Charging and coagulation of dust in protoplanetary plasma environments

Combining a particle-particle, particle-cluster and cluster-cluster agglomeration model with an aggregate charging model, the coagulation and charging of dust particles in various plasma environments relevant for proto-planetary disks have been investigated. The results show that charged aggregates tend to grow by adding small particles and clusters to larger particles and clusters, leading to greater sizes and masses as compared to neutral aggregates, for the same number of monomers in the aggregate. In addition, aggregates coagulating in a Lorentzian plasma (containing a larger fraction of high-energy plasma particles) are more massive and larger than aggregates coagulating in a Maxwellian plasma, for the same plasma densities and characteristic temperature. Comparisons of the grain structure, utilizing the compactness factor, {\phi}{\sigma}, demonstrate that a Lorentzian plasma environment results in fluffier aggregates, with small {\phi}{\sigma}, which exhibit a narrow compactness factor distribution. Neutral aggregates are more compact, with larger {\phi}{\sigma}, and exhibit a larger variation in fluffiness. Measurement of the compactness factor of large populations of aggregates is shown to provide information on the disk parameters that were present during aggregation

Microscopic Analysis of Thermodynamic Parameters from 160 MeV/n - 160 GeV/n

Microscopic calculations of central collisions between heavy nuclei are used to study fragment production and the creation of collective flow. It is shown that the final phase space distributions are compatible with the expectations from a thermally equilibrated source, which in addition exhibits a collective transverse expansion. However, the microscopic analyses of the transient states in the reaction stages of highest density and during the expansion show that the system does not reach global equilibrium. Even if a considerable amount of equilibration is assumed, the connection of the measurable final state to the macroscopic parameters, e.g. the temperature, of the transient ''equilibrium'' state remains ambiguous.Comment: 13 pages, Latex, 8 postscript figures, Proceedings of the Winter Meeting in Nuclear Physics (1997), Bormio (Italy

Extracting the equation of state from a microscopic non-equilibrium model

We study the thermodynamic properties of infinite nuclear matter with the Ultrarelativistic Quantum Molecular Dynamics (URQMD), a semiclassical transport model, running in a box with periodic boundary conditions. It appears that the energy density rises faster than $T^4$ at high temperatures of $T\approx 200-300$~MeV. This indicates an increase in the number of degrees of freedom. Moreover, We have calculated direct photon production in Pb+Pb collisions at 160~GeV/u within this model. The direct photon slope from the microscopic calculation equals that from a hydrodynamical calculation without a phase transition in the equation of state of the photon source.Comment: Proceedings of the XIV International Conference on Particles and Nuclei (PANIC'96), 22-28 May 1996, Williamsburg, Virginia, USA, to be published by World Scientific Publ. Co. (3 pages

Signatures of dense hadronic matter in ultrarelativistic heavy ion reactions

The behavior of hadronic matter at high baryon densities is studied within Ultrarelativistic Quantum Molecular Dynamics (URQMD). Baryonic stopping is observed for Au+Au collisions from SIS up to SPS energies. The excitation function of flow shows strong sensitivities to the underlying equation of state (EOS), allowing for systematic studies of the EOS. Dilepton spectra are calculated with and without shifting the $\rho$ pole. Except for S+Au collisions our calculations reproduce the CERES data.Comment: Invited talk at RHIC-theory workshop at BNL july 8-1

Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects

SummaryThe recent Zika virus (ZIKV) outbreak in the Western hemisphere is associated with severe pathology in newborns, including microcephaly and brain damage. The mechanisms underlying these outcomes are under intense investigation. Here, we show that a 2015 ZIKV isolate replicates in multiple cell types, including primary human fetal neural progenitors (hNPs). In immortalized cells, ZIKV is cytopathic and grossly rearranges endoplasmic reticulum membranes similar to other flaviviruses. In hNPs, ZIKV infection has a partial cytopathic phase characterized by cell rounding, pyknosis, and activation of caspase 3. Despite notable cell death, ZIKV did not activate a cytokine response in hNPs. This lack of cell intrinsic immunity to ZIKV is consistent with our observation that virus replication persists in hNPs for at least 28 days. These findings, supported by published fetal neuropathology, establish a proof-of-concept that neural progenitors in the developing human fetus can be direct targets of detrimental ZIKV-induced pathology

Microscopic calculations of stopping and flow from 160AMeV to 160AGeV

The behavior of hadronic matter at high baryon densities is studied within Ultrarelativistic Quantum Molecular Dynamics (URQMD). Baryonic stopping is observed for Au+Au collisions from SIS up to SPS energies. The excitation function of flow shows strong sensitivities to the underlying equation of state (EOS), allowing for systematic studies of the EOS. Effects of a density dependent pole of the $\rho$-meson propagator on dilepton spectra are studied for different systems and centralities at CERN energies.Comment: Proceedings of the Quark Matter '96 Conference, Heidelberg, German

Microscopic Models for Ultrarelativistic Heavy Ion Collisions

In this paper, the concepts of microscopic transport theory are introduced and the features and shortcomings of the most commonly used ansatzes are discussed. In particular, the Ultrarelativistic Quantum Molecular Dynamics (UrQMD) transport model is described in great detail. Based on the same principles as QMD and RQMD, it incorporates a vastly extended collision term with full baryon-antibaryon symmetry, 55 baryon and 32 meson species. Isospin is explicitly treated for all hadrons. The range of applicability stretches from $E_{lab} 200$ GeV/nucleon, allowing for a consistent calculation of excitation functions from the intermediate energy domain up to ultrarelativistic energies. The main physics topics under discussion are stopping, particle production and collective flow.Comment: 129 pages, pagestyle changed using US letter (8.5x11 in) format. The whole paper (13 Mb ps file) could also be obtained from ftp://ftp.th.physik.uni-frankfurt.de/pub/urqmd/ppnp2.ps.g

Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis.

Acute flaccid myelitis (AFM) has caused motor paralysis in >560 children in the United States since 2014. The temporal association of enterovirus (EV) outbreaks with increases in AFM cases and reports of fever, respiratory, or gastrointestinal illness prior to AFM in >90% of cases suggest a role for infectious agents. Cerebrospinal fluid (CSF) from 14 AFM and 5 non-AFM patients with central nervous system (CNS) diseases in 2018 were investigated by viral-capture high-throughput sequencing (VirCapSeq-VERT system). These CSF and serum samples, as well as multiple controls, were tested for antibodies to human EVs using peptide microarrays. EV RNA was confirmed in CSF from only 1 adult AFM case and 1 non-AFM case. In contrast, antibodies to EV peptides were present in CSF of 11 of 14 AFM patients (79%), significantly higher than controls, including non-AFM patients (1/5 [20%]), children with Kawasaki disease (0/10), and adults with non-AFM CNS diseases (2/11 [18%]) (P = 0.023, 0.0001, and 0.0028, respectively). Six of 14 CSF samples (43%) and 8 of 11 sera (73%) from AFM patients were immunoreactive to an EV-D68-specific peptide, whereas the three control groups were not immunoreactive in either CSF (0/5, 0/10, and 0/11; P = 0.008, 0.0003, and 0.035, respectively) or sera (0/2, 0/8, and 0/5; P = 0.139, 0.002, and 0.009, respectively).IMPORTANCE The presence in cerebrospinal fluid of antibodies to EV peptides at higher levels than non-AFM controls supports the plausibility of a link between EV infection and AFM that warrants further investigation and has the potential to lead to strategies for diagnosis and prevention of disease