Semiconducting-to-metallic photoconductivity crossover and temperature-dependent Drude weight in graphene

We investigated the transient photoconductivity of graphene at various gate-tuned carrier densities by optical-pump terahertz-probe spectroscopy. We demonstrated that graphene exhibits semiconducting positive photoconductivity near zero carrier density, which crosses over to metallic negative photoconductivity at high carrier density. Our observations are accounted for by considering the interplay between photo-induced changes of both the Drude weight and the carrier scattering rate. Notably, we observed multiple sign changes in the temporal photoconductivity dynamics at low carrier density. This behavior reflects the non-monotonic temperature dependence of the Drude weight, a unique property of massless Dirac fermions

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.

DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein degradation, is phosphorylated by DNA-PK and recruited to DNA double-strand break sites to regulate DNA damage repair. However, it is not clear whether VCP is involved in DNA-PKcs (DNA-PK catalytic subunit) degradation or whether it regulates the radiosensitivity of glioblastoma. Our data demonstrated that DNA-PKcs was ubiquitinated and bound to VCP. VCP knockdown resulted in the accumulation of the DNA-PKcs protein in glioblastoma cells, and the proteasome inhibitor MG132 synergised this increase. As expected, this increase promoted the efficiency of DNA repair in several glioblastoma cell lines; in turn, this enhanced activity decreased the radiation sensitivity and prolonged the survival fraction of glioblastoma cells in vitro. Moreover, the VCP knockdown in glioblastoma cells reduced the survival time of the xenografted mice with radiation treatment relative to the control xenografted glioblastoma mice. In addition, the VCP protein was also downregulated in ~25% of GBM tissues from patients (WHO, grade IV astrocytoma), and the VCP protein level was correlated with patient survival (R(2)=0.5222, P<0.05). These findings demonstrated that VCP regulates DNA-PKcs degradation and increases the sensitivity of GBM cells to radiation

Gamma-ray emission from the globular clusters Liller 1, M80, NGC 6139, NGC 6541, NGC 6624, and NGC 6752

Globular clusters (GCs) are emerging as a new class of gamma-ray emitters, thanks to the data obtained from the Fermi Gamma-ray Space Telescope. By now, eight GCs are known to emit gamma-rays at energies >100~MeV. Based on the stellar encounter rate of the GCs, we identify potential gamma-ray emitting GCs out of all known GCs that have not been studied in details before. In this paper, we report the discovery of a number of new gamma-ray GCs: Liller 1, NGC 6624, and NGC 6752, and evidence for gamma-ray emission from M80, NGC 6139, and NGC 6541, in which gamma-rays were found within the GC tidal radius. With one of the highest metallicity among all GCs in the Milky Way, the gamma-ray luminosity of Liller 1 is found to be the highest of all known gamma-ray GCs. In addition, we confirm a previous report of significant gamma-ray emitting region next to NGC 6441. We briefly discuss the observed offset of gamma-rays from some GC cores. The increasing number of known gamma-ray GCs at distances out to ~10 kpc is important for us to understand the gamma-ray emitting mechanism and provides an alternative probe to the underlying millisecond pulsar populations of the GCs.Comment: 22 pages, 7 figures, 2 tables; ApJ, in pres

Lattice vibrations and structural instability in Cesium near the cubic to tetragonal transition

Under pressure cesium undergoes a transition from a high-pressure fcc phase (Cs-II) to a collapsed fcc phase (Cs-III) near 4.2GPa. At 4.4GPa there follows a transition to the tetragonal Cs-IV phase. In order to investigate the lattice vibrations in the fcc phase and seek a possible dynamical instability of the lattice, the phonon spectra of fcc-Cs at volumes near the III-IV transition are calculated using Savrasov's density functional linear-response LMTO method. Compared with quasiharmonic model calculations including non-central interatomic forces up to second neighbours, at the volume $V/V_0= 0.44$ ($V_0$ is the experimental volume of bcc-Cs with $a_0$=6.048{\AA}), the linear-response calculations show soft intermediate wavelength $T_{[1\bar{1}0]}[{\xi}{\xi}0]$ phonons. Similar softening is also observed for short wavelength $L[\xi\xi\xi]$ and $L[00\xi]$ phonons and intermediate wavelength $L[\xi\xi\xi]$ phonons. The Born-von K\'{a}rm\'{a}n analysis of dispersion curves indicates that the interplanar force constants exhibit oscillating behaviours against plane spacing $n$ and the large softening of intermediate wavelength $T_{[1\bar{1}0]}[{\xi}{\xi}0]$ phonons results from a negative (110)-interplanar force-constant $\Phi_{n=2}$. The frequencies of the $T_{[1\bar{1}0]}[{\xi}{\xi}0]$ phonons with $\xi$ around 1/3 become imaginary and the fcc structure becomes dynamically unstable for volumes below $0.41V_0$. It is suggested that superstructures corresponding to the $\mathbf{q}{\neq}0$ soft mode should be present as a precursor of tetragonal Cs-IV structure.Comment: 12 pages, 5 figure

Double-peaked Narrow Emission-line Galaxies in LAMOST Survey

We outline a full-scale search for galaxies exhibiting double-peaked profiles of promi- nent narrow emission lines, motivated by the prospect of finding objects related to merging galaxies, and even dual active galactic nuclei candidates as by-product, from the Large Sky Area Multi-object Fiber Spectroscopic Telescope (LAMOST) Data Re- lease 4. We assemble a large sample of 325 candidates with double-peaked or strong asymmetric narrow emission lines, with 33 objects therein appearing optically resolved dual-cored structures, close companions or signs of recent interaction on the Sloan Dig- ital Sky Survey images. A candidate from LAMOST (J074810.95+281349.2) is also stressed here based on the kinematic and spatial decompositions of the double-peaked narrow emission line target, with analysis from the cross-referenced Mapping Nearby Galaxies at the Apache Point Observatory (MaNGA) survey datacube. MaNGA en- ables us to constrain the origin of double peaks for these sources, and with the IFU data we infer that the most promising origin of double-peaked profiles for LAMOST J074810.95+281349.2 is the `Rotation Dominated + Disturbance' structure.Comment: 13 pages, 9 figures, accepted by MNRA

Multiport Bidirectional SRM Drives for Solar-Assisted Hybrid Electric Bus Powertrain With Flexible Driving and Self-Charging Functions

The hybrid electric bus (HEB) presents an emerging solution to exhaust gas emissions in urban transport. This paper proposes a multiport bidirectional switched reluctance motor (SRM) drive for solar-assisted HEB (SHEB) powertrain, which not only improves the motoring performance, but also achieves flexible charging functions. To extend the driving miles and achieve self-charging ability, photovoltaic (PV) panels are installed on the bus to decrease the reliance on fuelsbatteries and charging stations. A bidirectional front-end circuit with a PV-fed circuit is designed to integrate electrical components into one converter. Six driving and five charging modes are achieved. The dc voltage is boosted by the battery in generator control unit (GCU) driving mode and by the charge capacitor in battery driving mode, where the torque capability is improved. Usually, an extra converter is needed to achieve battery charging. In this paper, the battery can be directly charged by the demagnetization current in GCU or PV driving mode, and can be quickly charged by the PV panels and GCUAC grids at SHEB standstill conditions, by utilizing the traction motor windings and integrated converter circuit, without external charging converters. Experiments on a three-phase 128 SRM confirm the effectiveness of the proposed drive and control scheme

A framework for 3D vessel analysis using whole slide images of liver tissue sections

Three-dimensional (3D) high resolution microscopic images have high potential for improving the understanding of both normal and disease processes where structural changes or spatial relationship of disease features are significant. In this paper, we develop a complete framework applicable to 3D pathology analytical imaging, with an application to whole slide images of sequential liver slices for 3D vessel structure analysis. The analysis workflow consists of image registration, segmentation, vessel cross-section association, interpolation, and volumetric rendering. To identify biologically-meaningful correspondence across adjacent slides, we formulate a similarity function for four association cases. The optimal solution is then obtained by constrained Integer Programming. We quantitatively and qualitatively compare our vessel reconstruction results with human annotations. Validation results indicate a satisfactory concordance as measured both by region-based and distance-based metrics. These results demonstrate a promising 3D vessel analysis framework for whole slide images of liver tissue sections