Synthesis of β-(trifluoromethyl)furans and spiro-gem- dichlorocyclopropanes from cyclic 1,3-dicarbonyl compounds and α-(trihaloethylidene)nitroethanes

While 1,3-dicarbonyl compounds react with (E)-1,1,1-trifluoro-3-nitrobut-2- ene in the presence of sodium acetate to produce the target β- (trifluoromethyl)furans, their reaction with (E)-1,1,1-trichloro-3-nitrobut-2- ene, under the same conditions, took an entirely different course and gave spiro-gem-dichlorocyclopropanes bearing a 1-nitroethyl moiety, with high diastereoselectivity and in good yields. © 2013 Elsevier Ltd. All rights reserved

Domino reaction of 3-nitro-2-(trifluoromethyl)-2H-chromenes with 2-(1-phenylalkylidene)malononitriles: Synthesis of functionalized 6-(trifluoromethyl)-6H-dibenzo[b,d]pyrans and a rare case of [1,5] sigmatropic shift of the nitro group

A variety of functionalized 6-(trifluoromethyl)-6H-dibenzo[b,d]pyrans were easily synthesized in good yields under mild conditions by a domino reaction of 3-nitro-2-(trifluoromethyl)-2H-chromenes with 2-(1-phenylethylidene)- and 2-(1-phenylpropylidene)malononitriles. In the latter case, intermediate 7-amino-10-methyl-10-nitro-9-phenyl-6-(trifluoromethyl)-10,10a-dihydro-6H- benzo[c]chromene-8-carbonitriles were isolated as a result of a rare [1,5] sigmatropic shift of the nitro group. © 2013 Elsevier Ltd. All rights reserved

Synthesis of 5-(trifluoromethyl)-5H-chromeno[3,4-b]pyridines from 3-nitro-2-(trifluoromethyl)-2H-chromenes and aminoenones derived from acetylacetone and cyclic amines

Reactions of 3-nitro-2H-chromenes with aminoenones derived from acetylacetone and cyclic amines proceed diastereoselectively to give functionalized 2,3,4-trisubstituted chromanes as a result of nucleophilic addition of the vinylogous β-methyl group at the C-4 atom of the chromene system. From these compounds, under acidic conditions, 5-(trifluoromethyl)-5H- chromeno[3,4-b]pyridines and 4-acetoacetonyl-3-nitro-2-(trichloromethyl/phenyl) chromanes, depending on the substituent at the 2-position, were obtained in moderate to good yields. © 2013 Elsevier Ltd. All rights reserved

Highly regio-and stereoselective addition of ethyl 3-aminobut-2-enoates to 2-substituted 3-nitro-2H-chromenes

Ethyl 3-aminobut-2-enoates MeC(NHR)=CHCO2Et (R = H, Me, Bn) whose reaction site is C(2) atom add to 2-R-3-nitro-2H-chromenes at their C(4) atom to give the corresponding trans,trans-2,3,4-trisubstituted chromanes. Analogous substrates MeC(NR2)=CHCO2Et (NR2 is piperidin-1-yl or morpholin-4-yl) react by their C(4) methyl group to afford cis,trans-2,3,4-trisubstituted chromanes. The stereochemistry of the products was established by X-ray diffraction analysis. © 2013 Mendeleev Communications. All rights reserved

Highly diastereoselective 1,3-dipolar cycloaddition of nonstabilized azomethine ylides to 3-nitro-2-trihalomethyl-2H-chromenes: Synthesis of 1-benzopyrano[3,4-c]pyrrolidines

Reactions of 3-nitro-2-trifluoro(trichloro)methyl-2H-chromenes, including 2-unsubstituted derivatives, with N-alkyl-α-amino acids (sarcosine, proline) and paraformaldehyde proceed diastereoselectively to give 1-benzopyrano[3,4-c]pyrrolidines in good yields as a result of a 1,3-dipolar cycloaddition of the intermediate nonstabilized azomethine ylide at the Δ3-bond of the chromene system. © 2013 Elsevier Ltd. All rights reserved

Methods of labor economy increasing in educational organization

The urgency of problem under investigation due to fact that increasing demand of the information technology infrastructure development in current conditions of educational institutions functioning, including formation of the information-educational environment point of view. Offered organizational and economic model of constructing processes for software development is based on agile project management, regarded as an object-oriented tool for optimizing labor economics. The purpose of article is in model for labor economy processes optimization as a part of software development based on agile project management methodology in departments associated with development of information technologies in educational organization. The leading method to the problem study is in measurement of labor economics key indicators, including specific metrics of technical expert’s human capital growth. As an experimental base of research are considered educational organizations, at different times, using classical approach for software development and agile project management. The article presents research results of educational organizations departments engaged in project activities for development of information technologies, which are in the development of software products using classical approach for software development and agile project management. Article submissions may be useful to create a culture for constructing labor economics and human capital system based on sustainable growth in departments of educational institutions working in the field of information technology. © 2016 Dorozhkin et al

Black Sea coastal forecasting system

The Black Sea coastal nowcasting and forecasting system was built within the framework of EU FP6 ECOOP (European COastalshelf sea OPerational observing and forecasting system) project for five regions: the south-western basin along the coasts of Bulgaria and Turkey, the north-western shelf along the Romanian and Ukrainian coasts, coastal zone around of the Crimea peninsula, the north-eastern Russian coastal zone and the coastal zone of Georgia. The system operates in the real-time mode during the ECOOP project and afterwards. The forecasts include temperature, salinity and current velocity fields. Ecosystem model operates in the off-line mode near the Crimea coast

Diversity-Oriented Synthesis of Novel Trihalomethyl-Containing Spirochromeno[3,4- a ](thia)pyrrolizidines and Spirochromeno-[3,4- a ]indolizidines by One-Pot, Three-Component [3+2]-Cyclo addition Reaction

Regio- and stereoselective methods for the synthesis of 6′-trifluoro(trichloro)methyl substituted spiro[acenaphthylene-1,11′-chromeno[3,4- a ](thia)pyrrolizidin]-2-ones and spiro[acenaphthylene-1,12′-chromeno[3,4- a ]indolizidin]-2-ones have been developed based on the three-component reaction of 3-nitro-2-trifluoro(trichloro)methyl-2 H -chromenes with azomethine ylides generated in situ from acenaphthenequinone and cyclic α-amino acids. The cycloaddition proceeds under mild conditions in ethanol or DMSO, and only endo -isomers of the products with cis -arrangement of nitro and trifluoromethyl groups are formed. The relative configuration of cycloadducts is reliably confirmed by X-ray diffraction analysis and by 2D NOESY spectroscopy. © 2021 Georg Thieme Verlag. All rights reserved.The work was financially supported by the Russian Foundation for Basic Research (grant 20-03-00716) and by the Ministry of Science and Higher Education of the Russian Federation (project FEUZ-2020-0052)

Technology of implementation of the software module 1C: University in activities of primary labour union employee organization of a higher education institution

The relevance of the researched problem is caused by the need for management process automation of the organization and an insufficient readiness of theoretical, informatory-technological and scientific-methodical aspects of implementation of software products for university activities. The purpose of the presented article consists in development of technology of implementation of the software module 1C: UNIVERSITY in activities of labour union and its approbation. The leading method of the research of this problem is the modeling that enables to consider this problem as a process of purposeful and conscious management decision on management process improvement of an organization. The methodology of implementation of the software module of 1C: UNIVERSITY into activities of labour union is presented in the article; the methodology consists of the weighed and reasoned stages; their features and problems of implementation are revealed. The technology is focused on improvement and simplification of a management activity at Primary labour union organization of university and oriented to the development of scientific and methodical ensuring process of automation of activities of the educational organizations; the materials of this article can be useful to heads of the labour union organizations adapting to new conditions of a management activity in the sphere of electronic document flow, for specialists in the field of implementation of the software of automated control systems of the organization. © 2017