The attitudes toward forcible date rape (FDR) scale: Development of a measurement model

Using data from 341 female and 237 male college students that were collected previously (Fischer, G. J., Archives of Sexual Behavior , 15, 457–466, 1986), several true score measurement models were used to describe the variance-covariance structure of a nine-item attitude toward a forcible date rape (FDR) scale. The congeneric true score model fit the data best, but not satisfactorily. By deleting “noncongeneric” items, a six-item, unweighted linear composite variable based on the congeneric true score model was shown to fit the data, and reliabilities and validities based on this model proved satisfactory for females, males, and the total sample. The factor structure of the model for females and for males was not equivalent, but the general patterns were similar. Suggestions for further research included a validation study of the six-item scale on an independent sample and a comparison of 5-and 7-point Likert response scales to see if the lack of model equivalence by gender could be due, in part, to more variability in attitudes toward forcible date rape in men than women.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44789/1/10862_2005_Article_BF02229064.pd

Conflicting genomic signals affecting phylogenetic inference in four species of North American pines

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.Adaptive evolutionary processes in plants may be accompanied by episodes of introgression, parallel evolution and incomplete lineage sorting that pose challenges in untangling species evolutionary history. Genus Pinus (pines) is one of the most abundant and most studied groups among gymnosperms, and a good example of a lineage where these phenomena have been observed. Pines are among the most ecologically and economically important plant species. Some, such as the pines of the southeastern USA (southern pines in subsection Australes), are subjects of intensive breeding programs. Despite numerous published studies, the evolutionary history of Australes remains ambiguous and often controversial. We studied the phylogeny of four major southern pine species: shortleaf (Pinus echinata), slash (P. elliottii), longleaf (P. palustris) and loblolly (P. taeda), using sequences from 11 nuclear loci and maximum likelihood and Bayesian methods. Our analysis encountered resolution difficulties similar to earlier published studies. Although incomplete lineage sorting and introgression are two phenomena presumptively underlying our results, the phylogenetic inferences seem to be also influenced by the genes examined, with certain topologies supported by sets of genes sharing common putative functionalities. For example, genes involved in wood formation supported the clades echinata–taeda, genes linked to plant defence supported the clade echinata–elliottii, whereas genes linked to water management properties supported the clade echinata-palustris. The support for these clades was very high and consistent across methods. We discuss the potential factors that could underlie these observations, including incomplete lineage sorting, hybridization and parallel or adaptive evolution. Our results likely reflect the relatively short evolutionary history of the subsection that is thought to have begun during the middle Miocene and has been influenced by climate fluctuations

Conflicting genomic signals affecting phylogenetic inference in four species of North American pines

Текст статьи не публикуется в открытом доступе в соответствии с политикой журнала.Adaptive evolutionary processes in plants may be accompanied by episodes of introgression, parallel evolution and incomplete lineage sorting that pose challenges in untangling species evolutionary history. Genus Pinus (pines) is one of the most abundant and most studied groups among gymnosperms, and a good example of a lineage where these phenomena have been observed. Pines are among the most ecologically and economically important plant species. Some, such as the pines of the southeastern USA (southern pines in subsection Australes), are subjects of intensive breeding programs. Despite numerous published studies, the evolutionary history of Australes remains ambiguous and often controversial. We studied the phylogeny of four major southern pine species: shortleaf (Pinus echinata), slash (P. elliottii), longleaf (P. palustris) and loblolly (P. taeda), using sequences from 11 nuclear loci and maximum likelihood and Bayesian methods. Our analysis encountered resolution difficulties similar to earlier published studies. Although incomplete lineage sorting and introgression are two phenomena presumptively underlying our results, the phylogenetic inferences seem to be also influenced by the genes examined, with certain topologies supported by sets of genes sharing common putative functionalities. For example, genes involved in wood formation supported the clades echinata–taeda, genes linked to plant defence supported the clade echinata–elliottii, whereas genes linked to water management properties supported the clade echinata-palustris. The support for these clades was very high and consistent across methods. We discuss the potential factors that could underlie these observations, including incomplete lineage sorting, hybridization and parallel or adaptive evolution. Our results likely reflect the relatively short evolutionary history of the subsection that is thought to have begun during the middle Miocene and has been influenced by climate fluctuations

MAGNETOOPTICAL SPECTROSCOPY OF THE Q TRANSITION OF ZINC TETRABENZOPORPHYRIN ISOLATED IN AN ARGON MATRIX.

Author Institution: Department of Chemistry, University of Canterbury; Department of Chemistry, University of VirginiaAbsorption, fluorescence, magnetic circular dichroism (MCD), magnetic circularly polarized luminscence (MCPL) and longitudinal Zeeman spectra were measured for the $Q(^{1}A^{1}_{g}(\pi)) \rightarrow ^{1}E_{u}(\pi^{*}e)$ transition of zinc tetra benzoporphyrin isolated in an argon matrix (ZnTBP/Ar). Moment analysis of the MCD and absorption yield an excited-state orbital g value of $g_{1} = 7.7 \pm 0.4$. The large value of this parameter is consistent with a four-orbital interpretation of the Q transition for metallophthalocyanines. The magnetic field dependence of the zero-phonon Zeeman shifts and moment analysis of the emission spectra independently yield information concerning Jahn-Teller (JT) effects in the excited state. These data have been interpreted in the context of a single effective JT-active coordinate and local crystal-field distortions of both $b_{1}g$ and $b_{2}g$ symmetry. [FIGURE]

Exome genotyping, linkage disequilibrium and population structure in loblolly pine (Pinus taeda L.)

Background: Loblolly pine (Pinus taeda L.) is one of the most widely planted and commercially important forest tree species in the USA and worldwide, and is an object of intense genomic research. However, whole genome resequencing in loblolly pine is hampered by its large size and complexity and a lack of a good reference. As a valid and more feasible alternative, entire exome sequencing was hence employed to identify the gene-associated single nucleotide polymorphisms (SNPs) and to genotype the sampled trees. Results: The exons were captured in the ADEPT2 association mapping population of 375 clonally-propagated loblolly pine trees using NimbleGen oligonucleotide hybridization probes, and then exome-enriched genomic DNA fragments were sequenced using the Illumina HiSeq 2500 platform. Oligonucleotide probes were designed based on 199,723 exons (≈49 Mbp) partitioned from the loblolly pine reference genome (PineRefSeq v. 1.01). The probes covered 90.2 % of the target regions. Capture efficiency was high; on average, 67 % of the sequence reads generated for each tree could be mapped to the capture target regions, and more than 70 % of the captured target bases had at least 10X sequencing depth per tree. A total of 972,720 high quality SNPs were identified after filtering. Among them, 53 % were located in coding regions (CDS), 5 % in 5' or 3' untranslated regions (UTRs) and 42 % in non-target and non-coding regions, such as introns and adjacent intergenic regions collaterally captured. We found that linkage disequilibrium (LD) decayed very rapidly, with the correlation coefficient (r2) between pairs of SNPs linked within single scaffolds decaying to half maximum (r2 = 0.22) within 55 bp, to r2 = 0.1 within 192 bp, and to r2 = 0.05 within 451 bp. Population structure analysis using unlinked SNPs demonstrated the presence of two main distinct clusters representing western and eastern parts of the loblolly pine range included in our sample of trees. Conclusions: The obtained results demonstrated the efficiency of exome capture for genotyping species such as loblolly pine with a large and complex genome. The highly diverse genetic variation reported in this study will be a valuable resource for future genetic and genomic research in loblolly pine

The double sensor-a non-invasive device to continuously monitor core temperature in humans on earth and in space

The objective of our study was to establish whether rectal temperature recordings in humans could be replaced by a non-invasive skin temperature sensor combined with a heat flux sensor (Double Sensor) located at the forehead to monitor core body temperature changes due to circadian rhythms. Rectal and Double Sensor data were collected continuously for 24h in seven men undertaking strict head-down tilt bed-rest. Individual differences between the two techniques varied between -0.72 and +0.55 degrees C. Nonetheless, when temperature data were approximated by cosinor analysis in order to compare circadian rhythm profiles between methods, it was observed that there were no significant differences between mesor, amplitude, and acrophase (P>0.310). It was therefore concluded that the Double Sensor technology is presently not accurate enough for performing single individual core body temperature measurements under resting conditions at normal ambient room temperature. Yet, it seems to be a valid, non-invasive alternative for monitoring circadian rhythm profiles

Discovery of OATD 01 , a First in Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

Chitotriosidase CHIT1 and acidic mammalian chitinase AMCase are the enzymatically active chitinases that have been implicated in the pathology of chronic lung diseases such as asthma and interstitial lung diseases ILDs , including idiopathic pulmonary fibrosis IPF and sarcoidosis. The clinical and preclinical data suggest that pharmacological inhibition of CHIT1 might represent a novel therapeutic approach in IPF. Structural modification of an advanced lead molecule 3 led to the identification of compound 9 OATD 01 , a highly active CHIT1 inhibitor with both an excellent PK profile in multiple species and selectivity against a panel of other off targets. OATD 01 given orally once daily in a range of doses between 30 and 100 mg kg showed significant antifibrotic efficacy in an animal model of bleomycin induced pulmonary fibrosis. OATD 01 is the first in class CHIT1 inhibitor, currently completed phase 1b of clinical trials, to be a potential treatment for IP