ポリプロピレン/ゴム系ブレンド射出成形品に発生するフローマークおよびストライプ状劣化と成形品の高次構造

取得学位：博士(工学），学位授与番号：博甲第994号，学位授与年月日：平成20年3月22

Scritter A multiplexed image system for a public screen

Abstract -Scritter is a system that enables one the superimposition of invisible messages and comments on a large screen while sharing a movie. By putting other information on an image that only users who wear special glasses (named "IP(Information Polarized)-Glasses") can see, a multiplex of image media can be realized. By selecting the glasses, visible images can be changed into a movie or a message

Zinc is a novel intracellular second messenger

Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcɛ receptor I [FcɛRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcɛRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger

FcɛRI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane

The aggregation of high affinity IgE receptors (Fcɛ receptor I [FcɛRI]) on mast cells is potent stimulus for the release of inflammatory and allergic mediators from cytoplasmic granules. However, the molecular mechanism of degranulation has not yet been established. It is still unclear how FcɛRI-mediated signal transduction ultimately regulates the reorganization of the cytoskeleton and how these events lead to degranulation. Here, we show that FcɛRI stimulation triggers the formation of microtubules in a manner independent of calcium. Drugs affecting microtubule dynamics effectively suppressed the FcɛRI-mediated translocation of granules to the plasma membrane and degranulation. Furthermore, the translocation of granules to the plasma membrane occurred in a calcium-independent manner, but the release of mediators and granule–plasma membrane fusion were completely dependent on calcium. Thus, the degranulation process can be dissected into two events: the calcium-independent microtubule-dependent translocation of granules to the plasma membrane and calcium-dependent membrane fusion and exocytosis. Finally, we show that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway

Uterine cervical adenosquamous carcinoma with micropapillary components

A 52-year-old Japanese woman was admitted to our hospital for uterine cervical cancer treatment. She had noticed irregular genital bleeding, and uterine cervical biopsy confirmed the presence of a squamous cell carcinoma (SqCC). Radical hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymph node dissection were performed, and pathology confirmed adenosquamous carcinoma (ASC) at stage pT1b1pN1cM0 and stage IIIB. Interestingly, the adenocarcinoma components, which were approximately 5% of the ASC, were purely invasive micropapillary carcinoma (IMC) or IMC-like nests. The IMC and IMC-like components were seen at the invasive front connected to the squamous component. The patient underwent cisplatin-based concurrent chemoradiotherapy and has been disease-free for 1 year following the surgery. IMC is a histopathological type of adenocarcinoma of various organs, and uterine cervical IMCs have recently attracted attention as aggressive tumors. However, uterine cervical IMCs are rare and are not an independent entity in the latest 2020 World Health Organization’s classification of uterine cervical cancers. This case report describes the clinicopathological features of a patient with rare uterine cervical ASC and the curative potential of human epidermal growth factor receptor 2-targeting therapy