical characterization, kinetic parameters, shelf life and its prediction models of virgin olive oil from two cultivars (“Arbequina” and “Moroccan Picholine”) grown in Morocco

This works aimed at investigating shelf-life behavior of extra virgin olive oil (EVOO) extracted from two cultivars “Arbequina” and “Moroccan Picholine” as a function of storage time (8 weeks) at accelerated conditions (60 °C). Our outcomes revealed significant variations between EVOOs from both cultivars in terms of the investigated physicochemical characteristics. These were also affected by storage time and temperature except for fatty acids, for which storage time had no significant effects. While the changes in tocopherols showed a drastic reduction ranging from 48.18 (“Moroccan Picholine”) to 62.62% (“Arbequina”). Indeed, the changes of quality indices showed a linear increase. Moreover, “Arbequina” oil was the first to exceed the established upper limits for EVOO label. An increase in oxidation rate was observed with increasing temperature when oils were oxidized at six elevated temperatures (373, 383, 393, 403, 413 and 423 °K) under Rancimat test conditions. The natural logarithms of the kinetic rate constant varied linearly with respect to temperature, with temperature coefficient (TCoeff) ranging from 7.31 × 10−2 in “Arbequina” to 7.51 × 10−2 K−1 found in “Moroccan Picholine”. This had higher oxidative stability and shelf life as compared to “Arbequina”. These outcomes were confirmed by kinetic parameters of oxidative stability including reaction rate constant as well as Arrhenius equation and thermodynamic parameters

Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions

A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale). A comparison of common green metrics to current routes showed clear improvements, with at least a one order of magnitude increase in space-time-yield

Développement et application des réactions d'arylations et d'alcénylations directes pallado-catalysées pour la synthèse d'imidazo[1,2-a]pyridines diversement substituées

Notre objectif principal réside dans la mise au point d une méthode de synthèse permettant d accéder d une façon rapide, efficace et économique à différents dérivés imidazo[1,2-a]pyridiniques diversement fonctionnalisés.Pour ce faire, l étude et l application des réactions d (hétéro)arylation et d alcénylation directes catalysées par le palladium sur les imidazo[1,2-a]pyridines ont été explorées et ce, en chauffage classique ou sous irradiation micro-ondes. Nous avons ensuite montré l intérêt de la réaction d arylation régiosélective pour synthétiser des molécules imidazo[1,2-a]pyridiniques polysubstituées, via une réaction "one-pot" sous irradiation micro-ondes.Afin de réduire davantage le nombre d étapes, nous avons élaboré une réaction d acénylation oxydative pallado-catalysée, pour la formation de la liaison carbone sp2 - carbone sp2 à partir de deux liaisons carbone sp2 - hydrogène.La dernière partie de ce travail repose sur le développement et l application de la réaction d arylation intramoléculaire pour la synthèse de nouvelles pyrido[2 ,1 :2,3]imidazo[5,4-c]quinolin-6(5H)-ones et pyrido[2 ,1 :2,3]imidazo[5,4-c]azépin-6(5H)-ones polyfonctionnalisées.ORLEANS-BU Sciences (452342104) / SudocSudocFranceF