Mesenchymal stem cells in lymph node development and disease

Mebius, R.E. [Promotor

Mogelijkheden van indikken van melk op de boerderij = Possibilities of concentrating milk on-farm

This report described the possibilities of concentrating milk on the farm. It covers the technique to remove water from milk and all aspects as to quality, processing, legislation and economic feasibilit

Visible light tomography on RTP

A diagnostic for visible light tomography is being prepared for the Rijnhuizen Tokamak Project (RTP). Light emitted in the range of 200 to 1100 nm will be detected by five cameras positioned around the plasma in one poloidal plane. Each camera has 16 detector elements. The 80 channels are provided with parallel electronics with a bandwidth of 200 kHz. Imaging systems are used to collect the light on the detector elements. The resolution of this system is of the order of 1 cm. Optical filters in front of the detectors can select interesting wavelength ranges, such as spectral lines or a line-free part of the continuum radiatio

Effect of warm-up and precooling on pacing during a 15-km cycling time trial in the heat

PURPOSE:The best way to apply precooling for endurance exercise in the heat is still unclear. Therefore, we analyzed the effect of different preparation regimes on pacing during a 15-km cycling time trial in the heat.METHODS:Ten male subjects completed four 15-km time trials (30°C), preceded by different preparation regimes: 10 min cycling (WARM-UP), 30 min scalp cooling of which 10 min cycling (SC+WARM-UP), ice slurry ingestion (ICE), and ice slurry ingestion + 30 min scalp cooling (SC+ICE).RESULTS:No differences were observed in finish time and mean power output, although power output was lower for WARM-UP than for SC+ICE during km 13-14 (17±16 and 19±14 W, respectively) and for ICE during km 13 (16±16 W). Rectal temperature at the start of the time trial was lower for both ICE (~36.7°C) than both WARM-UP (~37.1°C) conditions and remained lower during the first part of the trial. Skin temperature and thermal sensation were lower at the start for SC+ICE.CONCLUSIONS:The preparation regime providing the lowest body heat content and sensation of coolness at the start (SC+ICE) was most beneficial for pacing during the latter stages of the time trial, although overall performance did not differ

SoftVoice improves speech recognition and reduces listening effort in cochlear implant users

Objectives:The ability to perceive soft speech by cochlear implant (CI) users is restricted in part by the inherent system noise produced by the speech processor, and in particular by the microphone(s). The algorithm "SoftVoice" (SV) was developed by Advanced Bionics to enhance the perception of soft speech by reducing the system noise in speech processors. The aim of this study was to examine the effects of SV on speech recognition and listening effort.Design:Seventeen adult Advanced Bionics CI recipients were recruited and tested in two sessions. The effect of SV on speech recognition was tested by determining the SRT in quiet using the Matrix test. Based on the individual subjects' SRTs, we investigated speech-recognition scores at fixed speech levels, namely SRT -5 dB, SRT +0 dB, SRT +5 dB, and SRT +10 dB, again in quiet and using the Matrix test. Listening effort was measured at each of these speech levels subjectively by using a rating scale, and objectively by determining pupil dilation with pupillometry. To verify whether SoftVoice had any negative effects on speech perception in noise, we determined the SRT in steady state, speech-weighted noise of 60 dBA.Results:Our results revealed a significant improvement of 2.0 dB on the SRT in quiet with SoftVoice. The average SRT in quiet without SoftVoice was 38 dBA. SoftVoice did not affect the SRT in steady state, speech-weighted noise of 60 dB. At an average speech level of 33 dBA (SRT -5 dB) and 38 dBA (SRT +0 dB) in quiet, significant improvements of 17% and 9% on speech-recognition scores were found with SoftVoice, respectively. At higher speech levels, SoftVoice did not significantly affect speech recognition. Pupillometry did not show significant effects of SoftVoice at any speech level. However, subjective ratings of listening effort indicated a decrease of listening effort with SoftVoice at a speech level of 33 dBA.Conclusions:We conclude that SoftVoice substantially improves recognition of soft speech and lowers subjective listening effort at low speech levels in quiet. However, no significant effect of SoftVoice was found on pupil dilation. As SRTs in noise were not statistically significantly affected by SoftVoice, we conclude that SoftVoice can be used in noisy listening conditions with little negative impact on speech recognition, if any. The increased power demands of the algorithm are considered to be negligible. It is expected that SoftVoice will reduce power consumption at low ambient sound levels. These results support the use of SoftVoice as a standard feature of Advanced Bionics CI fittings for everyday use.Disorders of the head and nec