The effects of a school-based physical activity intervention programme on children's executive control: The Health Oriented Pedagogical Project (HOPP)

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Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers

Background: The potential long-term developmental effects of prenatal methadone and buprenorphine exposure during pregnancy are still largely unknown. Aims: We investigated memory function in school-aged children of women enrolled in opioid maintenance therapy (OMT) during pregnancy. Study design: Prospective longitudinal cohort study. Subjects: Participants included 41 children (aged 9–11 years), 20 of which had histories of prenatal methadone or buprenorphine exposure. Outcome measures: Verbal and non-verbal memory function was assessed using four subtests from the Test of Memory and Learning - Second edition (TOMAL-2). Results: The OMT group scored lower on both the two non-verbal as well as the two verbal memory tasks, all p-values <.05. Group differences remained for three out of the four subtests after controlling for general IQ. Including maternal tobacco use during pregnancy increased the explanatory power of the model, R2 change of 0.07, p = .04. Conclusions: Children prenatally exposed to methadone or buprenorphine had significantly lower memory performance, however, this association may in part be explained by maternal tobacco use during pregnancy. Consequently, smoking cessation programs should be systematically integrated into opioid maintenance therapy programs for pregnant women.publishedVersio

Children born to women in opioid maintenance treatment: A longitudinal study of child behavioral problems and parenting stress

© 2022 Sarfi, Eikemo and Konijnenberg. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.In the wake of the “opioid epidemic”, there is considerable concern regarding potential harmful long-term effects of prenatal opioid exposure. Opioid misuse and addiction confer increased exposure to lifestyle stressors and health burdens. Accordingly, it is challenging to disentangle effects of prenatal opioid exposure per se from factors related to maternal stress. In this study, we followed 36 women enrolled in comprehensive opioid maintenance treatment (OMT) program and their children alongside 36 age-matched mother-child dyads from a community sample (COMP) from pregnancy until child-age 8 years. Across five sessions, we used a battery of well-established questionnaires to investigate trajectories of parenting stress and mental health symptoms as well as child behavior problems. The 8-year retention was relatively high (OMT: 72%, COMP: 67%), and the OMT sample remarkably stable and well-functioning, with minimal concomitant illicit drug use. Mixed effects regressions showed significantly different trajectories of child behavior problems (F = 3.8, p = 0.024) and parenting stress (F = 3.1, p = 0.016) in the two groups. Differences in experienced stress were largely explained by more distress specifically related to the parenting role in the OMT group (F = 9.7, p = 0.003). The OMT sample also reported higher psychological distress (F = 15.6, p < 0.001) than the comparison group, but notably few participants presented with problems that warranted clinical intervention. The results underscore the benefits of tailored follow-up of children prenatally exposed to opioids and their families beyond infancy and toddlerhood. Long-term direct effects of prenatal opioid exposure on behavior problems are likely modest, given an otherwise stable caregiving environment conducive to healthy development.publishedVersio

Vitamin B12 status in infancy and the effect of a vitamin B12 injection in infants with subclinical vitamin B12 deficiency: study protocol for a register-based randomised controlled trial

Introduction: Vitamin B12 (cobalamin) is crucial for optimal child development and growth, yet deficiency is common worldwide. The aim of this study is twofold; (1) to describe vitamin B12 status and the status of other micronutrients in Norwegian infants, and (2) in a randomised controlled trial (RCT), investigate the effect of vitamin B12 supplementation on neurodevelopment in infants with subclinical vitamin B12 deficiency. Methods and analysis: Infant blood samples, collected at public healthcare clinics, are analysed for plasma cobalamin levels. Infants with plasma cobalamin 6.5 µmol/L, are given an intramuscular injection of hydroxocobalamin (400 µg). The primary outcomes are cognitive, language and motor development assessed using the Bayley Scales of Infant and Toddler Development at 12 months of age. Ethics and dissemination: The study has been approved by the Regional Committee for Medical and Health Research Ethics (ref: 186505). Investigators who meet the Vancouver requirements will be eligible for authorship and be responsible for dissemination of study findings. Results will extend current knowledge on consequences of subclinical vitamin B12 deficiency during infancy and may inform future infant feeding recommendations.publishedVersio

Verbal and nonverbal theory of mind development in three- and four-year-olds

In the past three decades researchers have developed several tasks to measure theory of mind in young children. The current study administered one nonverbal theory of mind task and five verbal theory of mind tasks to a group of three-year-olds and a group of four-year-olds in order to investigate (1) how they perform on a nonverbal transfer task, (2) how the different verbal theory of mind tasks relate to each other, and (3) how the nonverbal transfer task relates to the verbal theory of mind tasks. The nonverbal theory of mind task was modified in a way that controlled children from passing this task by making three-way associations, using the behavioural rule that people look for objects where they last saw them, and using the situational cue of the actor disappearing from the scene to help predict the actor’s behaviour. Results showed that both three- and four-year-olds changed their looking behaviour based on the beliefs of the actor in the nonverbal transfer task. Results furthermore showed that the different verbal theory of mind tasks used in this study were related to each other, and that some of these tasks were more difficult to pass than others. In addition, this study found that the nonverbal transfer task did not correlate to any of the verbal theory of mind tasks. Based on the results of the theory of mind tasks administered, it was argued that three- and four-year-olds have already developed a theory of mind, but fail more difficult theory of mind tasks because of task difficulties not related to theory of mind, most likely information-processing demands

Methodological Issues in Assessing the Impact of Prenatal Drug Exposure

Prenatal drug exposure is a common public health concern that can result in perinatal complications, birth defects, and developmental disorders. The growing literature regarding the effects of prenatal exposure to specific drugs such as tobacco, alcohol, cocaine, and heroin is often conflicting and constantly changing. This review discusses several reasons why the effects of prenatal drug exposure are so difficult to determine, including variations in dose, timing, duration of exposure, polydrug use, unreliable measures of drug exposure, latent or “sleeper” effects, genetic factors, and socioenvironmental influences. In addition to providing research guidelines, this review also aims to help clinicians and policy makers to identify the strengths and weaknesses in studies investigating the effects of prenatal drug exposure. This knowledge may be used to make better informed decisions regarding the appropriate treatment for pregnant, drug-dependent women and their children

Affective decision-making in children prenatally exposed to opioids

Although opioid maintenance therapy (OMT) is currently recommended for pregnant opioid-dependent women, potential effects on children’s long-term development are still largely unknown. The current study assessed the long-term cognitive development of children born to women in OMT. Particularly, children’s decision-making performance was assessed with a child-friendly version of the Iowa Gambling Task. Using a prospective longitudinal design, a cohort of children was followed from birth to middle childhood. Data were collected in Norway between 2005 and 2017. Participants included 41 children (aged 9–11 years), 20 of whom had histories of prenatal methadone or buprenorphine exposure. Background data were collected from personal interviews and medical records in 2005–2006. Children’s affective decision-making was assessed in 2016–2017. Results showed no main effect of group on the net scores in the gambling task, F(1, 39) = 1.44, p = 0.24, η2 = 0.04, demonstrating no group differences in decision-making performance. A main effect of group was found on sensitivity to punishment, with children in the control group choosing the doors with the infrequent, but high punishment more often compared to children in the OMT group, F(1, 39) = 4.90, p = 0.03, η2 = 0.11. No main effect of group on decision-making speed was found, although results showed a significant interaction effect between group and gain, F(1, 8,194) = 4.09, p = 0.04, η2 = 0.001. Children prenatally exposed to opioids were found to have normal decision-making performance on an affective decision-making task and were able to consider future consequences when making decisions

Verbal and nonverbal memory in school-aged children born to opioid-dependent mothers

Background: The potential long-term developmental effects of prenatal methadone and buprenorphine exposure during pregnancy are still largely unknown. Aims: We investigated memory function in school-aged children of women enrolled in opioid maintenance therapy (OMT) during pregnancy. Study design: Prospective longitudinal cohort study. Subjects: Participants included 41 children (aged 9–11 years), 20 of which had histories of prenatal methadone or buprenorphine exposure. Outcome measures: Verbal and non-verbal memory function was assessed using four subtests from the Test of Memory and Learning - Second edition (TOMAL-2). Results: The OMT group scored lower on both the two non-verbal as well as the two verbal memory tasks, all p-values <.05. Group differences remained for three out of the four subtests after controlling for general IQ. Including maternal tobacco use during pregnancy increased the explanatory power of the model, R2 change of 0.07, p = .04. Conclusions: Children prenatally exposed to methadone or buprenorphine had significantly lower memory performance, however, this association may in part be explained by maternal tobacco use during pregnancy. Consequently, smoking cessation programs should be systematically integrated into opioid maintenance therapy programs for pregnant women