Visie onderbouwend ecologisch onderzoek Milieu- en Natuurplanbureau : graadmeters, scenario's, modellen, meetnetten en data

Voor het waarborgen van de kwaliteit van (ruimtelijke) gegevens en indicatoren is centrale ontsluiting en gestandaardiseerde beschrijving van megadata noodzakelijk. Recent is een inventarisatie gemaakt van bestanden, die betrekking hebben op de beleidsdomeinen natuur, groene ruimte, recreatie en landbouw (beschikbaar via de website van Natuurplanbureau). Voor de beleidssectoren milieu en water zal een aanvullende inventarisatie nodig zij

Comparative study of total shoulder arthroplasty versus total shoulder surface replacement for glenohumeral osteoarthritis with minimum 2-year follow-up

BACKGROUND: Compared with total shoulder arthroplasty (TSA), total shoulder surface replacement (TSSR) may offer the advantage of preservation of bone stock and shorter surgical time, possibly at the expense of glenoid component positioning and increasing lateral glenohumeral offset. We hypothesized that in patients treated for osteoarthritis with a sufficient rotator cuff, TSA and TSSR patients have comparable functional outcome, glenoid component version, and lateral glenohumeral offset. METHODS: We conducted a retrospective cohort study with a minimum of 2 years of follow-up. Patients in the TSA and TSSR groups received a cemented, curved, keeled, all-poly glenoid component. A cemented anatomical humeral stem was used in TSA. TSSR involved a humeral surface replacement (all components from Tornier Inc., St Ismier, France). Patients were assessed for functional outcome. Radiographs were assessed for radiolucent lines. Glenoid component position and lateral glenohumeral offset were assessed using computed tomography images. RESULTS: After 29 and 34 months of mean follow-up, respectively, TSA (n = 29) and TSSR (n = 20) groups showed similar median adjusted Constant Scores (84% vs. 88%), Oxford Shoulder Scores (44 vs. 44), Disabilities of the Arm, Shoulder and Hand scores (22 vs. 15), and Dutch Simple Shoulder Test scores (10 vs. 11). Glenoid components showed similar radiolucent line counts (median, 0 vs. 0), similar anteversion angles (mean, 0 degrees vs. 2 degrees ), and similar preoperative to postoperative increases in lateral glenohumeral offset (mean, 4 vs. 5 mm). One intraoperative glenoid fracture occurred in the TSSR group. CONCLUSION: Short-term functional and radiographic outcomes were comparable for TSA and TSSR

Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin

Contains fulltext : 215648.pdf (publisher's version ) (Open Access)BACKGROUND: Three-weekly high-dose cisplatin (100 mg/m(2)) is considered the standard systemic regimen given concurrently with postoperative or definitive radiotherapy in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Concurrent chemoradiation (CRT) with high-dose cisplatin is associated with significant acute and late toxicities, including acute kidney injury (AKI). The aims of this study were to investigate the incidence of AKI in patients with LA-SCCHN during and after treatment with high-dose cisplatin-based CRT, to identify risk factors for cisplatin-induced AKI, and to describe the impact of AKI on long-term renal function and treatment outcomes. METHODS: This is a retrospective cohort study with measurements of renal function before CRT, weekly during CRT, every 1 or 2 days during hospitalizations, and 3 and 12 months after CRT in patients with LA-SCCHN. AKI was defined as increase in serum creatinine (sCr) of >/=1.5 times baseline or by >/=0.3 mg/dL (>/=26.5 mumol/L) using the Kidney Disease Improving Global Outcomes (KDIGO) classification. Logistic regression models were estimated to analyze renal function over time and to identify predictors for AKI. RESULTS: One hundred twenty-four patients completed all measurements. AKI was reported in 85 patients (69%) with 112 episodes of AKI. Sixty of 85 patients experienced 1 AKI episode; 20 patients experienced >/=2 AKI episodes. Ninety-three (83%) AKI episodes were stage 1, 13 (12%) were stage 2, and 6 (5%) AKI episodes were stage 3. Median follow-up time was 29 months (Interquartile Range, IQR 22-33). Hypertension (Odds Ratio, OR 2.7, 95% Confidence Interval, CI 1.1-6.6; p = 0.03), and chemotherapy-induced nausea and vomiting (CINV; OR 4.3, 95% CI 1.6-11.3; p = 0.003) were associated with AKI. In patients with AKI, renal function was significantly more impaired at 3 and 12 months post-treatment compared to patients without AKI. AKI did not have a negative impact on treatment outcomes. CONCLUSION: AKI occurred in 69% of patients with LA-SCCHN undergoing CRT with high-dose cisplatin. Long-term renal function was significantly more impaired in patients with AKI. Hypertension and CINV are significant risk factors. Optimizing prevention strategies for CINV are urgently needed

Screening for asymptomatic deep vein thrombosis in COVID-19 patients admitted to the medical ward: a cross-sectional study.

PURPOSE: Patients with COVID-19 have an increased risk for venous thrombo-embolism (VTE), especially pulmonary embolism. The exact prevalence of asymptomatic DVT is not known, as is the usefulness of screening for DVT in patients admitted to ward with COVID-19. We have studied the prevalence of asymptomatic DVT. METHODS: We performed a cross-sectional observational multi-center study at four university medical centers in The Netherlands. All adult patients admitted with COVID-19 to a medical ward were eligible for inclusion, including patients who were transferred back from the ICU to the ward. The study protocol consisted of weekly cross-sectional rounds of compression ultrasound. RESULTS: In total, 125 patients were included in the study. A significant proportion of patients (N = 34 (27%)) had developed a VTE during their admission for COVID-19 before the study ultrasound was performed. In most VTE cases (N = 27 (79%)) this concerned pulmonary embolism. A new asymptomatic DVT was found in 5 of 125 patients (4.0%; 95% CI 1.3-9.1%) (Table 2). Nine patients (7.2%; 95% CI 3.3-13.2%) developed a VTE (all PE) diagnosed within 28 days after the screening US was performed. CONCLUSION: We have shown a low prevalence (4%) of newly discovered asymptomatic DVT outside the ICU-setting in COVID-19 patients. Despite this low prevalence, nine patients developed PE (7%) within 28 days after ultrasound. This favors the hypothesis of local thrombus formation in the lungs. Based on our findings and literature, we do not recommend US-screening of asymptomatic patients with COVID-19 admitted to the ward

Correlação linear e espsacial entre a produtividade de feijão e a porosidade de um Latossolo Vermelho de Selvíria (MS) Linear and spatial correlation between common bean yield and porosity of a Red Latosol in Selvíria (MS), Brazil

A porosidade do solo exerce grande influência sobre o crescimento e desenvolvimento vegetal, uma vez que o crescimento das raízes, tal como a produtividade das culturas, é limitado pela profundidade que atingem. Portanto, o objetivo deste trabalho foi estudar a variabilidade espacial e as correlações lineares entre a produtividade de feijão e a porosidade do solo. No ano de 2004/2005, no município de Selvíria, MS, foram analisadas a produtividade de grãos de feijão (PG), cultivar IAC Carioca, irrigado, a macroporosidade (MA), a microporosidade (MI) e a porosidade total (PT) do solo em quatro profundidades: 1 (0,0-0,10); 2(0,10-0,20); 3(0,20-0,30) e 4(0,30-0,40 m), num Latossolo Vermelho distroférrico. As amostras de solo e planta foram coletadas em uma malha geoestatística com 75 pontos espaçados de 10 x 10 m, mais 60 pontos de quatro malhas de refinamento numa área de 50 x 150 m. Os atributos estudados, além de não terem variado aleatoriamente, apresentaram média e baixa variabilidades. Seguiram padrões espaciais bem definidos, com alcances entre 11,70 e 104,40 m. A correlação linear entre o atributo da planta e os do solo, em função do elevado número de observações, foi baixa. As de melhor correlação linear com a PG foram a MA1, MI1 e a PT3. Entretanto, do ponto de vista espacial, houve excelente correlação inversa entre a PG e a #PT2. Assim, nos sítios onde a #PT2 diminuiu (0,030-0,045 m³ m-3 ), a PG variou entre 2.173 e 3.529 kg ha-1. Já naqueles onde aumentou (0,045-0,076 m³ m-3 ), a PG ficou entre 1.630-2.173 kg ha-1. Assim, a porosidade total do solo, quando avaliada na camada de 0,10-0,20 m (#PT2), indicou a importância do contato raiz/solo e, de modo inverso, apresentou satisfatório indicador da qualidade física do solo estudado, quando destinado à produtividade de grãos de feijão irrigado.<br>Soil porosity influences plant development since root growth and crop yield are determined by the root depth. The objective of this study was to investigate the linear and spatial variability and correlations between common bean yield and soil porosity. The bean grain yield of the irrigated cultivar Carioca IAC was analyzed in the growing season 2004/2005, in Selviria-MS, as well as macroporosity (MA), microporosity (MI) and total porosity (TP), in a Dystroferric Red Latosol, at four depths: 1 (0.0-0.10 m), 2 (0.10-0.20 m), 3 (0.20-0.30 m) and 4 (0.30-0.40 m). Soil and plant data were collected in a geostatistical grid with 135 points spaced 10 m apart, covering an area of 50 x 150 m. The data of the studied attributes did not vary randomly and the values were intermediate to low. They followed well-defined spatial standards, reaching between 11.70-104.40 m. On the other hand, the linear correlation between the plant and soil attributes was low, due to the high number of observations. Grain yield had the best linear correlations with MA1b, MI1 and TP3. From the spatial point of view, the inverse correlation between PG and #TP2 was outstanding. At the sites where #TP2 diminished (0.030-0.045 m³ m-3 ) the yield varied from 2,173 to 3,529 kg ha-1 and where it increased (0.045-0.076 m³ m-3 ), the yield was between 1,630 and 2,173 kg ha-1. Therefore, the total soil porosity, evaluated in the 0.10-0.20 m layer (#TP2), indicated the importance of the contact root/soil and was in turn a satisfactory indicator of soil physical quality, with a view to the grain yield of irrigated common bean