Modelling of survival of patients with colon adenocarcinoma based on multivariable analysis of the state of cancer cell nuclear apparatus

The aim: The creation of a mathematical model of survival in patients with colon adenocarcinoma based on multivariable analysis of the state of cancer cell nuclear apparatus. Patients and Methods: The study was performed on 141 samples of biopsy materials or material obtained during surgical treatment of the patients with colon adenocarcinoma or benign colon neoplasms with the use of histological, morphometric, densitometric, immunohistochemical and mathematical methods. Results: It has been shown that each discrete pattern of the state of adenocarcinoma cell nuclei (quantity of DNA, the number and volume of nuclear organizer regions, expression rates of Ki-67, Bcl-2 and p53) is prognostically invalid in the case of its separate use. Combination of these characteristics significantly enhances prognostic validity of the survival model. Based on equation of Cox proportional hazards, survival model of good quality for the patients with moderately and poorly differentiated adenocarcinoma and increased average DNA content in tumor cell nuclei has been created. Conclusion: The proposed survival model for colon adenocarcinoma demonstrates the quality twice superior to the model based on the use of tumor grade only (G) which in fact is presently used as a sole common independent histological criterion of prognosis

Nanosized superparamagnetic precipitates in cobalt-doped ZnO

The existence of semiconductors exhibiting long-range ferromagnetic ordering at room temperature still is controversial. One particularly important issue is the presence of secondary magnetic phases such as clusters, segregations, etc... These are often tedious to detect, leading to contradictory interpretations. We show that in our cobalt doped ZnO films grown homoepitaxially on single crystalline ZnO substrates the magnetism unambiguously stems from metallic cobalt nano-inclusions. The magnetic behavior was investigated by SQUID magnetometry, x-ray magnetic circular dichroism, and AC susceptibility measurements. The results were correlated to a detailed microstructural analysis based on high resolution x-ray diffraction, transmission electron microscopy, and electron-spectroscopic imaging. No evidence for carrier mediated ferromagnetic exchange between diluted cobalt moments was found. In contrast, the combined data provide clear evidence that the observed room temperature ferromagnetic-like behavior originates from nanometer sized superparamagnetic metallic cobalt precipitates.Comment: 20 pages, 6 figures; details about background subtraction added to section III. (XMCD

Changes in the middle and upper atmosphere parameters during the January 2013 sudden stratospheric warming

We present the results of complex obser-vations of various parameters of the middle and upper atmosphere over Siberia in December 2012 – January 2013, during a major sudden stratospheric warming (SSW) event. We analyze variations in ozone concentration from microwave measurements, in stratosphere and lower mesosphere temperatures from lidar and satellite measurements, in the F2-layer critical frequency (foF2), in the total electron content (TEC), as well as in the ratio of concentrations of atomic oxygen to molecular nitrogen (O/N2) in the thermosphere. To interpret the observed disturbances in the upper atmosphere, the experimental measurements are compared with the results of model calculations obtained with the Global Self-consistent Model of Thermosphere—Ionosphere—Protonosphere (GSM TIP). The response of the upper atmosphere to the SSW event is shown to be a decrease in foF2 and TEC during the evolution of the warming event and a prolonged increase in O/N2, foF2, and TEC after the SSW maximum. For the first time, we observe the relation between the increase in stratospheric ozone, thermospheric O/N2, and ionospheric electron density for a fairly long time (up to 20 days) after the SSW maximum at midlatitudes

MODELLING OF SURVIVAL OF PATIENTS WITH COLON ADENOCARCINOMA BASED ON MULTIVARIABLE ANALYSIS OF THE STATE OF CANCER CELL NUCLEAR APPARATUS

The aim: The creation of a mathematical model of survival in patients with colon adenocarcinoma based on multivariable analysis of the state of cancer cell nuclear apparatus. Patients and Methods: The study was performed on 141 samples of biopsy materials or material obtained during surgical treatment of the patients with colon adenocarcinoma or benign colon neoplasms with the use of histological, morphometric, densitometric, immunohistochemical and mathematical methods. Results: It has been shown that each discrete pattern of the state of adenocarcinoma cell nuclei (quantity of DNA, the number and volume of nuclear organizer regions, expression rates of Ki-67, Bcl-2 and p53) is prognostically invalid in the case of its separate use. Combination of these characteristics significantly enhances prognostic validity of the survival model. Based on equation of Cox proportional hazards, survival model of good quality for the patients with moderately and poorly differentiated adenocarcinoma and increased average DNA content in tumor cell nuclei has been created. Conclusion: The proposed survival model for colon adenocarcinoma demonstrates the quality twice superior to the model based on the use of tumor grade only (G) which in fact is presently used as a sole common independent histological criterion of prognosis

Selfie in student environment: from selfie addiction awareness to everyday practices study

The relevance of this article is to study such a social phenomenon as selfie. With the development of society, the life of each person changes, the practices of his/her behavior change, as well as new ones arise under the influence of emerging social phenomena. The article considers the views of students about selfies; it defines types of selfies in different categories. It is revealed that preference is given to individual selfies, on holidays or events that are important for the author personally, in order to capture their emotions. It is revealed that almost half of students have a low degree of activity in accounts and is expressed in monitoring the publications of other users

Selfie in student environment: From selfie addiction awareness to everyday practices study [Selfie en el entorno estudiantil: De la conciencia de adicción al selfie, hasta el estudio de prácticas cotidianas]

The relevance of this article is to study such a social phenomenon as selfie. With the development of society, the life of each person changes, the practices of his/her behavior change, as well as new ones arise under the influence of emerging social phenomena. The article considers the views of students about selfies; it defines types of selfies in different categories. It is revealed that preference is given to individual selfies, on holidays or events that are important for the author personally, in order to capture their emotions. It is revealed that almost half of students have a low degree of activity in accounts and is expressed in monitoring the publications of other users. © 2020, Universidad del Zulia. All rights reserved

The Oryza sativa no pollen (Osnop) gene plays a role in male gametophyte development and most likely encodes a C2-GRAM domain-containing protein

10.1007/s11103-005-2859-xPlant Molecular Biology576835-853PMBI