3 research outputs found
7,7'-Bis[(aza-18-crown-6)carbonyl]thioindigo: Synthesis, Experimental, Theoretical Characterization and Biological Activities
This work presents the characterization of 7,7'-Bis[(aza-18-crown-6)carbonyl]thioindigo (I) by quantum chemical calculations and spectral techniques. The molecular geometry, frontier molecular orbitals (FMO), molecular electrostatic potentials (MEP) and nonlinear optical properties of I in the ground state have been calculated using the density functional method (B3LYP) with the 6−31G(d,p) basis set. The calculated results show that the optimized geometry can well reproduce the crystal structure. The predicted non-linear optical properties of I are greater than ones of urea. The title compound has been tested in vitro for biological effects. The title compound was found to exhibit significant antimicrobial and antioxidant activit
Synthesis and characterization of novel chiral (1r,2r)-1,2-bis[5-(aminomethylphospinic acid)-1,3,4-thiadiazol-2-yl]ethane-1,2-diols
WOS: 000304595400008(1R,2R)-1,2-bis[5-(arylideneamino)-1,3,4-thiadiazol-2-yl]ethane-1,2-diol (2a-d) were synthesized by using appropriate aldehydes and (1R,2R)-1,2-bis(5-amino-1,3,4-thiadiazol-2-yl)ethane-1,2-diol (1) as a starting compound. Then, the phosphinic acid component (3a-d) were obtained from (2a-d) and hypophosporus acid. In addition, the structures of the novel chiral compounds (2a-d) and (3a-d) were confirmed by elemental analyses, IR, H-1-NMR, C-13-NMR, and P-31-NMR spectra. H-1 NMR and C-13 NMR spectra for 1, 2a, and 3a (Figures S1-S6) are available online in the Supplemental Materials.Firat University (FUBAP) [FF.11.17]This work was supported by Grant no. FF.11.17 of the Research Fund of Firat University (FUBAP)
Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole
In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant
vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high
performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae
cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of
results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed
effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the
selection and design of model compounds for further studies