378 research outputs found
Differential gene expression and co-regulated expression of genes in leukemia: an in-silico approach to identify potent biomarker
A biomarker can be measured, used to diagnose or classify disease, and measure progress as well as the therapeutic response of the disease. Early diagnosis and selection of appropriate treatment can be critical for the successful treatment of diseases. Identification and characterization of potent diagnostic biomarkers, and therapeutic targets rely heavily on traditional in vitro screens which require extensive resources and time. Integration of in silico screens prior to experimental validation can improve the efficiency and potency of biomarkers as well as reduce the cost and time of biomarker discovery. Considering the need, present work was undertaken to identify biomarkers for different classes of leukemia. Differential Gene Expression (DGE) analysis and co-regulated expression analysis were used for in silico identification and characterise a potent biomarker for leukemia. On the basis of in silico screening, the present study proposed seven protein-coding (CD38, TSC22D3, TNFRSF25, AGL, LARGE1, ARHGAP32, and PARM1) genes for the diagnosis of leukemia. The study also proposed a novel three-step lineage-specific model for the diagnosis of leukemia. In the three-step diagnosis model, the first group of biomarkers with an association of clinical and hematological parameters diagnose leukemia. The second group of biomarkers diagnoses acute and chronic form of leukemia. The third group of biomarkers identifies whether it belongs to myeloid lineage or lymphoid lineage
Taking nature into lab: biomineralization by heavy metal-resistant streptomycetes in soil
Biomineralization by heavy metal-resistant streptomycetes was tested to evaluate the potential influence on metal mobilities in soil. Thus, we designed an experiment adopting conditions from classical laboratory methods to natural conditions prevailing in metal-rich soils with media spiked with heavy metals, soil agar, and nutrientenriched or unamended soil incubated with the bacteria. As a result, all strains were able to form struvite minerals (MgNH4PO4 6H2O) on tryptic soy broth (TSB)-media supplemented with AlCl3, MnCl2 and CuSO4, as well as on soil agar. Some strains additionally formed struvite on nutrient-enriched contaminated and control soil, as well as on metal contaminated soil without addition of media components. In contrast, switzerite (Mn3(PO4)2 7H2O) was exclusively formed on minimal media spiked with MnCl2 by four heavy metal-resistant strains, and on nutrient-enriched control soil by one strain. Hydrated nickel hydrogen phosphate was only crystallized on complex media supplemented with NiSO4 by most strains. Thus, mineralization is a dominant property of streptomycetes, with different processes likely to occur under laboratory conditions and sub-natural to natural conditions. This new understanding might have implications for our understanding of biological metal resistance mechanisms. We assume that biogeochemical cycles, nutrient storage and metal resistance might be affected by formation and re-solubilization of minerals like struvite in soil at microscale
Central-moment description of polarization for quantum states of light
We present a moment expansion method for the systematic characterization of
the polarization properties of quantum states of light. Specifically, we link
the method to the measurements of the Stokes operator in different directions
on the Poincar\'{e} sphere, and provide a method of polarization tomography
without resorting to full state tomography. We apply these ideas to the
experimental first- and second-order polarization characterization of some
two-photon quantum states. In addition, we show that there are classes of
states whose polarization characteristics are dominated not by their
first-order moments (i.e., the Stokes vector) but by higher-order polarization
moments.Comment: 11 pages, 7 figures, 4 tables, In version 2, Figs. 2 and 4 are
replaced, Sec. IV extended, Sec. VIII revised, a few references adde
A luminosity monitor for the A4 parity violation experiment at MAMI
A water Cherenkov luminosity monitor system with associated electronics has
been developed for the A4 parity violation experiment at MAMI. The detector
system measures the luminosity of the hydrogen target hit by the MAMI electron
beam and monitors the stability of the liquid hydrogen target. Both is required
for the precise study of the count rate asymmetries in the scattering of
longitudinally polarized electrons on unpolarized protons. Any helicity
correlated fluctuation of the target density leads to false asymmetries. The
performance of the luminosity monitor, investigated in about 2000 hours with
electron beam, and the results of its application in the A4 experiment are
presented.Comment: 22 pages, 12 figures, submitted to NIM
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
We report on a measurement of the asymmetry in the scattering of transversely
polarized electrons off unpolarized protons, A, at two Q values of
\qsquaredaveragedlow (GeV/c) and \qsquaredaveragedhighII (GeV/c) and a
scattering angle of . The measured transverse
asymmetries are A(Q = \qsquaredaveragedlow (GeV/c)) =
(\experimentalasymmetry alulowcorr \statisticalerrorlow
\combinedsyspolerrorlowalucor) 10 and
A(Q = \qsquaredaveragedhighII (GeV/c)) = (\experimentalasymme
tryaluhighcorr \statisticalerrorhigh
\combinedsyspolerrorhighalucor) 10. The first
errors denotes the statistical error and the second the systematic
uncertainties. A arises from the imaginary part of the two-photon
exchange amplitude and is zero in the one-photon exchange approximation. From
comparison with theoretical estimates of A we conclude that
N-intermediate states give a substantial contribution to the imaginary
part of the two-photon amplitude. The contribution from the ground state proton
to the imaginary part of the two-photon exchange can be neglected. There is no
obvious reason why this should be different for the real part of the two-photon
amplitude, which enters into the radiative corrections for the Rosenbluth
separation measurements of the electric form factor of the proton.Comment: 4 figures, submitted to PRL on Oct.
Evidence for Strange Quark Contributions to the Nucleon's Form Factors at = 0.108 (GeV/c)
We report on a measurement of the parity violating asymmetry in the elastic
scattering of polarized electrons off unpolarized protons with the A4 apparatus
at MAMI in Mainz at a four momentum transfer value of = \Qsquare
(GeV/c) and at a forward electron scattering angle of 30. The measured asymmetry is = (\Aphys
\Deltastat \Deltasyst) 10. The
expectation from the Standard Model assuming no strangeness contribution to the
vector current is A = (\Azero \DeltaAzero) 10. We
have improved the statistical accuracy by a factor of 3 as compared to our
previous measurements at a higher . We have extracted the strangeness
contribution to the electromagnetic form factors from our data to be +
\FakGMs = \GEsGMs \DeltaGEsGMs at = \Qsquare (GeV/c).
As in our previous measurement at higher momentum transfer for + 0.230
, we again find the value for + \FakGMs to be positive,
this time at an improved significance level of 2 .Comment: 4 pages, 3 figure
Measurement of Strange Quark Contributions to the Nucleon's Form Factors at Q^2=0.230 (GeV/c)^2
We report on a measurement of the parity-violating asymmetry in the
scattering of longitudinally polarized electrons on unpolarized protons at a
of 0.230 (GeV/c)^2 and a scattering angle of \theta_e = 30^o - 40^o.
Using a large acceptance fast PbF_2 calorimeter with a solid angle of
\Delta\Omega = 0.62 sr the A4 experiment is the first parity violation
experiment to count individual scattering events. The measured asymmetry is
A_{phys} =(-5.44 +- 0.54_{stat} +- 0.27_{\rm sys}) 10^{-6}. The Standard Model
expectation assuming no strangeness contributions to the vector form factors is
. The difference is a direct measurement of the
strangeness contribution to the vector form factors of the proton. The
extracted value is G^s_E + 0.225 G^s_M = 0.039 +- 0.034 or F^s_1 + 0.130 F^s_2
= 0.032 +- 0.028.Comment: 5 pages, 3 figures, submitted to Phys. Rev. Letters on Dec 11, 200
A literature review of the predictive validity of European dental school selection methods
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Non peer reviewedPostprin
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