Non-biomimetic route to deoxyadenosine adducts of carcinogenic polycyclic aromatic hydrocarbons

Aminotriols are prepared by direct aminolysis of the diol epoxides of polycyclic aromatic hydrocarbons, providing a substantial improvement over literature methods. The condensation of aminotriols with 6-halopurine deoxyribonucleosides provides a regio- and stereospecific synthesis of deoxyadenosine N6 adducts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29083/1/0000118.pd

Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives

15 Cyclohexane epoxide derivatives were synthesized and compared for direct mutagenicity an bacterial toxicity using Salmonella typhimurium strain TA100 in the liquid suspension and spot-test version of the Ames procedure. While no general correlations could be established for position and stereochemistry of the hydroxylated derivatives, an increase in mutagenicity was noted for the presence of electron-withdrawing groups and unsaturation in conjugation with the oxirane groups.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25651/1/0000203.pd

Prediction of flux loss in a Nd-Fe-B ring magnet considering magnetizing process

We developed a technique to predict flux loss of a magnet with a complicated magnetization pattern using the finite element method. The developed method consists of four steps. At first, the distribution of magnetization under magnetizing field is analyzed (Step 1), and a demagnetization curve of each element is deduced from the result of the first step (Step 2). After removing the magnetizing field, the distributions of magnetization at room and elevated temperatures are analyzed by using demagnetization curves determined in Step 2 (Step 3). Based on a physical model, the distribution of flux loss due to exposure at the elevated temperature is predicted by using the result obtained in Step 3 (Step 4). We applied this technique to a ring magnet with 10 poles, and large flux loss values were predicted at the transition regions between magnetic poles.International Conference on Magnetism, ICM 2009; Karlsruhe; 26 July 2009 through 31 July 200