Large angle magnetization dynamics measured by time-resolved ferromagnetic resonance

A time-resolved ferromagnetic resonance technique was used to investigate the magnetization dynamics of a 10 nm thin Permalloy film. The experiment consisted of a sequence of magnetic field pulses at a repetition rate equal to the magnetic systems resonance frequency. We compared data obtained by this technique with conventional pulsed inductive microwave magnetometry. The results for damping and frequency response obtained by these two different methods coincide in the limit of a small angle excitation. However, when applying large amplitude field pulses, the magnetization had a non-linear response. We speculate that one possible cause of the nonlinearity is related to self-amplification of incoherence, known as the Suhl instabilities.Comment: 23 pages, 8 figures, submitted to PR

Pulse wave velocity predicts mortality in renal transplant patients

<p>Abstract</p> <p>Background</p> <p>Measuring arterial stiffness using pulse wave velocity (PWV) has become an important tool to assess vascular function and cardiovascular mortality. For subject with hypertension, end-stage renal disease and diabetes, PWV has been shown to predict cardiovascular and all-cause mortality. We hypothesize that PWV would also predict mortality in subjects who have undergone kidney transplantation.</p> <p>Methods</p> <p>A cohort of 330 patients with renal transplantation was studied with a mean age at entry 51.4 ± 0.75 years. Mean follow-up was 3.8 years (± 0.7 years); 16 deaths occurred during follow-up. At entry, together with standard clinical and biochemical parameters, PWV was determined from pressure tracing over carotid and femoral arteries.</p> <p>Results</p> <p>With increasing PWV, there was a significant increase in age, systolic blood pressure and pulse pressure. In addition, subjects with higher PWV also exhibited more frequently the presence of coronary heart disease. On the basis of Cox analyses, PWV and systolic blood pressure emerged as predictors of all-cause mortality.</p> <p>Conclusion</p> <p>These results provide evidence that PWV is a strong predictor of all-cause mortality in the population of renal transplant recipients.</p

Схема управления техническим состоянием искусственных сооружений

For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version).ABSTRACT Reliability of artificial structures on the railways is directly related to safety of life of passengers and cargo. The proposed scheme of control of technical condition of the span allows to calculate with a great precision design reliability and to predict its changes, to respond flexibly to the dynamics of the operating conditions, as well as to control optimally the processes by the criterion «reliability-cost». Keywords: railway engineering structures, span, reliability, security, recursive algorithm, optimal interval. REFERENCES 1.GOST R54257-2010.Reliability of constructions and foundations.Fundamentals and requirements.Introduced on 01.09.2011 [GOST R54257-2010. Nadezhnost’ stroitel’nyh konstrukcij i osnovanij. Osnovnye polozhenija i trebovanija. Vved. 01.09.2011]. 2.Kos, O. I. Recursive algorithm for calculating and predicting the probability of failure-free operation of artificial structures [Rekurrentnyj algoritm rascheta i prognozirovanija verojatnosti bezotkaznoj raboty iskusstvennyh sooruzhenij].Transportnoe stroitel’stvo, 2016, Iss.6, pp.16-20. 3.Osipov, O. Durability of metal superstructures of operated railway bridges [Dolgovechnost’ metallicheskih proletnyh stroenij ekspluatiruemyh zheleznodorozhnyh mostov].Moscow, Transport publ., 1982, 287 p. 4.Smirnov, V. Yu., Kos, O. I. Optimum Time Spans of Preventive Replacements for Railway Engineering Structures.World of Transport and Transportation, Vol.11, 2013, Iss.1, pp.152-155. 5.Kos, O. I. Forecast of Wear of Metal Bridge Spans.World of Transport and Tranposrtation, Vol.12, 2014, Iss.5, pp.82-89. 6.Instruction on evaluation of state and maintenance of artificial structures on the railways of the Russian Federation / Department of track and structures of JSC Russian Railways [Instrukcija po ocenke sostojanija i soderzhanija iskusstvennyh sooruzhenij na zheleznyh dorogah Rossijskoj Federacii / Departament puti i sooruzhenij OAO «RZhD»].Moscow, 2006, 120 p. 7.Ryabinin, I. A. Reliability and safety of structurally complex systems [Nadezhnost’ i bezopasnost’ strukturno-slozhnyh system].St.Petersburg, Politehnika publ., 2000, 248 p. 8.Integrated Life-time Engineering of Buildings and Civil Infrastructures // 2nd International Symposim.2003, 640 p. 9.Barlow, R.E., Proschan, F. Mathematical Theory of Reliability.New York, Wiley, 1965, 258 p. 10.Walley, P. Statistical Reasoning with Imprecise Probabilities.London, Chapman and Hall, 1991, 706 p. 11.Linzhong, D. Artificial Intelligence Techniques for Bridge Reliability assessment, 2011, 188p.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).Надёжность искусственных сооружений на железных дорогах напрямую связана с обеспечением безопасности жизни пассажиров и грузов. Предложенная схема управления техническим состоянием пролётного строения позволяет с большой точностью рассчитывать надёжность конструкции и прогнозировать её изменения, гибко реагировать на динамику эксплуатационных условий, а также осуществлять оптимальное руководство процессами по критерию «надёжность-затраты»

ПРОГНОЗ ИЗНОСА МЕТАЛЛИЧЕСКИХ МОСТОВЫХ ПРОЛЕТОВ

To get an objective assessment of the actual technical condition of a bridge, a mathematical model of the wear of artificial structures is designed. Weilbull law has appeared to be the best instrument between all studied laws of distribution that could be used to describe wear function. The model assesses the technical condition and its prediction in relation to the operating artificial structures on railways. The proposed design scheme, and graphs of wear function of bridge structures create conditions that will ensure maximum reliability of superstructures with a minimum of support costs.Чтобы получить объективную оценку фактического технического состояния моста, строится математическая модель износа искусственного сооружения. На основании проведенного анализа из всех рассмотренных законов распределения в качестве оптимального для функции износа выбирается закон Вейбулла. С помощью модели производится оценка технического состояния и его прогнозирование применительно к эксплуатируемым на железных дорогах искусственным сооружениям. Предлагаемая расчетная схема, используемые графики функций износа мостовых конструкций создают условия, позволяющие обеспечить максимум надежности пролетных строений при минимуме поддерживающих затрат

Strain control of superlattice implies weak charge-lattice coupling in La0.5_{0.5}Ca0.5_{0.5}MnO3_3

We have recently argued that manganites do not possess stripes of charge order, implying that the electron-lattice coupling is weak [Phys Rev Lett \textbf{94} (2005) 097202]. Here we independently argue the same conclusion based on transmission electron microscopy measurements of a nanopatterned epitaxial film of La$_{0.5}$Ca$_{0.5}$MnO$_3$. In strain relaxed regions, the superlattice period is modified by 2-3% with respect to the parent lattice, suggesting that the two are not strongly tied.Comment: 4 pages, 4 figures It is now explained why the work provides evidence to support weak-coupling, and rule out charge orde

Особенности и структура автоматизированного магнитотерапевтического аппарата

Розглядаються питання розробки та особливості структури автоматизованого магнітотерапевтичного апарату (АМА) з можливостями широкого керування параметрами магнітного поля (магнітної індукції, частоти, тривалості імпульсів та форми поля). Були проведені дослідження розподілення постійної та змінної складових магнітного поля в самому індукторі та комплексі «індуктор-біологічний об'єкт» в магнітотерапевтичних апаратах (МТА) «ПОЛЮС-4», «МИТ-11» та виконано їх порівняння. На основі експериментальних і теоретичних досліджень запропонований спосіб імпульсної магнітотерапії та структура автоматизованого магнітотерапевтичного апарату з точно нормованими параметрами магнітного поля та заданими параметрами впливу в робочій зоні індуктора, контролем ефективності дії фізіотерапевтичної процедури.The questions of development and feature of structure of the automated magnetotherapy apparatus (AMA) are examined with possibilities of wide management of magnetic-field (magnetic induction, frequency, duration of impulses and field form) parameters. There were undertaken studies of distribution of permanent and variable constituents of magnetic-field in an inductor and complex "inductor-biological object" in the magnetotherapy apparatus (MTA) of "POLUS-4", "MIT-11" and performed their comparison. On the basis of experimental and theoretical researches an offer method of impulsive magnetotherapy and structure of the automated magnetotherapy apparatuses are with the exactly rationed parameters of magnetic-field and preset parameter of influence in the working zone of inductor, by control of efficiency of action of physical therapy procedure. A new method and the principle of automated magnetotherapy apparatus to control output parameters: magnetic induction, frequency, form fields, pulse duration.Рассматриваются вопросы разработки и особенности структуры автоматизированного магнитотерапевтического аппарата (АМА) с возможностями широкого управления параметрами магнитного поля (магнитной индукции, частоты, длительности импульсов и формы поля). Были проведены исследования распределения постоянной и переменной составляющих магнитного поля в самом индукторе и комплексе «индуктор-биологический объект» в магнитотерапевтических аппаратах «ПОЛЮС-4», «МИТ-11» и выполнено их сравнение. На основе экспериментальных и теоретических исследований предложен способ импульсной магнитотерапии и структура автоматизированного магнитотерапевтического аппарата с точно нормированными параметрами магнитного поля и заданными параметрами воздействия в рабочей зоне индуктора, контролем эффективности действия физиотерапевтической процедуры

Long-term second primary cancer risk in adolescent and young adult (15-39 years) cancer survivors:a population-based study in the Netherlands between 1989 and 2018

Background: Few studies have comprehensively investigated the long-term second cancer risk among adolescent and young adult (AYA, aged 15-39 years) cancer survivors. This study investigated the long-term second cancer risk by including the full range of first and second cancer combinations with at least 10 observations in the Netherlands between 1989 and 2018. Materials and methods: First and second primary cancer data of all 6-month AYA cancer survivors were obtained from the nationwide population-based Netherlands Cancer Registry. Excess cancer risk compared to the general population was assessed with standardized incidence ratio (SIR) and absolute excess risk (AER) statistics up to 25 years after diagnosis. Cumulative incidences were estimated, using death as a competing risk factor. Analyses were carried out with and without applying multiple cancer rules. Results: The cohort included 99 502 AYA cancer survivors. Male survivors had a 2-fold higher risk of developing any cancer compared to the general population, whereas this was around 1.3-fold in females. AERs were 17.5 and 10.1 per 10 000 person-years for males and females. The long-term excess risk of cancer was significantly higher for most first and second primary cancer combinations, but comparable and lower risk estimates were also observed. Application of the multiple cancer rules resulted in a noticeable risk underestimation in melanoma, testicular, and breast cancer survivors. Risk outcomes remained similar in most cases otherwise. The cumulative incidence of second cancer overall increased over time up to 8.9% in males and 10.3% in females at 25 years’ follow-up. Highest long-term cumulative incidences were observed among lymphoma survivors (13.3% males and 18.9% females). Conclusions: AYA cancer survivors have a higher cancer risk compared to the general population for most cancers up to 25 years after their initial cancer diagnosis. Additional studies that investigate risk factors for the specific cancer type combinations are needed to develop personalized follow-up strategies.</p

Long-term second primary cancer risk in adolescent and young adult (15-39 years) cancer survivors:a population-based study in the Netherlands between 1989 and 2018

Background: Few studies have comprehensively investigated the long-term second cancer risk among adolescent and young adult (AYA, aged 15-39 years) cancer survivors. This study investigated the long-term second cancer risk by including the full range of first and second cancer combinations with at least 10 observations in the Netherlands between 1989 and 2018. Materials and methods: First and second primary cancer data of all 6-month AYA cancer survivors were obtained from the nationwide population-based Netherlands Cancer Registry. Excess cancer risk compared to the general population was assessed with standardized incidence ratio (SIR) and absolute excess risk (AER) statistics up to 25 years after diagnosis. Cumulative incidences were estimated, using death as a competing risk factor. Analyses were carried out with and without applying multiple cancer rules. Results: The cohort included 99 502 AYA cancer survivors. Male survivors had a 2-fold higher risk of developing any cancer compared to the general population, whereas this was around 1.3-fold in females. AERs were 17.5 and 10.1 per 10 000 person-years for males and females. The long-term excess risk of cancer was significantly higher for most first and second primary cancer combinations, but comparable and lower risk estimates were also observed. Application of the multiple cancer rules resulted in a noticeable risk underestimation in melanoma, testicular, and breast cancer survivors. Risk outcomes remained similar in most cases otherwise. The cumulative incidence of second cancer overall increased over time up to 8.9% in males and 10.3% in females at 25 years’ follow-up. Highest long-term cumulative incidences were observed among lymphoma survivors (13.3% males and 18.9% females). Conclusions: AYA cancer survivors have a higher cancer risk compared to the general population for most cancers up to 25 years after their initial cancer diagnosis. Additional studies that investigate risk factors for the specific cancer type combinations are needed to develop personalized follow-up strategies.</p

Vitamin D and Risk of Neuroimaging Abnormalities.

Vitamin D deficiency has been linked with an increased risk of incident all-cause dementia and Alzheimer's disease. The aim of the current study was to explore the potential mechanisms underlying these associations by determining whether low vitamin D concentrations are associated with the development of incident cerebrovascular and neurodegenerative neuroimaging abnormalities. The population consisted of 1,658 participants aged ≥65 years from the US-based Cardiovascular Health Study who were free from prevalent cardiovascular disease, stroke and dementia at baseline in 1992-93. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were determined by liquid chromatography-tandem mass spectrometry from blood samples collected at baseline. The first MRI scan was conducted between 1991-1994 and the second MRI scan was conducted between 1997-1999. Change in white matter grade, ventricular grade and presence of infarcts between MRI scan one and two were used to define neuroimaging abnormalities. During a mean follow-up of 5.0 years, serum 25(OH)D status was not significantly associated with the development of any neuroimaging abnormalities. Using logistic regression models, the multivariate adjusted odds ratios (95% confidence interval) for worsening white matter grade in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25-50 nmol/L) were 0.76 (0.35-1.66) and 1.09 (0.76-1.55) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted odds ratios for ventricular grade in participants who were severely 25(OH)D deficient and deficient were 0.49 (0.20-1.19) and 1.12 (0.79-1.59) compared to those sufficient. The multivariate adjusted odds ratios for incident infarcts in participants who were severely 25(OH)D deficient and deficient were 1.95 (0.84-4.54) and 0.73 (0.47-1.95) compared to those sufficient. Overall, serum vitamin D concentrations could not be shown to be associated with the development of cerebrovascular or neurodegenerative neuroimaging abnormalities in Cardiovascular Health Study participants.The Cardiovascular Health Study was supported by contracts HHSN268201200036C, HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grant HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by AG023629, AG20098, AG15928 and HL084443 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at chs-nhlbi.org. Additional support was also provided by NIRG-11-200737 from the Alzheimer’s Association, the Mary Kinross Charitable Trust, the James Tudor Foundation, the Halpin Trust, the Age Related Diseases and Health Trust, and the Norman Family Charitable Trust (to D.J.L.). This research was supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South West Peninsula at the Royal Devon and Exeter NHS Foundation Trust. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The National Institutes of Health was involved in the original design and conduct of the Cardiovascular Health Study and in the data collection methods