Missing Persons: Cherokee\u27s Parrot and Chatterton\u27s Poet

This essay explores the problematic nature of selfhood in the detective genre as established by Edgar Allan Poe\u27s Murders in the Rue Morgue (1841) and most recently reformulated in two metaphysical detective novels, Jean Echenoz\u27s Cherokee (1983) and Peter Ackroyd\u27s Chatterton (1987). Poe\u27s detective Auguste Dupin is described as having a Bi-Part Soul, which permits him to vacate himself in order to construct the narrative solution to a crime. This duality, in the postmodern detective novel, is transformed into an irrevocable dislocation of the subject. Cherokee\u27s onomastic devalorization of the story\u27s characters and simulation of the human subject in the figure of the parrot Morgan create an indeterminacy that renders traditional conceptions of the self obsolete or irrelevant. Chatterton, whose point of departure is the infamous eighteenth-century forger Thomas Chatterton, uses the issue and example of pastiche to problematize the notion of the constitution of a subject in language and time. Both Cherokee and Chatterton take advantage of the subjective presuppositions of the detective genre in order to delineate the intricate problems of selfhood as a postmodern concern

Blood volume measurement with indocyanine green pulse spectrophotometry: dose and site of dye administration

(1) To determine the optimal administration site and dose of indocyanine green (ICG) for blood volume measurement using pulse spectrophotometry, (2) to assess the variation in repeated blood volume measurements for patients after subarachnoid hemorrhage and (3) to evaluate the safety and efficacy of this technique in patients who were treated for an intracranial aneurysm. Four repeated measurements of blood volume (BV) were performed in random order of bolus dose (10 mg or 25 mg ICG) and venous administration site (peripheral or central) in eight patients admitted for treatment of an intracranial aneurysm. Another five patients with subarachnoid hemorrhage underwent three repeated BV measurements with 25 mg ICG at the same administration site to assess the coefficient of variation. The mean +/- SD in BV was 4.38 +/- 0.88 l (n = 25) and 4.69 +/- 1.11 l (n = 26) for 10 mg and 25 mg ICG, respectively. The mean +/- SD in BV was 4.59 +/- 1.15 l (n = 26) and 4.48 +/- 0.86 l (n = 25) for central and peripheral administration, respectively. No significant difference was found. The coefficient of variance of BV measurement with 25 mg of ICG was 7.5% (95% CI: 3-12%). There is no significant difference between intravenous administration of either 10 or 25 mg ICG, and this can be injected through either a peripheral or central venous catheter. The 7.5% coefficient of variation in BV measurements determines the detectable differences using ICG pulse spectrophotometr

An English cover-up: masks, murders, and English cruelty in Goncourt, Lorrain, and Schwob

Fin-de-siècle writers from diverse disciplines were drawn to the seductive potential of masks and disguise; mask-wearing characters of indefinite identity, indeterminate gender, and insecure psychology proliferate in their texts. However, when characters are designated as English in such stories, they are also, and with remarkable frequency, associated with cruelty or murder: the mask-wielding murderers of Marcel Schwob’s ‘MM. Burke et Hare, Assassins’ carry out their crimes in Britain upon British victims; Edmond de Goncourt weaves his theatrical narrative around the mask-like demeanour of Lord Annandale in La Faustin; and Jean Lorrain’s malicious Lord Ethal exacerbates the Duc de Fréneuse’s perverse obsessions with masks in Monsieur de Phocas. This article explores this unexpected correlation, and examines the ways that English masks are used as narrative devices – at once to mould and play with national distinctions, and to reflect upon the psychological state of the French subject

Missing Persons: Cherokee's Parrot and Chatterton's Poet

This essay explores the problematic nature of selfhood in the detective genre as established by Edgar Allan Poe's "Murders in the Rue Morgue" (1841) and most recently reformulated in two metaphysical detective novels, Jean Echenoz's Cherokee (1983) and Peter Ackroyd's Chatterton (1987). Poe's detective Auguste Dupin is described as having a "Bi-Part Soul," which permits him to vacate himself in order to construct the narrative solution to a crime. This duality, in the postmodern detective novel, is transformed into an irrevocable dislocation of the subject. Cherokee's onomastic devalorization of the story's characters and simulation of the human subject in the figure of the parrot Morgan create an indeterminacy that renders traditional conceptions of the self obsolete or irrelevant. Chatterton , whose point of departure is the infamous eighteenth-century "forger" Thomas Chatterton, uses the issue and example of pastiche to problematize the notion of the constitution of a subject in language and time. Both Cherokee and Chatterton take advantage of the subjective presuppositions of the detective genre in order to delineate the intricate problems of selfhood as a postmodern concern

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease