Drivers of Private Equity Investment in CEE and Western European Countries

A strong private equity market is a cornerstone for commercialization and innovation in modern economies. However, substantial differences exist in the relative amounts raised and invested in private equity across European countries. We investigate the macro-determinants of private equity investment in Europe, focusing on the comparison between CEE and Western European countries. Our estimations are based on a data set running from 2001 to 2008 and covers 14 Western European and three CEE countries. Applying robust estimation techniques we identify a 'robust' set of determinants of private equity activity in both regions. We find similarities as well as differences in the driving forces of private equity investments in Western European and CEE countries. Our results suggest that commercial bank lending, equity market capitalization, unit labour costs and corporate tax rates are significant determinants of private equity activity

Heterozygous ANKRD17 loss-of-function variants cause a syndrome with intellectual disability, speech delay, and dysmorphism

ANKRD17 is an ankyrin repeat-containing protein thought to play a role in cell cycle progression, whose ortholog in Drosophila functions in the Hippo pathway as a co-factor of Yorkie. Here, we delineate a neurodevelopmental disorder caused by de novo heterozygous ANKRD17 variants. The mutational spectrum of this cohort of 34 individuals from 32 families is highly suggestive of haploinsufficiency as the underlying mechanism of disease, with 21 truncating or essential splice site variants, 9 missense variants, 1 in-frame insertion-deletion, and 1 microdeletion (1.16 Mb). Consequently, our data indicate that loss of ANKRD17 is likely the main cause of phenotypes previously associated with large multi-gene chromosomal aberrations of the 4q13.3 region. Protein modeling suggests that most of the missense variants disrupt the stability of the ankyrin repeats through alteration of core structural residues. The major phenotypic characteristic of our cohort is a variable degree of developmental delay/intellectual disability, particularly affecting speech, while additional features include growth failure, feeding difficulties, non-specific MRI abnormalities, epilepsy and/or abnormal EEG, predisposition to recurrent infections (mostly bacterial), ophthalmological abnormalities, gait/balance disturbance, and joint hypermobility. Moreover, many individuals shared similar dysmorphic facial features. Analysis of single-cell RNA-seq data from the developing human telencephalon indicated ANKRD17 expression at multiple stages of neurogenesis, adding further evidence to the assertion that damaging ANKRD17 variants cause a neurodevelopmental disorder.Neurolog

Simulação estocástica da radiação fotossinteticamente ativa e da temperatura do ar por diferentes métodos Random simulation of photosynthetically active radiation and air temperature through different methods

O objetivo deste trabalho foi comparar três métodos para simulação de dados de radiação fotossinteticamente ativa e temperatura do ar, com o uso de parâmetros diários de 17 estações do Estado de São Paulo. A simulação foi realizada para o primeiro e o 16º dia de cada mês, conforme: a distribuição normal truncada a mais ou menos 1,96 de desvio-padrão; distribuição triangular assimétrica; e distribuição normal bivariada. As estimativas com os dados simulados foram comparadas com os respectivos parâmetros (obtidos com os dados observados), pelos testes de homogeneidade de variância F e Bartlett, teste t de comparação de médias, coeficiente de correlação de Pearson, índice de concordância de Willmott, índice de desempenho de Camargo, coeficiente angular e o teste de normalidade dos dados. A simulação pela distribuição normal bivariada é a mais adequada para representar as variáveis climáticas.<br>The purpose of this work was to compare three methods for simulating data of photosynthetically active radiation and air temperature, using daily parameters of 17 stations of São Paulo State, Brazil. The simulation of those elements was carried out for de 1st and the 16th day of each month, through three cases: nonsymmetric triangular distribution; normal distribution truncated at 1.96 standard deviation; and bivaried normal distribution. The simulated data were evaluated through the tests of homogeneity of variance F and Bartlett, t test, agreement index of Willmott, angular coefficient of the straight line, the index of performance of Camargo and tack the normal distribution (uni-varied). The simulation using the bi-varied normal distribution is most appropriate for representing the climate variables