8,748 research outputs found
Information and display requirements for aircraft terrain following
The display design procedure for manned vehicle systems, is applied and validated, for a particular scenario. The scenario chosen is that of zero visibility high speed terrain following (V = 466 ft/sec, H = 200 ft) with an A-10 aircraft. The longitudal (linearized) dynamics are considered. The variations in (command path over) terrain pi(t) are modeled as a third order random process. The display design methodology is based on the optimal control model of pilot response, and employs this model in various ways in different phases of the design process. The overall methodology indicates that the design process is intended as a precursor to manned simulation. It provides a rank ordering of candidate displays through a three level process
Modeling the effects of high-G stress on pilots in a tracking task
Air-to-air tracking experiments were conducted at the Aerospace Medical Research Laboratories using both fixed and moving base dynamic environment simulators. The obtained data, which includes longitudinal error of a simulated air-to-air tracking task as well as other auxiliary variables, was analyzed using an ensemble averaging method. In conjunction with these experiments, the optimal control model is applied to model a human operator under high-G stress
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Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver.
We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions of up to 2 x 10(12) viral particles. Hepatic toxicity was the primary dose-limiting toxicity observed in preclinical models. However, nearly 200 infusions of this adenoviral vector were administered directly into the hepatic artery without significant toxicity. Therefore, we undertook this analysis to determine the impact of repeated adenoviral exposure on hepatic function. Seventeen patients were treated at our institution, providing a detailed data set on the changes in hepatic function following repeated exposure to adenovirus. No changes in hepatic function occurred with the first treatment of Onyx-015 among these patients. Transient increases in transaminase levels occurred in one patient starting with the second infusion and transient increases in bilirubin was observed in two patients starting with the fifth treatment. These changes occurred too early to be explained by viral-mediated lysis of hepatocytes. In addition, viremia was observed starting 3-5 days after the viral infusion in half of the patient, but was not associated with hepatic toxicity. To further understand the basis for the minimal hepatic toxicity of adenoviral vectors, we evaluated the replication of adenovirus in primary hepatocytes and tumor cells in culture and the expression of the coxsackie-adenoviral receptor (CAR) in normal liver and colon cancer metastatic to the liver. We found that adenovirus replicates poorly in primary hepatocytes but replicates efficiently in tumors including tumors derived from hepatocytes. In addition, we found that CAR is localized at junctions between hepatocytes and is inaccessible to hepatic blood flow. CAR is not expressed on tumor vasculature but is expressed on tumor cells. Spatial restriction of CAR to the intercellular space in normal liver and diminished replication of adenovirus in hepatocytes may explain the minimal toxicity observed following repeated hepatic artery infusions with Onyx-015
Design of helicopter rotor blades for optimum dynamic characteristics
The mass and stiffness distributions for helicopter rotor blades are tailored in such a way to give a predetermined placement of blade natural frequencies. The optimal design is pursued with respect of minimum weight, sufficient inertia, and reasonable dynamic characteristics. Finite element techniques are used as a tool. Rotor types include hingeless, articulated, and teetering
Reversable heat flow through the carbon nanotube junctions
Microscopic mechanisms of externally controlled reversable heat flow through
the carbon nanotube junctions (NJ) are studied theoretically. Our model
suggests that the heat is transfered along the tube section by
electrons () and holes () moving ballistically in either in parallel or
in opposite directions and accelerated by the bias source-drain voltage (Peltier effect). We compute the Seebeck coefficient , electric
and thermal conductivities and find that their magnitudes
strongly depend on and . The sign reversal of
versus the sign of formerly observed experimentally is interpreted
in this work in terms of so-called chiral tunneling phenomena (Klein paradox)
Hole spin dynamics and hole factor anisotropy in coupled quantum well systems
Due to its p-like character, the valence band in GaAs-based heterostructures
offers rich and complex spin-dependent phenomena. One manifestation is the
large anisotropy of Zeeman spin splitting. Using undoped, coupled quantum wells
(QWs), we examine this anisotropy by comparing the hole spin dynamics for high-
and low-symmetry crystallographic orientations of the QWs. We directly measure
the hole factor via time-resolved Kerr rotation, and for the low-symmetry
crystallographic orientations (110) and (113a), we observe a large in-plane
anisotropy of the hole factor, in good agreement with our theoretical
calculations. Using resonant spin amplification, we also observe an anisotropy
of the hole spin dephasing in the (110)-grown structure, indicating that
crystal symmetry may be used to control hole spin dynamics
Pristine CNO abundances from Magellanic Cloud B stars II. Fast rotators in the LMC cluster NGC 2004
We present spectroscopic abundance analyses of three main-sequence B stars in
the young Large Magellanic Cloud cluster NGC 2004. All three targets have
projected rotational velocities around 130 km/s. Techniques are presented that
allow the derivation of stellar parameters and chemical abundances in spite of
these high v sin i values. Together with previous analyses of stars in this
cluster, we find no evidence among the main-sequence stars for effects due to
rotational mixing up to v sin i around 130 km/s. Unless the equatorial
rotational velocities are significantly larger than the v sin i values, this
finding is probably in line with theoretical expectations. NGC 2004/B30, a star
of uncertain evolutionary status located in the Blue Hertzsprung Gap, clearly
shows signs of mixing in its atmosphere. To verify the effects due to
rotational mixing will therefore require homogeneous analysis of statistically
significant samples of low-metallicity main-sequence B stars over a wide range
of rotational velocities.Comment: 12 pages, 5 figures, 2 tables; accepted for publication in ApJ (vol.
633, p. 899
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