Vogt-Koyanagi-Harada disease in pregnancy: Case report and review of 32 patients in the literature

A 30-year-old woman in 31 weeks of pregnancy with metamorphopsia and headache was diagnosed Vogt-Koyanagi-Harada disease. She underwent steroid pulse therapy and oral prednisolone 20 mg daily for 3 weeks until complete resolution of serous retinal detachment monitored by optical coherence tomography. Oral prednisolone was tapered and discontinued until uneventful delivery

Dietary counseling for hyperuricemia

In Japan, hyperuricemia is on the rise. The guideline for the management of hyperuricemia and gout recommends lifestyle changes before beginning drug therapy. This study aimed to evaluate the effectiveness of dietary counseling following the guideline. Thirty-three subjects (24 men and 9 women) with asymptomatic hyperuricemia underwent dietary counseling for 6 months based on the following recommendations : (1) prevent excessive purine intake, (2) prevent excessive fructose intake, (3) limit alcohol drinking, and (4) drink sufficient water. Obese subjects were counseled on adequate energy intake. Blood sampling, anthropometric measurements, dietary surveys, and 24-h urine collection were performed at baseline and at 6 months. Serum uric acid (S-UA) levels were significantly lower at 6 months compared to baseline. Water intake and urine volume were considerably higher at 6 months than at baseline. When compared to baseline, urine UA (U-UA) levels were significantly lower, and renal fractional excretion of UA (FEUA) was significantly higher at 6 months. Changes in renal function (serum creatinine, estimated glomerular filtration rate, and FEUA) were significantly associated with ΔS-UA level. In this study, S-UA level was significantly decreased by dietary counseling in line with the guideline. This study illustrates the effectiveness of dietary counseling for asymptomatic hyperuricemia

Trends in cause specific mortality across occupations in Japanese men of working age during period of economic stagnation, 1980-2005: retrospective cohort study

Objective To assess the temporal trends in occupation specific all causes and cause specific mortality in Japan between 1980 and 2005

Enhancement of astaxanthin production in Xanthophyllomyces dendrorhous by efficient method for the complete deletion of genes

Additional file 1. DNA seuence of primers used in this study

Papillo-Choledochectomy in the Operative Management of Mucosal Neoplasms of the Periampullary Region

Two patients with mucosal cancer of the periampullary region were treated with papillocholedochectomy, which entails removal of the papilla of Vater and the whole length of the common bile duct. The neoplasm is dissected out through the plane between the duodenal circular and longitudinal muscles, deep to the sphincter of Oddi and the fibromuscular layer of the bile duct. Pathological examination showed that cancer was confined to the mucosal layer without stromal invasion, and that the operation achieved radical cure. For mucosal cancer, papillo-choledochectomy is an alternative to pancreatoduodenectomy, provided that repeated frozen-section studies confirm the completeness of excision

チョメイナ カンガイ ハツイク オ シメシタ カンケッカンシュ ノ 1レイ

Giant hemangiomas of the liver with the diameter of more then 10 cm are likely to grow rapidly with bleeding in tumor and concur a terrible complication such as heavy bleeding caused by tumor rupture. We experienced a case of giant hemangioma of the liver with a pronounced extrahepatic growth. A 33-year-old woman consulted a doctor because of common cold and was pointed out having hepatomegaly. She was admitted to the hospital for further examination. Abdominal ultrasonography showed a heterogenous high echoic tumor with even surface lying ventral to the gallbladder from the margin inferior hepatis. Abdominal CT scan showed a low density tumor which growed from S4, 5 and 6 of the liver to extrahepatic area. The tumor was confirmed to show low intensity on T1-weighted images and remarkable high intensity on T2-weighted images on a magneticresonance imaging scan and had strong contract effect from the edge by a contract medium. It showed cotton wool like appearance on an angiography. It was diagnosed as hemangioma of the liver and a partial hepatic resection was conducted. The resected tumor was rubiginous, spongy, 11×5.5×7.5 cm in size and 660g in weight. Histopathologically, it was diagnosed as cavernous hemangioma