Non-biomimetic route to deoxyadenosine adducts of carcinogenic polycyclic aromatic hydrocarbons

Abstract

Aminotriols are prepared by direct aminolysis of the diol epoxides of polycyclic aromatic hydrocarbons, providing a substantial improvement over literature methods. The condensation of aminotriols with 6-halopurine deoxyribonucleosides provides a regio- and stereospecific synthesis of deoxyadenosine N6 adducts.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29083/1/0000118.pd

    Similar works