402 research outputs found
SUMC/MPOS/HAL interface study
The implementation of the HAL/S language on the IBM-360, and in particular the mechanization of its real time, I/O, and error control statements within the OS-360 environment is described. The objectives are twofold: (1) An analysis and general description of HAL/S real time, I/O, and error control statements and the structure required to mechanize these statements. The emphasis is on describing the logical functions performed upon execution of each HAL statement rather than defining whether it is accomplished by the compiler or operating system. (2) An identification of the OS-360 facilities required during execution of HAL/S code as implemented for the current HAL/S-360 compiler; and an evaluation of the aspects involved with interfacing HAL/S with the SUMC operating system utilizing either the HAL/S-360 compiler or by designing a new HAL/S-SUMC compiler
Standard interface definition for avionics data bus systems
Data bus for avionics system of space shuttle, noting functions of interface unit, error detection and recovery, redundancy, and bus control philosoph
Engineering study for a mass memory system for advanced spacecrafts Final report, 1 Dec. 1969 - 1 Jul. 1970
Mass memory system for advanced spacecraf
Locating, and Utilising \u3cem\u3eFestuca Pratensis\u3c/em\u3e Genes for Winter Hardiness for the Future Development of More Persistent High Quality \u3cem\u3eLolium\u3c/em\u3e Cultivars
Genes for freezing-tolerance and winter hardiness were located in Festuca pratensis by QTL analysis and introgression-mapping. QTL for freezing-tolerance on F. pratensis chromosome 4 were orthologous to rice chromosome 3, and Triticeae chromosome 5. Increased energy dissipation during the autumn through a lower maximum quantum yield of photosystem II (PSII) was correlated with improved winter survival. Freezing tolerance in Lolium was achieved by the transfer and subsequent expression of F. pratensis genes from chromosome 4 that govern the expression of a non-photochemical (NPQ) mechanism for the dissipation of excess light energy under low temperature
OFF-LINE HANDWRITING RECOGNITION USING VARIOUS HYBRID MODELING TECHNIQUES AND CHARACTER N-GRAMS
OFF-LINE HANDWRITING RECOGNITION USING VARIOUS HYBRID MODELING TECHNIQUES AND CHARACTER N-GRAMS
OFF-LINE HANDWRITING RECOGNITION USING VARIOUS HYBRID MODELING TECHNIQUES AND CHARACTER N-GRAMS
OFF-LINE HANDWRITING RECOGNITION USING VARIOUS HYBRID MODELING TECHNIQUES AND CHARACTER N-GRAMS
Comparison of PET/CT-based eligibility according to VISION and TheraP trial criteria in end-stage prostate cancer patients undergoing radioligand therapy
Background
Two randomized clinical trials demonstrated the efficacy of prostate-specific membrane antigen (PSMA) radioligand therapy (PSMA RLT) in metastatic castration-resistant prostate cancer (mCRPC). While the VISION trial used criteria within PSMA PET/CT for inclusion, the TheraP trial used dual tracer imaging including FDG PET/CT. Therefore, we investigated whether the application of the VISION criteria leads to a benefit in overall survival (OS) or progression-free survival (PFS) for men with mCRPC after PSMA RLT.
Methods
Thirty-five men with mCRPC who had received PSMA RLT as a last-line option and who had undergone pretherapeutic imaging with FDG and [68Ga]Ga-PSMA I&T or [18F]PSMA-1007 were studied. Therapeutic eligibility was retrospectively evaluated using the VISION and TheraP study criteria.
Results
26 of 35 (74%) treated patients fulfilled the VISION criteria (=âVISION+) and only 17 of 35 (49%) fulfilled the TheraP criteria (=âTheraP+). Significantly reduced OS and PFS after PSMA RLT was observed in patients rated VISIONâ compared to VISION+ (OS: VISIONâ: 3 vs. VISION+: 12 months, hazard ratio (HR) 3.1, 95% confidence interval (CI) 1.0â9.1, pâ<â0.01; PFS: VISIONâ: 1 vs. VISION+: 5 months, HR 2.7, 95% CI 1.0â7.8, pâ<â0.01). For patients rated TheraPâ, no significant difference in OS but in PFS was observed compared to TheraP+ patients (OS: TheraPâ: 5.5 vs. TheraP+: 11 months, HR 1.6, 95% CI 0.8â3.3, pâ=â0.2; PFS: TheraPâ: 1 vs. TheraP+: 6 months, HR 2.2, 95% CI 1.0â4.5, pâ<â0.01).
Conclusion
Retrospective application of the inclusion criteria of the VISION study leads to a benefit in OS and PFS after PSMA RL, whereas TheraP criteria appear to be too strict in patients with end-stage prostate cancer. Thus, performing PSMA PET/CT including a contrast-enhanced CT as proposed in the VISION trial might be sufficient for treatment eligibility of end-stage prostate cancer patients
High soluble transferrin receptor in patients with heart failure:a measure of iron deficiency and a strong predictor of mortality
Background:
Iron deficiency (ID) is frequent in heart failure (HF), linked with exercise intolerance and poor prognosis. Intravenous iron repletion improves clinical status in HF patients with LVEFâ€45%. However, uncertainty exists about the accuracy of serum biomarkers in diagnosing ID.
Study Aims: 1) to identify the iron biomarker with the greatest accuracy for the diagnosis of ID in bone marrow in patients with ischaemic HF; 2) to establish the prevalence of ID using this biomarker and its prognostic value in HF patients.
Methods and Results:
Bone marrow was stained for iron in 30 patients with ischaemic HF with LVEFâ€45% and 10 healthy controls, and ID was diagnosed for 0â1 grades (Gale scale). 791 patients with HF with LVEFâ€45% were prospectively followedâup for 3âyears. Serum ferritin, transferrin saturation, soluble transferrin receptor (sTfR) were assessed as iron biomarkers. Most patients with HF (25, 83%) had ID in bone marrow, but none of the controls (p<0.001). Serum sTfR had the best accuracy in predicting ID in bone marrow (AUC: 0.920, 95%CI: 0.761â0.987, for cutâoff 1.25 mg/L sensitivity 84%, specificity 100%). Serum sTfR was â„1.25 mg/L in 47% of HF patients, in 56% and 46% of anaemics and nonâanaemics, respectively (p<0.05). The reclassification methods revealed that serum sTfR significantly added the prognostic value to the baseline prognostic model, and to the greater extent than plasma NTâproBNP. Based on internal derivation and validation procedures, serum sTfR â„1.41 mg/L was the optimal threshold for predicting 3âyear mortality, independent of other established variables.
Conclusions:
High serum sTfR accurately reflects depleted iron stores in bone marrow in patients with HF, and identifies those with a high 3âyear mortality
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