Analytic Evidence for Continuous Self Similarity of the Critical Merger Solution

The double cone, a cone over a product of a pair of spheres, is known to play a role in the black-hole black-string phase diagram, and like all cones it is continuously self similar (CSS). Its zero modes spectrum (in a certain sector) is determined in detail, and it implies that the double cone is a co-dimension 1 attractor in the space of those perturbations which are smooth at the tip. This is interpreted as strong evidence for the double cone being the critical merger solution. For the non-symmetry-breaking perturbations we proceed to perform a fully non-linear analysis of the dynamical system. The scaling symmetry is used to reduce the dynamical system from a 3d phase space to 2d, and obtain the qualitative form of the phase space, including a non-perturbative confirmation of the existence of the "smoothed cone".Comment: 25 pages, 4 figure

Dynamical vs. Auxiliary Fields in Gravitational Waves around a Black Hole

The auxiliary/dynamic decoupling method of hep-th/0609001 applies to perturbations of any co-homogeneity 1 background (such as a spherically symmetric space-time or a homogeneous cosmology). Here it is applied to compute the perturbations around a Schwarzschild black hole in an arbitrary dimension. The method provides a clear insight for the existence of master equations. The computation is straightforward, coincides with previous results of Regge-Wheeler, Zerilli and Kodama-Ishibashi but does not require any ingenuity in either the definition of variables or in fixing the gauge. We note that the method's emergent master fields are canonically conjugate to the standard ones. In addition, our action approach yields the auxiliary sectors.Comment: 26 page

High and Low Dimensions in The Black Hole Negative Mode

The negative mode of the Schwarzschild black hole is central to Euclidean quantum gravity around hot flat space and for the Gregory-Laflamme black string instability. We analyze the eigenvalue as a function of space-time dimension by constructing two perturbative expansions: one for large d and the other for small d-3, and determining as many coefficients as we are able to compute analytically. Joining the two expansions we obtain an interpolating rational function accurate to better than 2% through the whole range of dimensions including d=4.Comment: 17 pages, 4 figures. v2: added reference. v3: published versio

Matched Asymptotic Expansion for Caged Black Holes - Regularization of the Post-Newtonian Order

The "dialogue of multipoles" matched asymptotic expansion for small black holes in the presence of compact dimensions is extended to the Post-Newtonian order for arbitrary dimensions. Divergences are identified and are regularized through the matching constants, a method valid to all orders and known as Hadamard's partie finie. It is closely related to "subtraction of self-interaction" and shows similarities with the regularization of quantum field theories. The black hole's mass and tension (and the "black hole Archimedes effect") are obtained explicitly at this order, and a Newtonian derivation for the leading term in the tension is demonstrated. Implications for the phase diagram are analyzed, finding agreement with numerical results and extrapolation shows hints for Sorkin's critical dimension - a dimension where the transition turns second order.Comment: 28 pages, 5 figures. v2:published versio

On Black-Brane Instability In an Arbitrary Dimension

The black-hole black-string system is known to exhibit critical dimensions and therefore it is interesting to vary the spacetime dimension $D$, treating it as a parameter of the system. We derive the large $D$ asymptotics of the critical, i.e. marginally stable, string following an earlier numerical analysis. For a background with an arbitrary compactification manifold we give an expression for the critical mass of a corresponding black brane. This expression is completely explicit for ${\bf T}^n$, the $n$ dimensional torus of an arbitrary shape. An indication is given that by employing a higher dimensional torus, rather than a single compact dimension, the total critical dimension above which the nature of the black-brane black-hole phase transition changes from sudden to smooth could be as low as $D\leq 11$.Comment: 1+14 pages, 2 eps figures. Replaced with the published versio

Cascade of Gregory-Laflamme Transitions and U(1) Breakdown in Super Yang-Mills

In this paper we consider black p-branes on square torus. We find an indication of a cascade of Gregory-Laflamme transitions between black p-brane and (p-1)-brane. Through AdS/CFT correspondence, these transitions are related to the breakdown of the U(1) symmetry in super Yang-Mills on torus. We argue a relationship between the cascade and recent Monte-Carlo data.Comment: 15 pages, 3 figures, LaTeX, v2: comments and references added, v3: minor changes and a reference adde

On non-uniform smeared black branes

We investigate charged dilatonic black $p$-branes smeared on a transverse circle. The system can be reduced to neutral vacuum black branes, and we perform static perturbations for the reduced system to construct non-uniform solutions. At each order a single master equation is derived, and the Gregory-Laflamme critical wavelength is determined. Based on the non-uniform solutions, we discuss thermodynamic properties of this system and argue that in a microcanonical ensemble the non-uniform smeared branes are entropically disfavored even near the extremality, if the spacetime dimension is $D \le 13 +p$, which is the critical dimension for the vacuum case. However, the critical dimension is not universal. In a canonical ensemble the vacuum non-uniform black branes are thermodynamically favorable at $D > 12+p$, whereas the non-uniform smeared branes are favorable at $D > 14+p$ near the extremality.Comment: 24 pages, 2 figures; v2: typos corrected, submitted to Class.Quant.Gra

New Phase Diagram for Black Holes and Strings on Cylinders

We introduce a novel type of phase diagram for black holes and black strings on cylinders. The phase diagram involves a new asymptotic quantity called the relative binding energy. We plot the uniform string and the non-uniform string solutions in this new phase diagram using data of Wiseman. Intersection rules for branches of solutions in the phase diagram are deduced from a new Smarr formula that we derive.Comment: 19 pages, 6 figures, v2: typos corrected, v3: refs. added, comment on bounds on the relative binding energy n added in end of section

Counting Yang-Mills Dyons with Index Theorems

We count the supersymmetric bound states of many distinct BPS monopoles in N=4 Yang-Mills theories and in pure N=2 Yang-Mills theories. The novelty here is that we work in generic Coulombic vacua where more than one adjoint Higgs fields are turned on. The number of purely magnetic bound states is again found to be consistent with the electromagnetic duality of the N=4 SU(n) theory, as expected. We also count dyons of generic electric charges, which correspond to 1/4 BPS dyons in N=4 theories and 1/2 BPS dyons in N=2 theories. Surprisingly, the degeneracy of dyons is typically much larger than would be accounted for by a single supermultiplet of appropriate angular momentum, implying many supermutiplets of the same charge and the same mass.Comment: 34 pages, 1 figure, LaTe

Predictive glycoengineering of biosimilars using a Markov chain glycosylation model

Biosimilar drugs must closely resemble the pharmacological attributes of innovator products to ensure safety and efficacy to obtain regulatory approval. Glycosylation is one critical quality attribute that must be matched, but it is inherently difficult to control due to the complexity of its biogenesis. This usually implies that costly and time-consuming experimentation is required for clone identification and optimization of biosimilar glycosylation. Here, we describe a computational method that utilizes a Markov model of glycosylation to predict optimal glycoengineering strategies to obtain a specific glycosylation profile with desired properties. The approach uses a genetic algorithm to find the required quantities to perturb glycosylation reaction rates that lead to the best possible match with a given glycosylation profile. Furthermore, the approach can be used to identify cell lines and clones that will require minimal intervention while achieving a glycoprofile that is most similar to the desired profile. Thus, this approach can facilitate biosimilar design by providing computational glycoengineering guidelines that can be generated with a minimal time and cost