Method for phase boundary structure control of laminated materials; destruction process investigations of nanostructured coatings with predetermined phase boundary texture

New surface texturing method by means of microplasma coating deposition with the following etching of the coating was shown and described. The method of step by step microplasma texturing was proposed to control the phase boundary of laminated materials. Micrographs of nanostructured inorganic non-metallic coating surface were obtained and analyzed before and after mechanical deformation. The nature of cracks formation and growth was investigated

Фармакологическая антиаритмическая терапия и модулированная кинезотерапия как первичная профилактика фибрилляции предсердий у больных метаболическим синдромом с преждевременными предсердными комплексами: проспективное исследование

Highlights. The results of primary prevention of atrial fibrillation by using antiarrhythmic drug therapy and modulated kinesitherapy in patients with metabolic syndrome with premature atrial complexes are presented.A significant decrease in the development of the disease was revealed in patients with metabolic syndrome and risk of atrial fibrillation within a year after the examination with the help of pharmacological antiarrhythmic therapy of atrial ectopia and modulated kinesotherapy as primary prevention in comparison with therapy aimed at correcting blood pressure, glucose and blood lipids.Aim. To assess the possibility of using antiarrhythmic drug therapy (DT) and modulated kinesitherapy (MK)  in patients with metabolic syndrome (MS) and premature atrial complexes (PAC) as the primary prevention of atrial fibrillation (AF).Methods. 426 MS patients with PAC aged from 58 to 72 years (mean 66.4±0.7 years) were included in the study. All patients had a high probability of developing primary AF within 1 year after the enrollment. Antiarrhythmic DT with class I–III  drugs was used as the primary prophylaxis of AF in 149 (34.97%) patients, MK  – in 121 (28.40%), the correction of blood pressure, glucose and blood lipids – in 156 (36.63%). All patients were followed up for one year and the end point of observation was the maintenance of sinus rhythm or AF registration.Results. Various clinical forms of AF were recorded in 26.45, 31.54% and 95.51% of patients with MS during primary prevention with the help of pharmacological AAT, UA and correction of its potentially modifiable components (arterial pressure, glucose and blood lipids), respectively, during the year after the examination.Conclusion. The use of both antiarrhythmic DT of I–III classes, and MК as a primary prophylaxis of AF in patients with MS with PAC and the risk of AF development within one year after the first examination made it possible to reduce the frequency of the arrhythmia by the correction of blood pressure, glucose and blood lipids.Основные положения. Представлены  результаты   первичной   профилактики   фибрилляции    предсердий  с  помощью медикаментозной  антиаритмической терапии и  модулированной   кинезотерапии у больных  метаболическим синдромом  с преждевременными  предсердными комплексами.У пациентов с  метаболическим синдромом   и  риском фибрилляции    предсердий  в  течение года после  обследования  выявлено   достоверно  значимое  снижение    развития заболевания при  использовании  фармакологической противоаритмической  терапии предсердной эктопии и  модулированной  кинезотерапии как первичной   профилактики   в сравнении  с терапией,  направленной  на коррекцию артериального давления,  содержания   глюкозы и липидов крови.Цель. Оценить   возможность  использования медикаментозной  антиаритмической терапии (ААТ) и модулированной  кинезотерапии (МК) у больных  метаболическим синдромом  (МС) с преждевременными    предсердными  комплексами в качестве первичной  профилактики  фибрилляции   предсердий (ФП).Материалы и методы. Наблюдали  426 пациентов    с  МС и  преждевременными   предсердными комплексами    в  возрасте  от  58 до  72 лет (в   среднем 66,4±0,7). У всех  больных отмечена  высокая  вероятность развития первичной   ФП в течение  года после включения   в исследование.  У 149 (34,97%) больных  для первичной  профилактики ФП использована  медикаментозная   ААТ препаратами  I–III классов, у  121 (28,40%) – МК, у  156 (36,63%) – коррекция   артериального  давления, содержания глюкозы и липидов крови. После включения в исследование всех пациентов наблюдали   в  течение года:  конечной   точкой  явилось  сохранение синусового ритма  или  регистрация ФП.Результаты. У 26,45, 31,54 и 95,51% пациентов   с МС при  первичной   профилактике   с помощью фармакологической ААТ, МК и  коррекции   его потенциально  модифицируемых  компонентов  (артериального давления,  содержания  глюкозы и липидов   крови)    соответственно в  течение  года после  обследования  зарегистрированы  различные  клинические формы ФП.Заключение. Применение   медикаментозной ААТ препаратами  I–III  классов и  МК в качестве первичной   профилактики   у  больных    МС с  преждевременными    предсердными   комплексами и  риском развития  ФП в  течение  года  после   обследования   позволило   в среднем    в три  раза снизить  частоту  возникновения  этой аритмии   в сравнении  с терапией, направленной на коррекцию   артериального давления, содержания глюкозы и липидов крови

Experiment K-6-23. Effect of spaceflight on levels and function of immune cells

Two different immunology experiments were performed on samples received from rats flown on Cosmos 1887. In the first experiment, rat bone marrow cells were examined in Moscow for their response to colony stimulating factor-M. In the second experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States where they were subjected to analysis on a flow cytometer. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor than did bone marrow cells from control rats. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and innate interleukin-2 receptor antigens than from control animals. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin than did equivalent cells from control rats

Long-term spectropolarimetric monitoring of the cool supergiant Betelgeuse

We report on a long-term monitoring of the cool supergiant Betelgeuse, using the NARVAL and ESPaDOnS high-resolution spectropolarimeters, respectively installed at Telescope Bernard Lyot (Pic du Midi Observatory, France) and at the Canada-France-Hawaii Telescope (Mauna Kea Observatory, Hawaii). The data set, constituted of circularly polarized (Stokes V) and intensity (Stokes I) spectra, was collected between 2010 and 2012. We investigate here the temporal evolution of magnetic field, convection and temperature at photospheric level, using simultaneous measurements of the longitudinal magnetic field component, the core emission of the Ca II infrared triplet, the line-depth ratio of selected photospheric lines and the radial velocity of the star.Comment: Proceedings of the Betelgeuse Workshop, Paris, 26-29 Nov 201

Demand analysis for competences in the field of information technologies from leading Russian companies

At the present stage of development of information technologies, the study of the need for qualified personnel is becoming more and more popular. At the same time, there is a problem of determining the compliance of specialists’ training level in the field of information technology with the requirements of employers. The article presents the results of a study of the demand for competencies in this field from leading Russian companies. The purpose of the study is to determine the generalized requirements for job seekers in the labor market and the formation of lists of key skills for each of the specialties (professional groups) in the field of information technology. An algorithmic solution is proposed for analyzing the demand for competencies and determining the most demanded skills for various areas. The proposed algorithm is implemented on the example of data on vacancies of the Yandex and VK Group companies, collected from open sources. Data collection was carried out by a modified method: the initial array was formed automatically using the ParseHub parser and corrected manually. The grouping of data was carried out according to the most demanded IT-specialties and according to the generalized formulations of the requirements for these specialties. The key skills of specialists in relevant IT-areas have been identified. The study uses a combination of theoretical and empirical methods. The above algorithm and the results of aggregating groups of vacancies for IT-specialists and their professional competencies demanded by employers can be used for a deeper analysis of demand in the labor market and taken into account when forming the competencies of students in information technology training programs

Features of using Cox regression in various instrumental environments

The presence of large amounts of data in information and analytical systems makes it necessary to study them using machine learning and artificial intelligence methods. These models require the definition of tuning parameters related to the specifics of the subject area. The article presents a Cox regression model to solve the problem of customer churn. Cox regression is recognized as a model with high accuracy of predictions in healthcare. Therefore, it is interesting to use the model in other industries. The paper presents the results and comparative analysis of calculations on the Cox model using three tools: Statistical Package for the Social Sciences, programming language R and Russian software – analytical platform Loginom. A distinctive feature of the developed probabilistic model is the determination of the risk of event occurrence in conditions of incomplete data, as well as the identification of indicators that have a significant impact on the degree of its manifestation

Dynamics of photogenerated charge carriers in TiO2 /MoO3, TiO2 /WO3 and TiO2 /V2O5 photocatalysts with mosaic structure

Titania is a widely used photocatalytic material possessing such advantages as low cost and high reactivity under the ultraviolet light illumination. However, the fast recombination of photoexcited charge carriers limits its application. Herein, we have synthesized original nanomaterials with mosaic structures that exhibited well-defined heterojunctions and new properties. Using SEM, XRD, EPR spectroscopy, photocatalytic measurements, and photoinduced pathphysiological activity of these photocatalysts, we studied the processes of charge carrier accumulation in TiO2 /MoO3, TiO2 /WO3, and TiO2 /V2 O5 under in situ UV illumination with emphasis on the charge exchange between energy levels of these nanosized semiconductors. It is shown that the accumulation of photoinduced charges occurs in two forms (i) filled electron traps corresponding to Ti4+ /Ti3+ levels and (ii) Mo5+ centers, both forms contributing to the photoinduced biocide activity of the samples. This work demonstrates that light exposure of heterostructure photocatalysts with mosaic surfaces produces different types of charge-trapping centers capable of interacting with molecular oxygen yielding peroxo species, which provide long-life light-induced ”self-cleaning” behavior. Such photoaccumulating materials open new opportunities in developing light-driven self-sterilization structures exhibiting a prolonged bactericidal effect up to 10 h after stopping light exposure. © 2020 by the authors. Licensee MDPI, Basel, Switzerland