Co-designing MOOCs with CoDe-Graph

As MOOCs have become a standard format of online learning, it is increasingly important to design courses that ft the needs and contexts of the targeted learners. One way to do so is by actively designing with the subject experts, instructors, and other stakeholders. Within the context of designing MOOCs for disadvantaged groups in Southeast Asia, we explore the three-phase process of co-design. We present a graphical modeling language, CoDe-Graph, which can be used to facilitate the co-design process. We examine how diverse groups of experts provide feedback on design elements and create a com mon understanding using shared artifacts. Four case studies illustrate how the tool can be used by co-design teams to create and visualize custom MOOC designs

Corporate social responsibility and circular economy from the perspective of consumers: A cross-cultural analysis in the cosmetic industry

Corporate social responsibility (CSR) and circular economy (CE) have assumed considerable importance in the efforts for sustainable development. However, some consumers do not positively respond to CSR and CE activities, and few studies have analyzed the consumers' perspective about the topics. This study investigates consumer knowledge and perception about CSR and CE and their willingness to pay (WTP) for products from companies that follow these concepts, examining differences according to demographic characteristics. We carried out a survey with 302 Brazilian and Italian consumers of cosmetic products. Our results show that most consumers have a low understanding of CSR and CE and a low perception of the socio-environmental initiatives of companies that follow CSR and CE concepts. Nevertheless, most consumers show WTP for products from companies that follow these concepts. We identified demographic variables that allowed us to relate the profile of consumers with their knowledge about CSR and CE and their WTP. We provide insights for companies and policymakers in advancing toward CSR and CE

Inferring metabolic mechanisms of interaction within a defined gut microbiota

The diversity and number of species present within microbial communities create the potential for a multitude of interspecies metabolic interactions. Here, we develop, apply, and experimentally test a framework for inferring metabolic mechanisms associated with interspecies interactions. We perform pairwise growth and metabolome profiling of co-cultures of strains from a model mouse microbiota. We then apply our framework to dissect emergent metabolic behaviors that occur in co-culture. Based on one of the inferences from this framework, we identify and interrogate an amino acid cross-feeding interaction and validate that the proposed interaction leads to a growth benefit in vitro. Our results reveal the type and extent of emergent metabolic behavior in microbial communities composed of gut microbes. We focus on growth-modulating interactions, but the framework can be applied to interspecies interactions that modulate any phenotype of interest within microbial communities

Redesign in the textile industry: Proposal of a methodology for the insertion of circular thinking in product development processes

Despite the growing attention toward negative environmental impacts generated by the textile industry, companies face challenges in achieving sustainable and circular economy (CE) transition. The literature has so far lacked a systematic effort to analyze how textile companies can insert CE elements in their new product development process (NPD), especially regarding the proposition of methodologies that can better assist the companies in this regard. This study aims to identify good green innovation and CE practices in NPD adopted by textile companies and propose a methodology from Design Thinking (DT) to insert circular thinking in NPD. To that end, we conducted the research in two steps: (i) narrative bibliographic review and (ii) field research. The bibliographic review was conducted in the “Web of Science”, “Scopus”, and “Scielo” databases. The field research was executed with four textile companies. Our results show that companies tend to consider socio-environmental aspects at different stages of the development of new products. However, there is opportunities for improvement, especially through the use of ideas from DT. The proposed methodology is composed of two main cycles: the design cycle (DT stages) and the consumption cycle (subsequent stages). It encompasses the five main stages of the DT and the three macro phases of NPD of the textile industry. The ideas coming from the DT, especially creativity, focus on the user and stakeholder integration, assist in the development of innovative and circular solutions. The methodology presents how companies can work on reuse, recycling, and manufacturing issues, so that CE occurs. In the end, we evaluated, together with experts, the applicability of the proposed use of ideas of DT in practical cases. The research advances the discussions on NPD in the textile sector, especially on its potential to contribute to the transition to CE. It explores how DT assists in inserting circular thinking into the NPD and presents alternatives for companies to develop circular products and insert green innovations in their NPD

A novel mouse model of Campylobacter jejuni enteropathy and diarrhea

Campylobacter infections are among the leading bacterial causes of diarrhea and of ‘environmental enteropathy’ (EE) and growth failure worldwide. However, the lack of an inexpensive small animal model of enteric disease with Campylobacter has been a major limitation for understanding its pathogenesis, interventions or vaccine development. We describe a robust standard mouse model that can exhibit reproducible bloody diarrhea or growth failure, depending on the zinc or protein deficient diet and on antibiotic alteration of normal microbiota prior to infection. Zinc deficiency and the use of antibiotics create a niche for Campylobacter infection to establish by narrowing the metabolic flexibility of these mice for pathogen clearance and by promoting intestinal and systemic inflammation. Several biomarkers and intestinal pathology in this model also mimic those seen in human disease. This model provides a novel tool to test specific hypotheses regarding disease pathogenesis as well as vaccine development that is currently in progress

The structural history and mineralization controls of the world-class Geita Hill gold deposit, Geita Greenstone Belt, Tanzania

The Geita Hill gold deposit is located in the Archean Geita Greenstone Belt and is one of the largest gold deposits in East Africa. The Geita Greenstone Belt experienced a complex deformation and intrusive history that is well illustrated and preserved in and around the Geita Hill gold deposit. Deformation involved early stages of ductile shearing and folding (D1 to D5), during which episodic emplacement of large diorite intrusive complexes, sills, and dykes occurred. These ductile deformation phases were followed by the development of brittle-ductile shear zones and faults (D6 to D8). The last stages of deformation were accompanied by voluminous felsic magmatism involving the intrusion of felsic porphyry dykes, within the greenstone belt, and the emplacement of large granitic bodies now forming the margins of the greenstone belt. Early, folded lamprophyre dykes, and later lamprophyre dykes, crosscutting the folded sequence are common, although volumetrically insignificant. The gold deposit formed late during the tectonic history of the greenstone belt, post-dating ductile deformation and synchronous with the development of brittle-ductile shear zones that overprinted earlier structural elements. The main mineralizing process involved sulfide replacement of magnetite-rich layers in ironstone and locally the replacement of ferromagnesian phases and magnetite in the diorite intrusions. The intersection between the brittle-ductile (D6) Geita Hill Shear Zone and different structural elements of ductile origin (e.g., fold hinges), and the contact between banded ironstone and folded diorite dykes and sills provided the optimal sites for gold mineralization