Experimental study on the influence of pore structure on spontaneous imbibition in marine black shale

Recently, significant progress has been made in the exploration of marine shale gas in the Qiongzhusi Formation of the Sichuan Basin, China. Micro/nanopores within this formation play a crucial role in spontaneous imbibition and subsequent shale gas production. In this paper, to investigate the influence of pore structure in the Qiongzhusi shale on the spontaneous imbibition characteristics, two sets of samples with varying mineral contents were subjected to horizontal and vertical spontaneous imbibition experiments. Onedimensional transverse relaxation time, two-dimensional longitudinal-transverse relaxation time, and layer division transverse relaxation time spectra from low-field nuclear magnetic resonance were analyzed to elucidate fluid migration during spontaneous imbibition as well as contributions from different pore sizes toward the overall imbibition capacity. The results indicated that, among different pore sizes, mesopores have the greatest impact on the imbibition rate of marine carbonaceous shale, followed by micropores and macropores. The organic matter and clay minerals in carbonaceous shale were found to play a significant role in enhancing the permeability and absorption rate by the presence of abundant mesopores. Besides, the bedding development of marine carbonaceous shale in the Qiongzhusi Formation influences the imbibition process. The horizontal samples exhibited lower levels of imbibition efficiency than their vertical counterparts.Document Type: Original articleCited as: Fu, C., Xu, X., Du, Y., Kou, X. Experimental study on the influence of pore structure on spontaneous imbibition in marine black shale. Capillarity, 2024, 10(3): 57-72. https://doi.org/10.46690/capi.2024.03.0

Real-time particle dispersion from a DPI using image velocimetry – Evaluation of powder adhesion, impact, and collision

Dry powder inhaler (DPI) is a dosage form for delivering fine drug powders to the respiratory tract. Particle size and size distribution, proportion of fines, particle shape, particle surface roughness, flow rate and adhesion force have been reported to affect the aerosolization process. Several mechanisms for particle dispersion in DPI have been considered; a proposed mechanism to explain the particle dispersion phenomenon is the active site theory. However, there have been several conflicting reports, therefore, an agglomeration/fracture hypothesis has been also proposed. Particle dispersion is associated with events such as impact, acceleration, shear stress, and turbulent flow. The aim of this study is to use high-speed video imaging to provide direct experimental observation of the particle dispersion process in order to unveil a mechanism for particle dispersion. Mixture of micronized lactose and coarse lactose carrier was placed in a model inhaler device, a high speed video imaging was used to capture the dry powder inhalation process. The flow pattern was found to be turbulent. Particles were observed to collide with one another, causing detachment of micronized particles from the surfaces of the coarse lactose particles. Impact of the powder agglomerates on the device grid also contributed to deaggregation and dispersion of the particles. The findings suggest that collision and impact are important mechanisms for the dispersion of DPI particles

Sleep duration and patterns in Chinese older adults: A comprehensive meta-analysis

This meta-analysis examined the mean sleep duration and patterns in Chinese older adult population. A literature search was systematically conducted covering major English (PubMed, Embase and PsycINFO) and Chinese (Chinese National Knowledge Infrastructure (CNKI), WanFang and SinoMed) databases. Data in studies with the mean and standard deviation of sleep duration and/or the proportion of short and long sleep durations in Chinese older adults were extracted and pooled using random-effects models. Subgroup analyses were conducted according to gender, region, area, survey time and sample size. A total of 36 studies with 150,616 subjects were included for analyses. The pooled mean sleep duration of 21 studies with available data was 6.82 hours/day (95% CI: 6.59–7.05 hours/day). The estimated proportions of sleep duration \u3c5 hours/day, \u3c6 hours/day, \u3c7 hours/day were 18.8% (95% CI: 1.7%–35.9%), 26.7% (95% CI: 19.7%–33.7%) and 42.3% (95% CI: 34.8%–49.8%), respectively. The pooled proportions for long sleepers were 22.6% (95% CI: 13.9%–31.4%) (\u3e8 hours/day) and 17.6% (95% CI: 12.4%–22.9%) (\u3e9 hours/day). Given the adverse effects of unhealthy sleep patterns, health professionals should pay more attention to sleep patterns in this population in China

Faster Ray Tracing through Hierarchy Cut Code

We propose a novel ray reordering technique to accelerate the ray tracing process by encoding and sorting rays prior to traversal. Instead of spatial coordinates, our method encodes rays according to the cuts of the hierarchical acceleration structure, which is called the hierarchy cut code. This approach can better adapt to the acceleration structure and obtain a more reliable encoding result. We also propose a compression scheme to decrease the sorting overhead by a shorter sorting key. In addition, based on the phenomenon of boundary drift, we theoretically explain the reason why existing reordering methods cannot achieve better performance by using longer sorting keys. The experiment demonstrates that our method can accelerate secondary ray tracing by up to 1.81 times, outperforming the existing methods. Such result proves the effectiveness of hierarchy cut code, and indicate that the reordering technique can achieve greater performance improvement, which worth further research

Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair

Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair (PIR). We and others proposed that PIR hijacks the host cell double-strand DNA break (DSB) repair pathways. Nevertheless, the geometry of retroviral DNA integration differs considerably from that of DSB repair and so the precise role of host-cell mechanisms in PIR remains unclear. In the current study, we found that the Nijmegen breakage syndrome 1 protein (NBS1), an early sensor of DSBs, associates with HIV-1 DNA, recruits the ataxia telangiectasia-mutated (ATM) kinase, promotes stable retroviral transduction, mediates efficient integration of viral DNA and blocks integrase-dependent apoptosis that can arise from unrepaired viral-host DNA linkages. Moreover, we demonstrate that the ATM kinase, recruited by NBS1, is itself required for efficient retroviral transduction. Surprisingly, recruitment of the ATR kinase, which in the context of DSB requires both NBS1 and ATM, proceeds independently of these two proteins. A model is proposed emphasizing similarities and differences between PIR and DSB repair. Differences between the pathways may eventually allow strategies to block PIR while still allowing DSB repair

Retinal image synthesis from multiple-landmarks input with generative adversarial networks

Background Medical datasets, especially medical images, are often imbalanced due to the different incidences of various diseases. To address this problem, many methods have been proposed to synthesize medical images using generative adversarial networks (GANs) to enlarge training datasets for facilitating medical image analysis. For instance, conventional methods such as image-to-image translation techniques are used to synthesize fundus images with their respective vessel trees in the field of fundus image. Methods In order to improve the image quality and details of the synthetic images, three key aspects of the pipeline are mainly elaborated: the input mask, architecture of GANs, and the resolution of paired images. We propose a new preprocessing pipeline named multiple-channels-multiple-landmarks (MCML), aiming to synthesize color fundus images from a combination of vessel tree, optic disc, and optic cup images. We compared both single vessel mask input and MCML mask input on two public fundus image datasets (DRIVE and DRISHTI-GS) with different kinds of Pix2pix and Cycle-GAN architectures. A new Pix2pix structure with ResU-net generator is also designed, which has been compared with the other models. Results and conclusion As shown in the results, the proposed MCML method outperforms the single vessel-based methods for each architecture of GANs. Furthermore, we find that our Pix2pix model with ResU-net generator achieves superior PSNR and SSIM performance than the other GANs. High-resolution paired images are also beneficial for improving the performance of each GAN in this work. Finally, a Pix2pix network with ResU-net generator using MCML and high-resolution paired images are able to generate good and realistic fundus images in this work, indicating that our MCML method has great potential in the field of glaucoma computer-aided diagnosis based on fundus image

Differential Responses of MET Activations to MET kinase Inhibitor and Neutralizing Antibody

Background: Aberrant MET tyrosine kinase signaling is known to cause cancer initiation and progression. While MET inhibitors are in clinical trials against several cancer types, the clinical efficacies are controversial and the molecular mechanisms toward sensitivity remain elusive. Methods: With the goal to investigate the molecular basis of MET amplification (MET amp ) and hepatocyte growth factor (HGF) autocrine-driven tumors in response to MET tyrosine kinase inhibitors (TKI) and neutralizing antibodies, we compared cancer cells harboring MET amp (MKN45 and MHCCH97H) or HGF-autocrine (JHH5 and U87) for their sensitivity and downstream biological responses to a MET-TKI (INC280) and an anti-MET monoclonal antibody (MetMab) in vitro, and for tumor inhibition in vivo. Results: We find that cancer cells driven by MET amp are more sensitive to INC280 than are those driven by HGF-autocrine activation. In MET amp cells, INC280 induced a DNA damage response with activation of repair through the p53BP1/ATM signaling pathway. Although MetMab failed to inhibit MET amp cell proliferation and tumor growth, both INC280 and MetMab reduced HGF-autocrine tumor growth. In addition, we also show that HGF stimulation promoted human HUVEC cell tube formation via the Src pathway, which was inhibited by either INC280 or MetMab. These observations suggest that in HGF-autocrine tumors, the endothelial cells are the secondary targets MET inhibitors. Conclusions: Our results demonstrate that MET amp and HGF-autocrine activation favor different molecular mechanisms. While combining MET TKIs and ATM inhibitors may enhance the efficacy for treating tumors harboring MET amp , a combined inhibition of MET and angiogenesis pathways may improve the therapeutic efficacy against HGF-autocrine tumors

An Exposome Atlas of Serum Reveals the Risk of Chronic Diseases in the Chinese Population

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, and some of them exceed safe ranges. Multi-exposure models reveal significant risk effects of exposure on hyperlipidemia, metabolic syndrome and hyperuricemia. Overall, this study provides a comprehensive human serum exposome atlas and disease risk information, which can guide subsequent in-depth cause-and-effect studies between environmental exposures and human health

High energy pseudogap and its evolution with doping in Fe-based superconductors as revealed by optical spectroscopy

We report optical spectroscopic measurements on electron- and hole-doped BaFe2As2. We show that the compounds in the normal state are not simple metals. The optical conductivity spectra contain, in addition to the free carrier response at low frequency, a temperature-dependent gap-like suppression at rather high energy scale near 0.6 eV. This suppression evolves with the As-Fe-As bond angle induced by electron- or hole-doping. Furthermore, the feature becomes much weaker in the Fe-chalcogenide compounds. We elaborate that the feature is caused by the strong Hund's rule coupling effect between the itinerant electrons and localized electron moment arising from the multiple Fe 3d orbitals. Our experiments demonstrate the coexistence of itinerant and localized electrons in iron-based compounds, which would then lead to a more comprehensive picture about the metallic magnetism in the materials.Comment: 6 pages, 7 figure