Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

Supplemental Table 3-mouse LV DEGs.xlsx

Differentially expressed gene in the left ventricle of the mouse following 3 days AngII/PE infusion. This is the mouse model of HFpEF.</p

Supplemental Table 4 mouse-human comp.xlsx

Comparison between mouse LV Day 3 AngII/PE with human HFpEF</p

CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity