Grundkurs Literatur aus Flandern und den Niederlanden II

Band 2 des Grundkurses Literatur aus Flandern und den Niederlanden präsentiert repräsentative Auszüge von zwölf Schlüsseltexten der niederländischsprachigen Literaturgeschichte sowohl auf Niederländisch als auch auf Deutsch. Dabei kann der Leser viele der großen Namen näher kennenlernen, von Hadewijch über Joost van den Vondel bis hin zu Multatuli, Harry Mulisch und Hugo Claus. Die breitgefächerte Textauswahl bietet darüber hinaus auch einen Einblick in unterschiedlichste Genres verschiedener historischer Epochen wie Lied, Epos, Drama, Lyrik und Roman

Rationale and design of the PRAETORIAN-COVID trial:A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease

There is much debate on the use of angiotensin receptor blockers (ARBs) in severe acute respiratory syndrome–coronavirus-2 (SARS-CoV-2)–infected patients. Although it has been suggested that ARBs might lead to a higher susceptibility and severity of SARS-CoV-2 infection, experimental data suggest that ARBs may reduce acute lung injury via blocking angiotensin-II–mediated pulmonary permeability, inflammation, and fibrosis. However, despite these hypotheses, specific studies on ARBs in SARS-CoV-2 patients are lacking. Methods: The PRAETORIAN-COVID trial is a multicenter, double-blind, placebo-controlled 1:1 randomized clinical trial in adult hospitalized SARS-CoV-2–infected patients (n = 651). The primary aim is to investigate the effect of the ARB valsartan compared to placebo on the composite end point of admission to an intensive care unit, mechanical ventilation, or death within 14 days of randomization. The active-treatment arm will receive valsartan in a dosage titrated to blood pressure up to a maximum of 160 mg bid, and the placebo arm will receive matching placebo. Treatment duration will be 14 days, or until the occurrence of the primary end point or until hospital discharge, if either of these occurs within 14 days. The trial is registered at clinicaltrials.gov (NCT04335786, 2020). The PRAETORIAN-COVID trial is a double-blind, placebo-controlled 1:1 randomized trial to assess the effect of valsartan compared to placebo on the occurrence of ICU admission, mechanical ventilation, and death in hospitalized SARS-CoV-2–infected patients. The results of this study might impact the treatment of SARS-CoV-2 patients globally

Om dit treurspel werkzaam en aangenaam in de oogen der aanschouweren te maaken.

This article describes the features and the function of the secondary plots in three Dutch tragedies, dating from the early eighteenth century: Lukas Rotgans' Scilla (1709), Lukas Schermer's Meleager en Atalante (1710) and Balthasar Huydecoper's Arzases (1722). It is shown that especially the poetical theories of French classicist writers (particularly d'Aubignac's La pratique du théâtre) have been influential. The secondary plots in these tragedies are studied under a threefold perspective. The first question to be answered is wether or not the secondary plots of Rotgans, Schermer and Huydecoper can be considered as vraisemblable, wether or not they are in accordance with the prescripts of probability. In the second place the intended emotional effect of the secondary plots upon the audience is regarded. Finally the interaction between main plot and secondary plot in Scilla, Meleager en Atalante and Arzases is being described