The baby box : Enhancing the wellbeing of babies and mothers around the world

The baby box is a Finnish social innovation that has captivated interest around the globe. This book highlights the journey of the baby box in over 60 countries, offering a comprehensive overview of the Finnish baby box and its many international adaptations. The story of the baby box begins in post-war Finland, where it evolved from a community-based resource to a nationally-funded and internationally recognized social benefit. The global mapping of the baby box presented in this book expands on this history by exploring the influence of the baby box concept internationally, from refugee camps and high-income countries to remote islands and prisons. Written by an international, multi-disciplinary team of researchers, this book explores the baby box concept from various angles. The diverse and expansive nature of this study makes it an excellent resource for parents, researchers, and anyone generally interested in the baby box concept. Also showcased are the many creative solutions that baby box programme organisers have devised to address context-specific challenges, making it additionally useful as a handbook for policy-makers or professionals developing their own programme.The baby box is a social innovation: a maternity package with baby clothes and other items for expectant mothers to promote the wellbeing of baby and family. In Finland, the baby box (officially called the maternity package) has been a universal benefit since 1949 and is given to all expectant mothers provided they attend antenatal care (ANC). The baby box is still considered to be a valuable social benefit in Finland today, with 95% of first-time mothers choosing the box instead of a cash grant. Although it is known that the baby box concept has been adapted across the world, there is little information available about how these adaptations have been made and for what purpose the boxes are given out. In order to map these programmes, we conducted a research project on baby boxes globally. Based on our findings, this report introduces the baby box concept, its various adaptations, and its possible uses to improve maternal and child health and wellbeing globally. The contents of this report are based on a mapping of 91 baby box programmes and an in-depth study of 29 programmes across different world regions in high-, middle- and low-income countries. These programmes were initiated by governmental bodies, non-profit organisations, United Nations (UN) agencies, hospitals, and academic institutions. Although we use the term baby “box” throughout the report, many programmes used a different container, such as a basket or bag, to package the items. The programmes ranged in scale from small to nationwide and targeted various groups, from specific vulnerable communities to all pregnant women in a country. Programmes set various goals, including reducing infant or maternal mortality, promoting the wellbeing of babies and mothers, easing financial and parenting burden, encouraging the uptake of health and community support services, and strengthening communities and reducing inequalities. They intended to achieve their goals through the practical support provided by the box and items, as well as the conditions attached to claiming the box (e.g. attendance at services) and additional education (e.g. booklets or arranged groups) included in the programme. The impact of the baby box is of timely concern, as governments are increasingly interested in the concept. However, it is difficult to provide an unequivocal answer to the question of whether the baby box “works,” as this depends on the desired outcomes of the programme. In addition, due to resource constraints, few programmes measure the impact of their intervention systematically. In response to this question and these restraints, we outline the potential current contributions of the baby box to the wellbeing of mothers and babies and provide a commentary on its possible future impact. For example, there is emerging evidence globally that baby box programmes can increase the rates of attending ANC or giving birth at a health facility, which may save lives in contexts where these rates are traditionally low. Baby box programmes may also provide psychosocial support for the mother during the vulnerable time of childbirth. Beyond their potential to support families in their everyday lives, baby box programmes may also be valuable in contexts where families have been forced to flee their homes, such as natural disasters or refugee camps. In addition to our findings, we also discuss high-interest topics surrounding the baby box, including safety issues. Ultimately, we intend for our report to serve as an overview of baby box programmes and a foundation for further research, as well as a reference for those interested in the topic or aiming to implement or evaluate a baby box programme themselves. The baby box is not a one-size-fits-all solution to intricate health challenges. However, it offers significant health and social gains, especially for those who are commonly the most vulnerable in communities: mothers and babies.31,00 euroanonPeerReviewedVertaisarvioimato

A predictive model of overall survival in patients with metastatic castration-resistant prostate cancer

Metastatic castration resistant prostate cancer (mCRPC) is one of the most common cancers with a poor prognosis. To improve prognostic models of mCRPC, the Dialogue for Reverse Engineering Assessments and Methods (DREAM) Consortium organized a crowdsourced competition known as the Prostate Cancer DREAM Challenge. In the competition, data from four phase III clinical trials were utilized. A total of 1600 patients’ clinical information across three of the trials was used to generate prognostic models, whereas one of the datasets (313 patients) was held out for blinded validation. As a performance baseline, a model presented in a recent study (so called Halabi model) was used to assess improvements of the new models. This paper presents the model developed by the team TYTDreamChallenge to predict survival risk scores for mCRPC patients at 12, 18, 24 and 30-months after trial enrollment based on clinical features of each patient, as well as an improvement of the model developed after the challenge. The TYTDreamChallenge model performed similarly as the gold-standard Halabi model, whereas the post-challenge model showed markedly improved performance. Accordingly, a main observation in this challenge was that the definition of the clinical features used plays a major role and replacing our original larger set of features with a small subset for training increased the performance in terms of integrated area under the ROC curve from 0.748 to 0.779.</p

The Hard Life: A Pedagogical Experience in Industrial Design

Thispaperseekstoanalyzeanddiscussaredesignprojectdeveloped by students of master’s degree in industrial design. Based on the book The Hard Life, from English designer Jasper Morrison, the briefing proposed the devel- opment of concepts for new products inspired by the selection of objects in the book, and respective written interpretations. It seeks to explore the dialogue between the original objects – their use, Morrison’s interpretation - and the reinterpretation made by the students considering the current material culture. Accompanied and coordinated with Bisarro, contemporary studio dedicated to the artisan production of small series in Bisalhães black clay, UNESCO Immaterial Cultural Heritage, the project seeks to explore the boundaries and common ground between memory and contemporary times. More than the results, it is intended to discuss proposals and approaches, from functional interpretations, formal inspiration, to the appropriation of affordance and gesture.info:eu-repo/semantics/publishedVersio

Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [&lt;1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None

The qualitative transparency deliberations: insights and implications

In recent years, a variety of efforts have been made in political science to enable, encourage, or require scholars to be more open and explicit about the bases of their empirical claims and, in turn, make those claims more readily evaluable by others. While qualitative scholars have long taken an interest in making their research open, reflexive, and systematic, the recent push for overarching transparency norms and requirements has provoked serious concern within qualitative research communities and raised fundamental questions about the meaning, value, costs, and intellectual relevance of transparency for qualitative inquiry. In this Perspectives Reflection, we crystallize the central findings of a three-year deliberative process—the Qualitative Transparency Deliberations (QTD)—involving hundreds of political scientists in a broad discussion of these issues. Following an overview of the process and the key insights that emerged, we present summaries of the QTD Working Groups’ final reports. Drawing on a series of public, online conversations that unfolded at www.qualtd.net, the reports unpack transparency’s promise, practicalities, risks, and limitations in relation to different qualitative methodologies, forms of evidence, and research contexts. Taken as a whole, these reports—the full versions of which can be found in the Supplementary Materials—offer practical guidance to scholars designing and implementing qualitative research, and to editors, reviewers, and funders seeking to develop criteria of evaluation that are appropriate—as understood by relevant research communities—to the forms of inquiry being assessed. We dedicate this Reflection to the memory of our coauthor and QTD working group leader Kendra Koivu