Iron concretions in the Cretaceous Dakota Formation

The Cretaceous Dakota Formation contains abundant iron oxide concretions. The precursors to the iron concretions are siderite (FeCO3) nodules that formed in a reducing floodplain environment. A variety of concretion morphologies formed when the precursor siderite nodules were dissolved by oxidizing groundwater in a paleoaquifer. Iron-oxidizing bacteria are able to oxidize aqueous Fe(II) to Fe(III) oxy-hydroxide at microaerophilic and neutrophilic conditions. This study investigated these concretions to determine if there was a microbial element in their formation and to characterize the concretion morphologies present in the Dakota. This is important for complete paleoenvironment interpretations and astrobiology pursuits

Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures

<p>Abstract</p> <p>Background</p> <p>The rostral telencephalic dorsal midline is an organizing center critical for the formation of the future cortex and hippocampus. While the intersection of WNTs, BMPs, and FGFs establishes boundaries within this critical center, a direct role of Shh signaling in this region remains controversial. In this paper we show that both increased and decreased Shh signaling directly affects boundary formation within the telencephalic dorsal midline.</p> <p>Results</p> <p>Viral over-expression of Shh in the embryonic telencephalon prevents formation of the cortical hem and choroid plexus, while expanding the roof plate. In a transgenic model where cholesterol-lacking ShhN is expressed from one allele (<it>ShhN/+</it>), genes expressed in all three domains, cortical hem, choroid plexus and roof plate expand. In <it>Gli1/2 -/- </it>mutant brains, where Shh signaling is reduced, the roof plate expands, again at the expense of cortical hem and plexus. Cell autonomous activation of Shh signaling in the dorsal midline through Gdf7-driven activated Smoothened expression results in expansion of the <it>Wnt3a</it>-expressing cortical hem into the plexus domain. In addition, developmental stage determines dorsal midline responsiveness to Shh.</p> <p>Conclusions</p> <p>Together, these data demonstrate that balanced Shh signaling is critical for maintaining regional boundaries within the dorsal midline telencephalic organizing center.</p

Testing and Evaluation of MASH TL-3 Transition Between Guardrail and Portable Concrete Barriers

Three full-scale vehicle crash tests were conducted according to the Manual for Assessing Safety Hardware (MASH) Test Level 3 (TL-3) safety performance criteria on a transition between the Midwest Guardrail System (MGS) and a portable concrete barrier (PCB) system. The transition system utilized for test nos. MGSPCB-1 through MGSPCB-3 consisted of a standard MGS that overlapped a series of F- shape PCB segments that approached the MGS at a 15H:1V flare. In the overlapped portion of the barrier systems, uniquely-designed blockout holders and a specialized W-beam end shoe mounting bracket were used to connect the systems. In test no. MGSPCB-1, a 5,079-lb (2,304-kg) pickup truck impacted the barrier at 63.2 mph (101.8 km/h) and 25.3 degrees. The barrier captured and redirected the 2270P vehicle, and the vehicle decelerations were within the recommended occupant risk limits. In test no. MGSPCB-2, a 2,601-lb (1,180-kg) car impacted the barrier at 65.1 mph (104.8 km/h) and 24.0 degrees. The barrier captured and redirected the 1100C vehicle, and the vehicle decelerations were within the recommended occupant risk limits. In test no. MGSPCB-3, a 5,177-lb (2,348-kg) pickup truck impacted the barrier at 63.1 mph (101.5 km/h) and 24.6 degrees. For this test, the system was impacted in the reverse direction. The barrier captured and redirected the 2270P vehicle, and the vehicle decelerations were within the recommended occupant risk limits. Based on the results of these successful crash tests, it is believed that the transition design detailed herein represents the first MASH TL- 3 crashworthy transition between the MGS and PCBs

MASH Test Nos. 3-11 and 3-10 on a Non-Proprietary Cable Median Barrier

The Midwest States Pooled Fund has been developing a new non-proprietary cable median barrier. This system incorporates four evenly spaced cables, Midwest Weak Posts spaced at 8 to 16 ft (2.4 to 4.9 m) intervals, and a bolted, tabbed bracket to attach the cables to each post. Full-scale crash testing was needed to evaluate the barrier’s safety performance. According to the Manual for Assessing Safety Hardware (MASH) updated/proposed testing matrix for cable barriers installed within a 6H:1V or median ditch, a series of eight full-scale tests are required to evaluate the safety performance of a system. A ninth test is required to establish the working width for systems with variable post spacing. Three full-scale crash tests were performed. Test no. MWP-4 was conducted according to MASH test no. 3-11 and utilized a 2270P pickup truck impacting the barrier on level terrain. The vehicle was contained by the barrier, and the test was deemed acceptable. Test no. MWP-6 was conducted according to MASH test no. 3-10 and utilized a 1100C passenger car impacting the barrier on level terrain. The vehicle was contained and redirected by the system. However, the system posts penetrated the occupant compartment through tearing and rupture of the vehicle floor board, and the test was deemed unacceptable. Test no. MWP-7 was also conducted with a 1100C vehicle according to MASH test no. 3-10. Alterations were made to the system posts. Although the vehicle was contained by the system, occupant compartment penetration by line posts was again observed. Test no. MWP-7 was deemed unacceptable

MASH Test Nos. 3-11 and 3-10 on a Non-Proprietary Cable Median Barrier

The Midwest States Pooled Fund has been developing a new non-proprietary cable median barrier. This system incorporates four evenly spaced cables, Midwest Weak Posts spaced at 8 to 16 ft (2.4 to 4.9 m) intervals, and a bolted, tabbed bracket to attach the cables to each post. Full-scale crash testing was needed to evaluate the barrier’s safety performance. According to the Manual for Assessing Safety Hardware (MASH) updated/proposed testing matrix for cable barriers installed within a 6H:1V or median ditch, a series of eight full-scale tests are required to evaluate the safety performance of a system. A ninth test is required to establish the working width for systems with variable post spacing. Three full-scale crash tests were performed. Test no. MWP-4 was conducted according to MASH test no. 3-11 and utilized a 2270P pickup truck impacting the barrier on level terrain. The vehicle was contained by the barrier, and the test was deemed acceptable. Test no. MWP-6 was conducted according to MASH test no. 3-10 and utilized a 1100C passenger car impacting the barrier on level terrain. The vehicle was contained and redirected by the system. However, the system posts penetrated the occupant compartment through tearing and rupture of the vehicle floor board, and the test was deemed unacceptable. Test no. MWP-7 was also conducted with a 1100C vehicle according to MASH test no. 3-10. Alterations were made to the system posts. Although the vehicle was contained by the system, occupant compartment penetration by line posts was again observed. Test no. MWP-7 was deemed unacceptable

What You Don’t Know Can Hurt You: Communicating Health Law with Vermont Physicians

Background: Physicians today need a working knowledge of pertinent medical law. With an increased focus on patients’ rights in health care, states are encouraged to set specific laws protecting patients. The additional medical legislation places a challenge on physicians to continually update their medical-legal acumen such as disease reporting, malpractice issues, and medical information access.Little research has been conducted on physicians’ knowledge of the law and medicine. In an effort to expand upon these topics and to find an efficient way to make information about the law and medicine accessible to Vermont physicians, the University of Vermont College of Medicine partnered with the Vermont Board of Medical Practice to answer the following questions: • How well do Vermont physicians understand laws that relate to the practice of medicine? • How do Vermont physicians access nformation on law and medicine? • What topics are most relevant and important to Vermont physicians? • What educational methods willbe effective and how can the Vermont Board of Medial Practice best serve such education needs?https://scholarworks.uvm.edu/comphp_gallery/1018/thumbnail.jp