Prosthetic joint infection, dental treatment and antibiotic prophylaxis

Current international and national prophylactic antibiotic regimens have been analyzed in respect of the prevention of bacteremia after dental and surgical procedures and, therefore, of joint prosthesis infection. This information was used to formulate guidelines for the Department of Maxillofacial and Oral Surgery. Publications since 2003 were used in this research. In addition, recommendations of accredited institutions and associations were examined. These included the guidelines of the American Dental Association in association with the American Academy of Orthopaedic Surgeons (2003), the American Heart Association (2007), the Working Party of the British Society for Antimicrobial Chemotherapy (2006) and the Australian Dental Guidelines (2005). No guidelines published by any institution in South Africa were found. The general rationale for the use of antibiotic prophylaxis for surgical (including dental) interventions is that those procedures may result in a bacteremia that may cause infection in joint prostheses. Antibiotics, however, should therefore be administered to susceptible patients, e.g. immunocompromised patients, prior to the development of bacteremia. The guidelines recommended for use in South Africa are based solely on those used outside South Africa. South Africa is regarded as a developing country with its own population and demographic characteristics. Eleven percent of our population is infected with HIV, and a specific guideline for prophylactic antibiotic treatment is, therefore, essential

Identifying sequence variation in cation channel sperm associated genes in Cape mountain zebra (Equus zebra zebra)

The Cape mountain zebra (Equus zebra zebra) has recovered from near extinction over more than eight decades. While their numbers have increased, populations remain isolated with low genetic diversity. With more than 75 new populations being founded and more than 4800 extant animals, conservation management strategies are being implemented to mitigate risk of losses in genetic diversity and reproductive fitness. One objective is to identify reproductive characteristics that may improve population growth. Cation channel sperm (CatSper) genes play an important role in hyperactivation of sperm during fertilization. Mutations in these genes lead to reduced fertility and even infertility. Ten male zebras were sampled from a group that were translocated in 2016 in order to found a new population. Single nucleotide polymorphisms (SNPs) were identified in three of the CatSper genes (1 - 3). Lack of variation was observed in all exons, with only four SNPs being identified in the intronic regions in close proximity to exons 1, 2, 7, 8, and 9 of CatSper 1. These results may contribute to the pre-identification of males for new founder populations to ensure population growth and viability, and may be a useful tool for selection against low-producing individuals

Introduction : climate justice in the Anthropocene

The need to address climate and environmental change becomes ever more urgent as climate harms and ecological destruction intensify and become more frequent. The articles in this issue emerged from a workshop in 2019, and they explore the multi-faceted nature of climate justice against the backdrop of the Anthropocene trope. The articles address specific issues such as corporate responsibility, the plight of farmers in India, climate displacement, and gender justice. In doing so, they reveal common themes such as the limitations and failings of business as usual and law as usual, the centrality of human rights and vulnerability theory in the pursuit of climate justice, the indivisibility of justice, and alternatives ways of achieving it

Earth System Law

The existing body of international environmental law has been created in the context of a relatively stable and harmonious Holocene epoch. This assumed regulatory premise of Holocene stability and harmony has resulted in a collection of international environmental law norms that are unable to sufficiently address the governance challenges emanating from within the context of the Anthropocene’s complex, unstable, unpredictable, and intertwined earth system. Earth system law has recently been proposed as an alternative vision for international environmental law in the Anthropocene. Earth system law is intended to serve as an imaginative framework that can guide innovative questions regarding the difficulties posed to international environmental law in responding to the complex challenges of earth system governance, and as a roadmap for international environmental law to better address these challenges on an appropriate planetary level in the Anthropocene

The relationship experiences of professional nurses with nurse managers

This qualitative study was undertaken to explore and describe the experiences of professional nurses in their relationships with nurse managers. Opsomming Hierdie kwalitatiewe studie is onderneem om die belewenisse van professionele verpleegkundiges ten opsigte van hulle verhoudings met verpleegbestuurders te verken en te beskryf. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text

Suicide cases investigated at the state mortuary in Bloemfontein, 2003–2007

Background: Up to 8 000 South Africans commit suicide annually. This study aimed to investigate the profile of suicide cases in Bloemfontein and the southern Free State province.Methods: A cross-sectional descriptive study was performed. Suicides in the Bloemfontein and southern Free State areas (Xhariep and Motheo districts) investigated at the state mortuary in Bloemfontein in 2003 to 2007 were included. Data were collected retrospectively by using a specially designed data-capturing form.Results: A total of 469 suicide cases were included in the study. The estimated suicide rate for this part of the Free State province was 10.9/100 000 of the population per year. The majority (82.1%) of the victims were men. In total, 338 (72.1%) of the victims were black, 122 (26.0%) were white, five (1.1%) were coloured and three (0.6%) were Indian. The most common methods were hanging (262; 55.9%), shooting (99; 21.1%) and overdosing on pills (43; 9.2%). Most cases (57.8%) occurred in victims 21 to 40 years of age. Five (1.1%) victims were children younger than 11 years of age, while 12 (2.6%) were older than 65 years. More than half (267 cases; 56.9%) of the suicide victims were unemployed. The majority(43.1%) of suicides occurred in January to April of each year, with the highest incidence (67 cases; 14.3%) in January. Conclusion: The rate of suicide and the profile of victims with regard to the variables investigated corresponded to findings reported from other studies. The information obtained could make a meaningful contribution to suicide-preventionprogrammes.Keywords: suicide; profile; rate; prevention; Free State Provinc

Observations from SANSA’s geomagnetic network during the Saint Patrick’s Day storm of 17–18 March 2015

Geomagnetic storms are space weather events that result in a temporary disturbance of the earth’s magnetosphere caused by a solar wind that interacts with the earth’s magnetic field. We examined more closely how some southern African magnetic observatories responded to the Saint Patrick’s Day storm using local K-indices. We show how this network of observatories may be utilised to model induced electric field, which is useful for the monitoring of geomagnetically induced anomalous currents capable of damaging power distribution infrastructure. We show an example of the correlation between a modelled induced electric field and measured geomagnetically induced currents in southern Africa. The data show that there are differences between global and local indices, which vary with the phases of the storm. We show the latitude dependence of geomagnetic activity and demonstrate that the direction of the variation is different for the X and Y components. Significance: • The importance of ground-based data in space weather studies is demonstrated. • We show how SANSA’s geomagnetic network may be utilised to model induced electric field, which is useful for the monitoring of geomagnetically induced anomalous currents capable of damaging power distribution infrastructure. Open data set:  http://www.intermagnet.org/data-donnee/download-eng.ph